Patents by Inventor Hans-Helmut Henschel

Hans-Helmut Henschel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparing the pure enantiomers of lifibrol and its alkyl esters
    Patent number: 5266721
    Abstract: The preparation of the pure enantiomers of LIFIBROL and its alkyl esters is achieved with surprisingly good yield by reacting the pure enantiomeric forms of S(-) R(+)-4-(4-tert.butylphenyl)-1,2-epoxy butane with 4-hydroxybenzoic acid alkyl ester at elevated temperature in DMF and in the presence of 4-hydroxybenzoic acid alkyl ester sodium salt. Thereafter, the raw reaction product is separated. Either the stereochemically pure LIFIBROL ester is then recovered by recrystallization or the precipitated LIFIBROL enantiomer is made in pure crystalline form by mild alkaline saponification and subsequent acidification.
    Type: Grant
    Filed: June 4, 1992
    Date of Patent: November 30, 1993
    Assignee: Klinge Pharma GmbH
    Inventors: Friedemann Reiter, Hans-Helmut Henschel
  • New p-oxibenzoic acid derivatives, process for their preparation and their use as drug
    Patent number: 5149865
    Abstract: The invention relates to p-oxibenzoic acid derivatives of the general formula (1) where: ##STR1## their diastereomers and enantiomers in pure form or as mixture of stereoisomeric forms and their physiologically compatible salts, a process for the preparation thereof and the use thereof for preparing drugs with hypolipemic effect.
    Type: Grant
    Filed: December 20, 1991
    Date of Patent: September 22, 1992
    Assignee: Klinge Pharma GmbH
    Inventors: Friedemann Reiter, Helmut Grill, Hans-Helmut Henschel, Michael Schliack, Klaus Seibel, Roland Loser, Gerhard Lang