Patents by Inventor Hans Holmegaard Soerensen

Hans Holmegaard Soerensen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Liquid Factor VIII Formulations
    Publication number: 20160000884
    Abstract: The invention is directed to a liquid, aqueous formulation of coagulation Factor VIII, comprising a Factor VIII molecule, a calcium salt in a concentration of more than 10 mM, and a saccharide and/or polyol in a concentration of at least 100 mM, wherein the formulation has a pH from 5.5-7.5. The invention furthermore provides a method for optimising a liquid formulation of coagulation Factor VIII, the method comprising the steps of: (i) Providing one or more liquid formulations comprising Factor VIII to be tested; (ii) Adding a protein denaturant to said liquid formulations, and incubating the resulting solutions for a predetermined period of time; (iii) Analysing the incubated solutions of (ii) for the presence of dissociated Factor VIII; and (iv) Selecting one or more formulation(s) having a desired low level of dissociated Factor VIII.
    Type: Application
    Filed: August 13, 2013
    Publication date: January 7, 2016
    Applicant: NOVO NORDISK A/S
    Inventors: Christian Rischel, Hans Holmegaard Soerensen, Michael Bech Jensen, Thomas Bjerg
  • Pharmaceutical formulation
    Patent number: 8841252
    Abstract: The invention relates to aqueous pharmaceutical formulations comprising human growth hormone, histidine, poloxamer, phenol, and mannitol.
    Type: Grant
    Filed: October 8, 2009
    Date of Patent: September 23, 2014
    Assignee: Novo Nordisk Health Care AG
    Inventors: Søren Bjørn, Hans Holmegaard Sørensen, Peter Langballe, Silke Møller Larsen, Kristen Ebbehøj, Birthe Lykkegaard Hansen
  • Pharmaceutical Formulation
    Publication number: 20100029569
    Abstract: The invention relates to aqueous pharmaceutical formulations comprising human growth hormone, histidine, poloxamer, phenol, and mannitol.
    Type: Application
    Filed: October 8, 2009
    Publication date: February 4, 2010
    Applicant: Novo Nordisk Healthcare AG
    Inventors: Søren Bjørn, Hans Holmegaard Sørensen, Peter Langballe, Silke Møller Larsen, Kirsten Ebbehøj, Birthe Lykkegaard Hansen
  • Freeze-dried preparation of human growth hormone
    Patent number: 6566329
    Abstract: A readily-soluble freeze-dried solid preparation of hGH with a minimal content of degradation products in terms of deamidation, dimers, polymers, and sulphoxide forms, obtainable by a method comprising a single lyophilization of an aqueous slurry of an amorphous hGH isoprecipitate, the slurry having a pH of from about 4.7 to 5.0 and being essentially free of buffer components other than acetate.
    Type: Grant
    Filed: June 14, 2000
    Date of Patent: May 20, 2003
    Assignee: Novo Nordisk A/S
    Inventors: Giorgio Meyn, Hans Holmegaard Sørensen, Thorkild Christensen