Patents by Inventor Hans Iding

Hans Iding has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Solid forms of 3-((1R,3R)-1-(2,6-difluoro-4-((1-(3-fluoropropyl)azetidin-3- yl)amino)phenyl)-3-methyl-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)-2,2-difluoropropan-1-ol and processes for preparing fused tricyclic compounds comprising a substituted phenyl or pyridinyl moiety, including methods of their use
    Patent number: 11780834
    Abstract: Provided herein are solid forms, salts, and formulations of 3-((1R,3R)-1-(2,6-difluoro-4-((1-(3-fluoropropyl)azetidin-3-yl)amino)phenyl)-3-methyl-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)-2,2-difluoropropan-1-ol, processes and synthesis thereof, and methods of their use in the treatment of cancer.
    Type: Grant
    Filed: December 3, 2020
    Date of Patent: October 10, 2023
    Assignees: Genentech, Inc., Hoffmann-La Roche Inc.
    Inventors: Cheol Keun Chung, Jie Xu, Hans Iding, Kyle Clagg, Michael Dalziel, Alec Fettes, Francis Gosselin, Ngiap-Kie Lim, Andrew McClory, Haiming Zhang, Paroma Chakravarty, Karthik Nagapudi, Sarah Robinson
  • Process for the Preparation of a Chiral Piperazine-2-carboxylic Acid
    Publication number: 20230175026
    Abstract: The invention relates to a novel process for the preparation of a chiral piperazine-2- carboxylic acid or of a salt thereof of the formula (I). The chiral piperazine-2-carboxylic acid derivatives of the formula (I) are key intermediates for the preparation of fused heteroaryl dihydro pyrimidines which are useful for the treatment and prophylaxis of hepatitis B virus infections.
    Type: Application
    Filed: April 26, 2021
    Publication date: June 8, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Joséphine Eliette Françoise CINQUALBRE, Stefan HILDBRAND, Paolo TOSATTI, Kurt PUENTENER, Dennis WETZL, Hans IDING, Patrick STOCKER, Nicolas Mickael FÉDOU, Paul SPURR
  • SOLID FORMS OF 3-((1R,3R)-1-(2,6-DIFLUORO-4-((1-(3-FLUOROPROPYL)AZETIDIN-3-YL)AMINO)PHENYL)-3-METHYL-1,3,4,9-TETRAHYDRO-2H-PYRIDO[3,4-B]INDOL-2-YL)-2,2-DIFLUOROPROPAN-1-OL AND PROCESSES FOR PREPARING FUSED TRICYCLIC COMPOUNDS COMPRISING A SUBSTITUTED PHENYL OR PYRIDINYL MOIETY, INCLUDING METHODS OF THEIR USE
    Publication number: 20220041587
    Abstract: Provided herein are solid forms, salts, and formulations of 3-((1R,3R)-1-(2,6-difluoro-4-((1-(3-fluoropropyl)azetidin-3-yl)amino)phenyl)-3-methyl-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)-2,2-difluoropropan-1-ol, processes and synthesis thereof, and methods of their use in the treatment of cancer.
    Type: Application
    Filed: December 3, 2020
    Publication date: February 10, 2022
    Applicants: Hoffmann-La Roche Inc., GENENTECH, INC.
    Inventors: CHEOL KEUN CHUNG, JIE XU, HANS IDING, KYLE CLAGG, MICHAEL DALZIEL, ALEC FETTES, FRANCIS GOSSELIN, NGIAP-KIE LIM, ANDREW MCCLORY, HAIMING ZHANG, PAROMA CHAKRAVARTY, KARTHIK NAGAPUDI, SARAH ROBINSON
  • Process for the manufacturing of medicaments
    Patent number: 11098028
    Abstract: The present invention provides a process for the manufacture of a compound of formula VIIIa and salts forms of VIIIa where Rc is an aryl sulfonic acid
    Type: Grant
    Filed: August 8, 2019
    Date of Patent: August 24, 2021
    Assignee: Genentech, Inc.
    Inventors: Jinguang Lin, Alexandra Chestakova, Wei Gu, Hans Iding, Jing Li, Xin Linghu, Patrik Meier, Chunbo Sha, Jeffrey Stults, Youchu Wang, Haiming Zhang, Jianqian Zhang, Tao Zhang
  • Process for the manufacturing of medicaments
    Patent number: 11066389
    Abstract: The present invention provides a process for the manufacture of a compound of formula VIIIa and salts forms of VIIIa where Rc is an aryl sulfonic acid
    Type: Grant
    Filed: December 18, 2019
    Date of Patent: July 20, 2021
    Assignee: Genentech, Inc.
    Inventors: Jinguang Lin, Alexandra Chestakova, Wei Gu, Hans Iding, Jing Li, Xin Linghu, Patrik Meier, Chunbo Sha, Jeffrey Stults, Youchu Wang, Haiming Zhang, Jianqian Zhang, Tao Zhang
  • Proline hydroxylases as well as uses, methods and products involving the same
    Patent number: 10968469
    Abstract: The present invention relates to the use of a protein as a hydroxylase, a host cell comprising the protein, the use of the protein or host cell in the production of hydroxy-pipecolic acid (HPA), a method of production HPA, methods of producing the protein, a mutant protein and a nucleic acid encoding the mutant protein and a vector comprising a nucleic acid encoding the protein.
    Type: Grant
    Filed: November 21, 2018
    Date of Patent: April 6, 2021
    Assignee: F. Hoffmann-La Roche, Inc.
    Inventors: Mara Boenitz-Dulat, Hans Iding, Dennis Wetzl, Alessa Hinzmann
  • Solid forms of 3-((1R,3R)-1-(2,6-difluoro-4-((1-(3- fluoropropyl)azetidin-3-yl)amino)phenyl)-3-methyl-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)-2,2-difluoropropan-1-ol and processes for preparing fused tricyclic compounds comprising a substituted phenyl or pyridinyl moiety, including methods of their use
    Patent number: 10954234
    Abstract: Provided herein are solid forms, salts, and formulations of 3-((1R,3R)-1-(2,6-difluoro-4-((1-(3-fluoropropyl)azetidin-3-yl)amino)phenyl)-3-methyl-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)-2,2-difluoropropan-1-ol, processes and synthesis thereof, and methods of their use in the treatment of cancer.
    Type: Grant
    Filed: June 17, 2019
    Date of Patent: March 23, 2021
    Assignees: Genentech, Inc., Hoffmann-La Roche, Inc.
    Inventors: Cheol Keun Chung, Jie Xu, Hans Iding, Kyle Clagg, Michael Dalziel, Alec Fettes, Francis Gosselin, Ngiap-Kie Lim, Andrew McClory, Haiming Zhang, Paroma Chakravarty, Karthik Nagapudi, Sarah Robinson
  • Process for preparing (cyclopentyl[d]pyrimidin-4-yl)piperazine compounds
    Patent number: 10870626
    Abstract: The present disclosure relates to processes for preparing (cyclopentyl[d]pyrimidin-4-yl)piperazine compounds, and more particularly relates to processes for preparing (R)-4-(5-methyl-7-oxo-6,7-dihydro-5H-cyclopenta[d] pyrimidin-4-yl)piperazine and N-protected derivatives thereof, which may be used as an intermediate in the synthesis of Ipatasertib (i.e., (S)-2-(4-chlorophenyl)-1-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-(isopropylamino)-propan-1-one). The present disclosure additionally relates to various compounds that are intermediates employed in these processes.
    Type: Grant
    Filed: September 18, 2019
    Date of Patent: December 22, 2020
    Assignees: F. Hoffman-La Roche AG, Genentech, Inc.
    Inventors: Francis Gosselin, Chong Han, Hans Iding, Reinhard Reents, Scott Savage, Beat Wirz
  • Processes for the preparation of pyrimidinylcyclopentane compounds
    Patent number: 10858324
    Abstract: The present invention relates to a process for the preparation of a compound of formula (I) wherein R1 is as defined herein, which is useful as an intermediate in the preparation of active pharmaceutical compounds.
    Type: Grant
    Filed: August 29, 2019
    Date of Patent: December 8, 2020
    Assignee: GENENTECH, INC.
    Inventors: Hans Iding, Reinhard Reents, Michelangelo Scalone, Francis Gosselin
  • PROCESS FOR THE MANUFACTURING OF MEDICAMENTS
    Publication number: 20200190061
    Abstract: The present invention provides a process for the manufacture of a compound of formula VIIIa and salts forms of VIIIa where Rc is an aryl sulfonic acid
    Type: Application
    Filed: December 18, 2019
    Publication date: June 18, 2020
    Applicant: Genentech, Inc.
    Inventors: JINGUANG LIN, ALEXANDRA CHESTAKOVA, WEI GU, HANS IDING, JING LI, XIN LINGHU, PATRIK MEIER, CHUNBO SHA, JEFFREY STULTS, YOUCHU WANG, HAIMING ZHANG, JIANQIAN ZHANG, TAO ZHANG
  • Process for the manufacturing of medicaments
    Patent number: 10611753
    Abstract: The present invention provides a process for the manufacture of a compound of formula VIIIa and salts forms of VIIIa where Rc is an aryl sulfonic acid
    Type: Grant
    Filed: January 10, 2018
    Date of Patent: April 7, 2020
    Assignee: Genentech, Inc.
    Inventors: Jinguang Lin, Alexandra Chestakova, Wei Gu, Hans Iding, Jing Li, Xin Linghu, Patrik Meier, Chunbo Sha, Jeffrey Stults, Youchu Wang, Haiming Zhang, Jianqian Zhang, Tao Zhang
  • PROCESSES FOR THE PREPARATION OF PYRIMIDINYLCYCLOPENTANE COMPOUNDS
    Publication number: 20200062717
    Abstract: The present invention relates to a process for the preparation of a compound of formula (I) wherein R1 is as defined herein, which is useful as an intermediate in the preparation of active pharmaceutical compounds.
    Type: Application
    Filed: August 29, 2019
    Publication date: February 27, 2020
    Applicant: GENENTECH, INC.
    Inventors: Hans Iding, Reinhard Reents, Michelangelo Scalone, Francis Gosselin
  • PROCESS FOR PREPARING (CYCLOPENTYL[d]PYRIMIDIN-4-YL)PIPERAZINE COMPOUNDS
    Publication number: 20200010428
    Abstract: The present disclosure relates to processes for preparing (cyclopentyl[d]pyrimidin-4-yl)piperazine compounds, and more particularly relates to processes for preparing (R)-4-(5-methyl-7-oxo-6,7-dihydro-5H-cyclopenta[d] pyrimidin-4-yl)piperazine and N-protected derivatives thereof, which may be used as an intermediate in the synthesis of Ipatasertib (i.e., (S)-2-(4-chlorophenyl)-1-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-(isopropylamino)-propan-1-one). The present disclosure additionally relates to various compounds that are intermediates employed in these processes.
    Type: Application
    Filed: September 18, 2019
    Publication date: January 9, 2020
    Inventors: Francis Gosselin, Chong Han, Hans Iding, Reinhard Reents, Scott Savage, Beat Wirz
  • SOLID FORMS OF 3-((1R,3R)-1-(2,6-DIFLUORO-4-((1-(3-FLUOROPROPYL)AZETIDIN-3-YL)AMINO)PHENYL)-3-METHYL-1,3,4,9-TETRAHYDRO-2H-PYRIDO[3,4-B]INDOL-2-YL)-2,2-DIFLUOROPROPAN-1-OL AND PROCESSES FOR PREPARING FUSED TRICYCLIC COMPOUNDS COMPRISING A SUBSTITUTED PHENYL OR PYRIDINYL MOIETY, INCLUDING METHODS OF THEIR USE
    Publication number: 20200002331
    Abstract: Provided herein are solid forms, salts, and formulations of 3-((1R,3R)-1-(2,6-difluoro-4-((1-(3-fluoropropyl)azetidin-3-yl)amino)phenyl)-3-methyl-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)-2,2-difluoropropan-1-ol, processes and synthesis thereof, and methods of their use in the treatment of cancer.
    Type: Application
    Filed: June 17, 2019
    Publication date: January 2, 2020
    Applicant: Genentech, Inc.
    Inventors: CHEOL KEUN CHUNG, JIE XU, HANS IDING, KYLE CLAGG, MICHAEL DALZIEL, ALEC FETTES, FRANCIS GOSSELIN, NGIAP-KIE LIM, ANDREW MCCLORY, HAIMING ZHANG, PAROMA CHAKRAVARTY, KARTHIK NAGAPUDI, SARAH ROBINSON
  • PROCESS FOR THE MANUFACTURING OF MEDICAMENTS
    Publication number: 20190367484
    Abstract: The present invention provides a process for the manufacture of a compound of formula VIIIa and salts forms of VIIIa where Rc is an aryl sulfonic acid
    Type: Application
    Filed: August 8, 2019
    Publication date: December 5, 2019
    Applicant: Genentech, Inc.
    Inventors: JINGUANG LIN, ALEXANDRA CHESTAKOVA, WEI GU, HANS IDING, JING LI, XIN LINGHU, PATRIK MEIER, CHUNBO SHA, JEFFREY STULTS, YOUCHU WANG, HAIMING ZHANG, JIANQIAN ZHANG, TAO ZHANG
  • Process for preparing (cyclopentyl[d]pyrimidin-4-yl)piperazine compounds
    Patent number: 10457648
    Abstract: The present disclosure relates to processes for preparing (cyclopentyl[d]pyrimidin-4-yl)piperazine compounds, and more particularly relates to processes for preparing (R)-4-(5-methyl-7-oxo-6,7-dihydro-5H-cyclopenta[d] pyrimidin-4-yl)piperazine and N-protected derivatives thereof, which may be used as an intermediate in the synthesis of Ipatasertib (i.e., (S)-2-(4-chlorophenyl)-1-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-(isopropylamino)-propan-1-one). The present disclosure additionally relates to various compounds that are intermediates employed in these processes.
    Type: Grant
    Filed: September 25, 2015
    Date of Patent: October 29, 2019
    Assignees: GENENTECH INC., F. HOFFMANN-LA ROCHE AG
    Inventors: Francis Gosselin, Chong Han, Hans Iding, Reinhard Reents, Scott Savage, Beat Wirz
  • Processes for the preparation of pyrimidinylcyclopentane compounds
    Patent number: 10435378
    Abstract: The present invention relates to a process for the preparation of a compound of formula (I) wherein R1 is as defined herein, which is useful as an intermediate in the preparation of active pharmaceutical compounds.
    Type: Grant
    Filed: November 30, 2017
    Date of Patent: October 8, 2019
    Assignee: GENENTECH, INC.
    Inventors: Hans Iding, Reinhard Reents, Michelangelo Scalone, Francis Gosselin
  • Process for the preparation of chiral 2-aryl morpholines
    Patent number: 10337039
    Abstract: The invention relates to a novel process for the preparation of chiral 2-(4-aminophenyl) morpholines of the formula wherein R1 is hydrogen an amino protecting group. The chiral 2-(4-aminophenyl) morpholines of the formula I are key intermediates for the preparation of compounds that have a good affinity to the trace amine associated receptors (TAARs).
    Type: Grant
    Filed: June 7, 2016
    Date of Patent: July 2, 2019
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Rene Trussardi, Hans Iding
  • PROLINE HYDROXYLASES AS WELL AS USES, METHODS AND PRODUCTS INVOLVING THE SAME
    Publication number: 20190153491
    Abstract: The present invention relates to the use of a protein as a hydroxylase, a host cell comprising the protein, the use of the protein or host cell in the production of hydroxy-pipecolic acid (HPA), a method of production HPA, methods of producing the protein, a mutant protein and a nucleic acid encoding the mutant protein and a vector comprising a nucleic acid encoding the protein.
    Type: Application
    Filed: November 21, 2018
    Publication date: May 23, 2019
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Mara Boenitz-Dulat, Hans Iding, Dennis Wetzl, Alessa Hinzmann
  • Mutant transaminases as well as methods and uses relating thereto
    Patent number: 10017749
    Abstract: The present invention relates to a mutant transaminase with increased transaminase activity relative to the wild-type transaminase, a fusion protein comprising the transaminase, a polynucleotide coding for the transaminase, a host cell comprising the polynucleotide, mutant transaminase and/or fusion protein, a method of producing an amine with the mutant transaminase or fusion protein and the use of the mutant transaminase or fusion protein for the production of an amine.
    Type: Grant
    Filed: April 15, 2016
    Date of Patent: July 10, 2018
    Assignee: HOFFMAN-LA ROCHE INC.
    Inventors: Steven Paul Hanlon, Hans Iding, Paul Spurr, Beat Wirz, Uwe Bornscheuer, Ioannis Pavlidis, Martin Steffen Weiss