Patents by Inventor Hans-Heinrich Horl

Hans-Heinrich Horl has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11224843
    Abstract: The present invention relates to a crosslinked unreinforced cellulose hydrate membrane crosslinked using at least two different crosslinking agents, to a method for the production thereof and to the use of the crosslinked unreinforced cellulose hydrate membrane according to the invention.
    Type: Grant
    Filed: December 1, 2017
    Date of Patent: January 18, 2022
    Assignee: Sartorius Stedim Biotech GmbH
    Inventors: Sandra Van Der Kruijs, Annette Reiche, Gabriel Nino-Amézquita, Louis Villain, Hans-Heinrich Hörl, Dieter Melzner, Franziska Bäthe
  • Publication number: 20200230557
    Abstract: The present invention relates to a crosslinked unreinforced cellulose hydrate membrane crosslinked using at least two different crosslinking agents, to a method for the production thereof and to the use of the crosslinked unreinforced cellulose hydrate membrane according to the invention.
    Type: Application
    Filed: December 1, 2017
    Publication date: July 23, 2020
    Inventors: Sandra Van Der Kruijs, Annette Reiche, Gabriel Nino-Amézquita, Louis Villain, Hans-Heinrich Hörl, Dieter Melzner, Franziska Bäthe
  • Patent number: 10253299
    Abstract: The present invention relates to a sulfated cellulose hydrate membrane, a method for the preparation thereof and the use of the membrane as adsorption membrane for the purification of viruses.
    Type: Grant
    Filed: September 11, 2014
    Date of Patent: April 9, 2019
    Assignee: Sartorius Stedium Biotech GMBH
    Inventors: Louis Villain, Hans-Heinrich Hörl, Christian Brumm
  • Publication number: 20160257941
    Abstract: The present invention relates to a sulfated cellulose hydrate membrane, a method for the preparation thereof and the use of the membrane as adsorption membrane for the purification of viruses.
    Type: Application
    Filed: September 11, 2014
    Publication date: September 8, 2016
    Inventors: Louis Villain, Hans-Heinrich Hörl, Christian Brumm
  • Patent number: 9433904
    Abstract: There is provided a cellulose hydrate membrane having a porous double structure which consists of micropores having a diameter in the range from >100 nm to 20 ?m and ultrapores which have a diameter of <100 nm and which are not accessible to Blue Dextran having an average molecular weight Mw of 2 000 000, wherein the fraction of the volume of the ultrapores is more than 15% of the entire pore volume accessible to water. In addition, a method for producing the membrane, its use as an adsorption membrane, and an apparatus for membrane chromatography are specified.
    Type: Grant
    Filed: February 10, 2009
    Date of Patent: September 6, 2016
    Assignee: SARTORIUS STEDIM BIOTECH GMBH
    Inventors: Wolfgang Demmer, René Faber, Hans-Heinrich Hörl, Csilla Kiss, Dietmar Nuβbaumer
  • Patent number: 8343350
    Abstract: The invention comprises a membrane and device and method for removing proteases from fluids, particularly from biological fluids and pharmaceutical solutions, which uses a microporous membrane body, whereby inhibitors that selectively bind proteases are coupled to the membrane body by chemically activated groups.
    Type: Grant
    Filed: June 17, 2003
    Date of Patent: January 1, 2013
    Assignee: Sartorius AG
    Inventors: Wolfgang Demmer, Dietmar Nussbaumer, Hans-Heinrich Hörl
  • Patent number: 8343351
    Abstract: The invention comprises a membrane and device and method for removing proteases from fluids, particularly from biological fluids and pharmaceutical solutions, which uses a microporous membrane body, whereby inhibitors that selectively bind proteases are coupled to the membrane body by chemically activated groups.
    Type: Grant
    Filed: May 17, 2006
    Date of Patent: January 1, 2013
    Assignee: Sartorius AG
    Inventors: Wolfgang Demmer, Dietmar Nussbaumer, Hans-Heinrich Hörl
  • Publication number: 20110147292
    Abstract: There is provided a cellulose hydrate membrane having a porous double structure which consists of micropores having a diameter in the range from >100 nm to 20 ?m and ultrapores which have a diameter of <100 nm and which are not accessible to Blue Dextran having an average molecular weight Mw of 2 000 000, wherein the fraction of the volume of the ultrapores is more than 15% of the entire pore volume accessible to water. In addition, a method for producing the membrane, its use as an adsorption membrane, and an apparatus for membrane chromatography are specified.
    Type: Application
    Filed: February 10, 2009
    Publication date: June 23, 2011
    Applicant: SARTORIUS STEDIM BIOTECH GMBH
    Inventors: Wolfgang Demmer, René Faber, Hans-Heinrich Hörl, Csilla Kiss, Dietmar Nußbaumer
  • Patent number: 7422686
    Abstract: There is disclosed a process for the production of cellulose hydrate ultrafiltration membranes having improved filtration performance and the ultrafiltration membranes produced by the process.
    Type: Grant
    Filed: November 1, 2005
    Date of Patent: September 9, 2008
    Assignee: Sartorius Stedim Biotech GmbH
    Inventors: Dietmar Nussbaumer, Hans-Heinrich Hörl
  • Publication number: 20060216807
    Abstract: The invention comprises a membrane and device and method for removing proteases from fluids, particularly from biological fluids and pharmaceutical solutions, which uses a microporous membrane body, whereby inhibitors that selectively bind proteases are coupled to the membrane body by chemically activated groups.
    Type: Application
    Filed: May 17, 2006
    Publication date: September 28, 2006
    Inventors: Wolfgang Demmer, Dietmar Nussbaumer, Hans-Heinrich Horl
  • Publication number: 20060096912
    Abstract: There is disclosed a process for the production of cellulose hydrate ultrafiltration membranes having improved filtration performance and the ultrafiltration membranes produced by the process.
    Type: Application
    Filed: November 1, 2005
    Publication date: May 11, 2006
    Inventors: Dietmar Nussbaumer, Hans-Heinrich Horl
  • Publication number: 20050245431
    Abstract: The invention comprises a membrane and device and method for removing proteases from fluids, particularly from biological fluids and pharmaceutical solutions, which uses a microporous membrane body, whereby inhibitors that selectively bind proteases are coupled to the membrane body by chemically activated groups.
    Type: Application
    Filed: June 17, 2003
    Publication date: November 3, 2005
    Inventors: Wolfgang Demmer, Dietmar Nussbaumer, Hans-Heinrich Horl
  • Publication number: 20050208637
    Abstract: The invention describes a membrane and a method of making and using the same, the membrane being made from a microporous membrane body with an affinity ligand capable of interacting with at least one type of biomolecule found in a fluid, whereby the membrane body may be stored in a dried state yet retain the activity of the affinity ligand.
    Type: Application
    Filed: June 21, 2003
    Publication date: September 22, 2005
    Inventors: Wolfgang Demmer, Dietmar Nussbaumer, Hans-Heinrich Horl
  • Patent number: 6294090
    Abstract: An adsorptive separation device is disclosed having at least one spiral wound adsorption membrane situated around the periphery of a core mandrel wherein the flow is radial from a feed plenum situated between the core mandrel and the membrane, through the membrane to a permeate plenum located between the membrane and a housing for both the core mandrel and the spiral wound membrane. An array of such separation devices is also disclosed showing connections in parallel, in series, in both parallel and in series and in tandem.
    Type: Grant
    Filed: September 16, 1999
    Date of Patent: September 25, 2001
    Assignee: Sartorius AG
    Inventors: Dietmar Nussbaumer, Khoung To Vinh, Abdul Weiss, Wolfgang Demmer, Hans-Heinrich Hörl, Andreas Graus, Günter Pradel
  • Patent number: 6017454
    Abstract: A filtration unit for the separation of substances from liquids utilizes a rotatable cylindrical module with a permeable wall disposed within a housing. A filter element which has at least one band of microporous membrane adsorber having a specific adsorption affinity for the substances to be separated is disposed within the cylindrical module so that the membrane absorber is abutted to the cylindrical module. The filter element encircles the feed inlet and can be in the form of an endless loop. A permeate plenum lies between the cylindrical module and the housing. The cylindrical module includes a liquid impermeable end cap which is provided with a coupling member adapted for connection to a drive of variable rotational speed.
    Type: Grant
    Filed: April 14, 1997
    Date of Patent: January 25, 2000
    Assignee: Sartorius AG
    Inventors: Hans-Heinrich Horl, Wolfgang Demmer, Dietmar Nussbaumer
  • Patent number: 5739316
    Abstract: A process for cross-linking a cellulose hydrate membrane by use of a water-soluble diepoxide in an alkaline solution. The membrane so produced is highly resistant to attack by alkalis, acids and cellulases, and is readily regenerable by alkaline cleaning.
    Type: Grant
    Filed: May 16, 1996
    Date of Patent: April 14, 1998
    Assignee: Sartorius AG
    Inventors: Hans Beer, Wolfgang Demmer, Hans-Heinrich Horl, Dieter Melzner, Dietmar Nussbaumer, Hans-Weddo Schmidt, Eberhard Wunn
  • Patent number: 5618418
    Abstract: A dead-end filtration unit without a housing comprising at least one filter cassette, each cassette comprising a plurality of laminar sections of porous adsorptive membrane, which have been rendered fluid-impermeable on their peripheries, the cassettes being sealingly compressed between two filter retainers fitted with feed inlet and permeate outlet and wherein the laminar sections are made of the same or different membrane adsorber types.
    Type: Grant
    Filed: September 7, 1995
    Date of Patent: April 8, 1997
    Assignee: Sartorius AG
    Inventors: Wolfgang Demmer, Hans-Heinrich Horl, Dietmar Nussbaumer, Abdul R. Weiss
  • Patent number: 5556708
    Abstract: There is disclosed a method for grafting unsaturated monomers to nitrogen-containing polymers in an aqueous environment and in the presence of carbon tetrachloride and certain reducing agents.
    Type: Grant
    Filed: July 1, 1994
    Date of Patent: September 17, 1996
    Assignee: Sartorius AG
    Inventors: Hans-Heinrich Horl, Dietmar Nussbaumer, Eberhard Wunn
  • Patent number: 5547575
    Abstract: Fabrication of the surface-grafted microporous membranes by coating the membrane with an N-halogenated compound, followed by grafting with an unsaturated monomer and sodium dithionite in a primarily aqueous solution that may contain an organic halogen compound selected from carbon tetrachloride and trichloroacetic acid. The coating may be formed in situ and may be cross-linked.
    Type: Grant
    Filed: December 23, 1994
    Date of Patent: August 20, 1996
    Assignee: Sartorius AG
    Inventors: Wolfgang Demmer, Hans-Heinrich Horl, Dietmar Nussbaumer, Abdul R. Weiss, Eberhard Wunn
  • Patent number: 5215692
    Abstract: Halogen-substitutable hydrogen atoms are linked to nitrogen atoms of a polymer, with ethylenically-unsaturated monomers. By using inorganic or organic hypohalogenites and/or organic N-halogen derivatives as halogenation means, hydrogen atoms on the nitrogen atoms of the polymer membranes or polymer formed materials are replaced by halogen atoms and part of these are removed by reducing agents in the presence of ethylenically unsaturated monomers, with radical grafting of these on to the nitrogen atoms, after which the remaining halogen atoms are removed by reducing agents in the absence of monomers.
    Type: Grant
    Filed: May 1, 1992
    Date of Patent: June 1, 1993
    Assignee: Sartorius AG
    Inventors: Hans-Heinrich Horl, Dietmar Nussbaumer, Eberhard Wunn