Patents by Inventor Hans J. Fehling

Hans J. Fehling has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Vector for targeting the human Rosa26 gene
    Patent number: 11078494
    Abstract: The invention provides a method for generating a transgenic eukaryotic cell population having a modified human Rosa26 locus, which method includes introducing a functional DNA sequence into the human Rosa26 locus of starting eukaryotic cells. Also provided are targeting vectors useful in the method, as well as a cell population and a transgenic non-human animal comprising a modified human Rosa26 locus. Finally, the invention provides an isolated DNA sequence corresponding to the human Rosa26 locus.
    Type: Grant
    Filed: October 25, 2019
    Date of Patent: August 3, 2021
    Assignee: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
    Inventors: Gordon Keller, Stefan Irion, Herve Luche, Paul Gadue, Hans J. Fehling
  • STEM CELL GENE TARGETING
    Publication number: 20200071719
    Abstract: The invention provides a method for generating a transgenic eukaryotic cell population having a modified human Rosa26 locus, which method includes introducing a functional DNA sequence into the human Rosa26 locus of starting eukaryotic cells. Also provided are targeting vectors useful in the method, as well as a cell population and a transgenic non-human animal comprising a modified human Rosa26 locus. Finally, the invention provides an isolated DNA sequence corresponding to the human Rosa26 locus.
    Type: Application
    Filed: October 25, 2019
    Publication date: March 5, 2020
    Inventors: Gordon Keller, Stefan Irion, Herve Luche, Paul Gadue, Hans J. Fehling
  • Method of generating human pancreatic cells
    Patent number: 10392600
    Abstract: The present invention provides cell populations that are enriched for mesendoderm and mesoderm, and cell populations that are enriched for endoderm. In accordance with the present invention, a selectable marker gene has been recombinantly targeted to the brachyury locus to allow the isolation and characterization of cell populations that comprise brachyury positive mesendoderm and mesoderm cells. The cell populations of the invention are useful for generating cells for cell replacement therapy.
    Type: Grant
    Filed: August 15, 2016
    Date of Patent: August 27, 2019
    Assignee: ICAHN School of Medicine at Mount Sinai
    Inventors: Gordon Keller, Valerie Kouskoff, Atsushi Kubo, Hans J. Fehling
  • STEM CELL GENE TARGETING
    Publication number: 20170298384
    Abstract: The invention provides a method for generating a transgenic eukaryotic cell population having a modified human Rosa26 locus, which method includes introducing a functional DNA sequence into the human Rosa26 locus of starting eukaryotic cells. Also provided are targeting vectors useful in the method, as well as a cell population and a transgenic non-human animal comprising a modified human Rosa26 locus. Finally, the invention provides an isolated DNA sequence corresponding to the human Rosa26 locus.
    Type: Application
    Filed: October 21, 2016
    Publication date: October 19, 2017
    Inventors: Gordon M. Keller, Stefan Irion, Herve Luche, Paul Gadue, Hans J. Fehling
  • MESENDODERM AND MESODERM CELL POPULATIONS
    Publication number: 20160348069
    Abstract: The present invention provides cell populations that are enriched for mesendoderm and mesoderm, and cell populations that are enriched for endoderm. In accordance with the present invention, a selectable marker gene has been recombinantly targeted to the brachyury locus to allow the isolation and characterization of cell populations that comprise brachyury positive mesendoderm and mesoderm cells. The cell populations of the invention are useful for generating cells for cell replacement therapy.
    Type: Application
    Filed: August 15, 2016
    Publication date: December 1, 2016
    Inventors: Gordon Keller, Valerie Kouskoff, Atsushi Kubo, Hans J. Fehling
  • Stem cell gene targeting
    Patent number: 9481896
    Abstract: The invention provides a method for generating a transgenic eukaryotic cell population having a modified human Rosa26 locus, which method includes introducing a functional DNA sequence into the human Rosa26 locus of starting eukaryotic cells. Also provided are targeting vectors useful in the method, as well as a cell population and a transgenic non-human animal comprising a modified human Rosa26 locus. Finally, the invention provides an isolated DNA sequence corresponding to the human Rosa26 locus.
    Type: Grant
    Filed: May 20, 2015
    Date of Patent: November 1, 2016
    Assignee: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
    Inventors: Gordon Keller, Stefan Irion, Herve Luche, Paul Gadue, Hans J. Fehling
  • STEM CELL GENE TARGETING
    Publication number: 20160017371
    Abstract: The invention provides a method for generating a transgenic eukaryotic cell population having a modified human Rosa26 locus, which method includes introducing a functional DNA sequence into the human Rosa26 locus of starting eukaryotic cells. Also provided are targeting vectors useful in the method, as well as a cell population and a transgenic non-human animal comprising a modified human Rosa26 locus. Finally, the invention provides an isolated DNA sequence corresponding to the human Rosa26 locus.
    Type: Application
    Filed: May 20, 2015
    Publication date: January 21, 2016
    Inventors: Gordon Keller, Stefan Irion, Herve Luche, Paul Gadue, Hans J. Fehling
  • MESENDODERM AND MESODERM CELL POPULATIONS
    Publication number: 20150291931
    Abstract: The present invention provides cell populations that are enriched for mesendoderm and mesoderm, and cell populations that are enriched for endoderm. In accordance with the present invention, a selectable marker gene has been recombinantly targeted to the brachyury locus to allow the isolation and characterization of cell populations that comprise brachyury positive mesendoderm and mesoderm cells. The cell populations of the invention are useful for generating cells for cell replacement therapy.
    Type: Application
    Filed: June 26, 2015
    Publication date: October 15, 2015
    Inventors: Gordon Keller, Valerie Kouskoff, Atsushi Kubo, Hans J. Fehling
  • MESODERM AND DEFINITIVE ENDODERM CELL POPULATIONS
    Publication number: 20150218512
    Abstract: The present invention provides cell populations that are enriched for mesendoderm and mesoderm, and cell populations that are enriched for endoderm. The cell populations of the invention are useful for generating cells for cell replacement therapy.
    Type: Application
    Filed: February 26, 2015
    Publication date: August 6, 2015
    Inventors: Gordon M. Keller, Valerie Kouskoff, Atsushi Kubo, Hans J. Fehling
  • MESENDODERM AND MESODERM CELL POPULATIONS
    Publication number: 20140287494
    Abstract: The present invention provides cell populations that are enriched for mesendoderm and mesoderm, and cell populations that are enriched for endoderm. The cell populations of the invention are useful for generating cells for cell replacement therapy.
    Type: Application
    Filed: December 17, 2013
    Publication date: September 25, 2014
    Applicant: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
    Inventors: Gordon M. Keller, Valerie Kouskoff, Atsushi Kubo, Hans J. Fehling