Abstract: A cartridge for an aerosol delivery system. The cartridge includes a fluid reservoir including a first reservoir portion, a second reservoir portion, and at least one liquid barrier configured to separate the first and second reservoir portions. The first and second reservoir portions have respective first and second openings at a first end of the cartridge. The cartridge further includes a perforate membrane located at the first end of the cartridge and over the first and second openings. The first and second openings are configured to supply first and second liquids to a first side of the perforate membrane during use and the perforate membrane comprises a plurality of apertures configured to eject one or both of the first and second liquids from a second side of the perforate membrane in the form of liquid droplets when the perforate membrane is vibrated. An aerosol delivery system includes the cartridge.

Abstract: An aerosol delivery system includes a perforate membrane comprising a plurality of apertures, as well as a fluid reservoir reservoir in fluid communication with a first side of the perforate membrane and actuation means configured to vibrate the perforate membrane to cause a liquid in the fluid reservoir during use to be ejected as liquid droplets from a second side of the perforate membrane. The plurality of apertures comprises first and second arrays of apertures of first and second configurations which are grouped together in first and second discrete regions of the perforate membrane. The fluid reservoir includes first and second reservoir portions and a liquid barrier by which the first and second reservoir portions are separated. A removable cartridge for an aerosol delivery system.

Abstract: There is disclosed a liquid formulation for inhalation into the lungs, comprising an aqueous solution of nicotine or a nicotine analogous molecule, at least one organic and/or inorganic salt, an organic liquid having a viscosity higher than water, and optionally an organic alcohol, wherein the pH of the formulation is greater than pH 7 and the formulation does not include a propellant. There is further disclosed a corresponding method of aerosolising the liquid formulation, a method for delivering nicotine to the user, and an aerosol-generating device.

Abstract: Successive palletized stacks of blanks in a layer of such stacks on a penetrable support of cardboard or the like are lifted off the support by a substantially horizontal plate- or blade-like implement which is caused to penetrate between the upper side of the support and the underside of a selected stack prior to lifting of the selected stack off the support for transfer onto a conveyor or into a blank converting machine, such as a cigarette packing machine. An optical or other suitable monitoring unit has one or more sensors carried by the implement such that they share the movements of the implement to detect, and to effect the generation of defect signals in response to the detection of, improper operation of the apparatus, such as the penetration of the implement through and subsequent lifting of a portion of the support with a selected stack.

Abstract: Polypeptides comprising a collectin neck region, or variant or derivative thereof or amino acid sequence having the same or a similar amino acid pattern and/or hydrophobicity profile, are able to trimerize. Such polypeptides may comprise additional amino acids which may include heterologous amino acids, for example, forming a protein domain or derived from an immunoglobulin or comprising an amino acid which may be derivatized for attachment of a non-peptide moiety such as oligosaccharide, and may form homotrimers or heterotrimers. Heterotrimerization may be promoted by gentle heating, e.g. to about 50° C., then cooling to room temperature. One use for the polypeptides is in seeding collagen formation. Nucleic acid encoding the polypeptides and methods of their production are provided.