Patents by Inventor Hans-Jürgen Mair

Hans-Jürgen Mair has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND USES THEREOF
    Publication number: 20190241557
    Abstract: Provided are solid dispersions, solid molecular complexes, salts and crystalline polymorphs involving propane-1-sulfonic acid {3-[5-(4-chloro-phenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide.
    Type: Application
    Filed: September 6, 2018
    Publication date: August 8, 2019
    Inventors: Dipen Desai, Ralph Diodone, Zenaida Go, Prabha N. Ibrahim, Raman Iyer, Hans-Juergen Mair, Harpreet K. Sandhu, Navnit H. Shah, Gary Visor, Nicole Wyttenbach, Stephan Lauper, Johannes Pudewell, Frank Wierschem
  • COMPOSITIONS AND USES THEREOF
    Publication number: 20180111930
    Abstract: Provided are solid dispersions, solid molecular complexes, salts and crystalline polymorphs involving propane-1-sulfonic acid {3-[5-(4-chloro-phenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide.
    Type: Application
    Filed: May 26, 2017
    Publication date: April 26, 2018
    Inventors: Dipen Desai, Ralph Diodone, Zenaida Go, Prabha N. Ibrahim, Raman Iyer, Hans-Juergen Mair, Harpreet K. Sandhu, Navnit H. Shah, Gary Visor, Nicole Wyttenbach, Stephen Lauper, Johannes Pudewell, Frank Wierschem
  • Compositions and uses thereof
    Patent number: 9663517
    Abstract: Provided are solid dispersions, solid molecular complexes, salts and crystalline polymorphs involving propane-1-sulfonic acid {3-[5-(4-chloro-phenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide.
    Type: Grant
    Filed: August 19, 2016
    Date of Patent: May 30, 2017
    Assignees: Plexxikon Inc., Hoffman-La Roche Inc.
    Inventors: Dipen Desai, Ralph Diodone, Zenaida Go, Prabha N. Ibrahim, Raman Iyer, Hans-Juergen Mair, Harpreet K. Sandhu, Navnit H. Shah, Gary Visor, Nicole Wyttenbach, Stephan Lauper, Johannes Pudewell, Frank Wierschem
  • Process
    Patent number: 9603816
    Abstract: The present invention relates to a process for the preparation of S-[2-[1-(2 -ethylbutyl)cyclohexylcarbonylamino]-phenyl] 2-methylthiopropionate which is useful as a pharmaceutically active compound.
    Type: Grant
    Filed: December 18, 2013
    Date of Patent: March 28, 2017
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Hans-Juergen Mair, Reinhard Reents, Michelangelo Scalone, Shaoning Wang, Andreas Zogg
  • COMPOSITIONS AND USES THEREOF
    Publication number: 20160355513
    Abstract: Provided are solid dispersions, solid molecular complexes, salts and crystalline polymorphs involving propane-1-sulfonic acid {3-[5-(4-chloro-phenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide.
    Type: Application
    Filed: August 19, 2016
    Publication date: December 8, 2016
    Inventors: Dipen Desai, Ralph Diodone, Zenaida Go, Prabha N. Ibrahim, Raman Iyer, Hans-Juergen Mair, Harpreet K. Sandhu, Navnit H. Shah, Gary Visor, Nicole Wyttenbach, Stephan Lauper, Johannes Pudewell, Frank Wierschem
  • Compositions and uses thereof
    Patent number: 9447089
    Abstract: Provided are solid dispersions, solid molecular complexes, salts and crystalline polymorphs involving propane-1-sulfonic acid {3-[5-(4-chloro-phenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide.
    Type: Grant
    Filed: March 31, 2010
    Date of Patent: September 20, 2016
    Assignees: Plexxikon Inc., Hoffman-La Roche Inc.
    Inventors: Dipen Desai, Ralph Diodone, Zenaida Go, Prabha N. Ibrahim, Raman Iyer, Hans-Juergen Mair, Harpreet K. Sandhu, Navnit H. Shah, Gary Visor, Nicole Wyttenbach, Stephan Lauper, Johannes Pudewell, Frank Wierschem
  • Synthesis of Cyclosporin Analogs
    Publication number: 20140288266
    Abstract: The invention is directed to isomeric mixtures of cyclosporine analogues that are structurally similar to cyclosporine A. The mixtures possess enhanced efficacy and reduced toxicity over the individual isomers and over naturally occurring and other presently known cyclosporines and cyclosporine derivatives. Embodiments of the present invention are directed toward cis and trans-isomers of cyclosporin A analogs referred to as ISATX247, and derivatives thereof. ISATX247 isomers and alkylated, arylated, and deuterated derivatives are synthesized by stereoselective pathways where the particular conditions of a reaction determine the degree of stereoselectivity. Stereoselective pathways may utilize a Wittig reaction, or an organometallic reagent comprising inorganic elements such as boron, silicon, titanium, and lithium. The ratio of isomers in a mixture may range from about 10 to 90 percent by weight of the (E)-isomer to about 90 to 10 percent by weight of the (Z)-isomer, based on the total weight of the mixture.
    Type: Application
    Filed: March 18, 2014
    Publication date: September 25, 2014
    Applicant: Aurinia Pharmaceuticals, Inc.
    Inventors: Selvaraj A. Naicker, Randall W. Yatscoff, Robert T. Foster, Mark Abel, Seetharaman Jayaraman, Hans-Jürgen Mair, Jean-Michel Adam, Bruno Lohri
  • New Process
    Publication number: 20140171502
    Abstract: The present invention relates to a process for the preparation of S-[2-[1-(2-ethylbutyl)cyclohexylcarbonylamino]-phenyl] 2-methylthiopropionate which is useful as a pharmaceutically active compound.
    Type: Application
    Filed: December 18, 2013
    Publication date: June 19, 2014
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Hans-Juergen Mair, Reinhard Reents, Michelangelo Scalone, Shaoning Wang, Andreas Zogg
  • Process for the manufacture of pharmaceutically active compounds
    Patent number: 8741920
    Abstract: The present invention relates to a composition comprising the compound of formula (1), and the compound of formula (B),
    Type: Grant
    Filed: September 13, 2012
    Date of Patent: June 3, 2014
    Assignee: Hoffmann-La Roche, Inc.
    Inventors: Stefan Hildbrand, Hans-Juergen Mair, Roumen Nikolaev Radinov, Yi Ren, James Anderson Wright
  • Process
    Patent number: 8664403
    Abstract: The present invention relates to a process for the preparation of S-[2-[1-(2-ethylbutyl)cyclohexylcarbonylamino]-phenyl]2-methylthiopropionate which is useful as a pharmaceutically active compound.
    Type: Grant
    Filed: December 13, 2011
    Date of Patent: March 4, 2014
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Hans-Juergen Mair, Reinhard Reents, Michelangelo Scalone, Shaoning Wang, Andreas Zogg
  • Process for the manufacture of pharmaceutically active compounds
    Patent number: 8530661
    Abstract: The present invention further relates to a process for the manufacture of compound (I), wherein X is —Br or —Cl.
    Type: Grant
    Filed: September 13, 2012
    Date of Patent: September 10, 2013
    Assignee: Hoffmann-La Roche, Inc.
    Inventors: Stefan Hildbrand, Hans-Juergen Mair, Roumen Nikolaev Radinov, Yi Ren, James Anderson Wright
  • PROCESS FOR THE MANUFACTURE OF PHARMACEUTICALLY ACTIVE COMPOUNDS
    Publication number: 20130005761
    Abstract: The present invention relates to a composition comprising the compound of formula (1), and the compound of formula (B),
    Type: Application
    Filed: September 13, 2012
    Publication date: January 3, 2013
    Inventors: Stefan Hildbrand, Hans-Juergen Mair, Roumen Nikolaev Radinov, Yi Ren, James Anderson Wright
  • PROCESS FOR THE MANUFACTURE OF PHARMACEUTICALLY ACTIVE COMPOUNDS
    Publication number: 20130005978
    Abstract: The present invention further relates to a process for the manufacture of compound (I), wherein X is —Br or —Cl.
    Type: Application
    Filed: September 13, 2012
    Publication date: January 3, 2013
    Inventors: Stefan Hildbrand, Hans-Juergen Mair, Roumen Nikolaev Radinov, Yi Ren, James Anderson Wright
  • Process for the manufacture of pharmaceutically active compounds
    Patent number: 8329724
    Abstract: According to the present invention there are provided novel processes for the manufacture of the compound of formula 1 as well as novel synthesis routes for key intermediates used in those processes.
    Type: Grant
    Filed: July 27, 2010
    Date of Patent: December 11, 2012
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Stefan Hildbrand, Hans-Juergen Mair, Roumen Nikolaev Radinov, Yi Ren, James Anderson Wright
  • New Process
    Publication number: 20120157504
    Abstract: The present invention relates to a process for the preparation of S-[2-[1-(2-ethylbutyl)cyclohexylcarbonylamino]-phenyl]2-methylthiopropionate which is useful as a pharmaceutically active compound.
    Type: Application
    Filed: December 13, 2011
    Publication date: June 21, 2012
    Inventors: Hans-Juergen Mair, Reinhard Reents, Michelangelo Scalone, Shaoning Wang, Andreas Zogg
  • NOVEL PROCESS FOR THE MANUFACTURE OF PHARMACEUTICAL PREPARATIONS
    Publication number: 20110112136
    Abstract: The present invention is related to an improved method for the manufacture of Micro-precipitated Bulk Powder (MBP) containing the active pharmaceutical ingredient Propane-1-sulfonic acid {3-[5-(4-chloro-phenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide and Hydroxypropylmethylcellulose Acetate Succinate (HPMCAS). The invention is further directed to pharmaceutical compositions containing said MBP, as well as its use in the manufacture of medicaments for the treatment of cancer.
    Type: Application
    Filed: November 8, 2010
    Publication date: May 12, 2011
    Inventors: Ralph Diodone, Stephan Lauper, Hans-Juergen Mair, Johannes Pudewell, Frank Wierschem
  • PROCESS FOR THE MANUFACTURE OF PHARMACEUTICALLY ACTIVE COMPOUNDS
    Publication number: 20110028511
    Abstract: According to the present invention there are provided novel processes for the manufacture of the compound of formula 1 as well as novel synthesis routes for key intermediates used in those processes.
    Type: Application
    Filed: July 27, 2010
    Publication date: February 3, 2011
    Inventors: Stefan Hildbrand, Hans-Juergen Mair, Roumen Nikolaev Radinov, Yi Ren, James Anderson Wright
  • Processes for the manufacture of a pyrrolidine-3,4-dicarboxamide derivative
    Patent number: 7872141
    Abstract: The invention is concerned with processes for the manufacture of the pyrrolidine-3,4-dicarboxamide derivative of formula (I), and the intermediates useful for those processes of manufacture.
    Type: Grant
    Filed: December 19, 2007
    Date of Patent: January 18, 2011
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Jean-Michel Adam, Pascal Dott, Hans Iding, Hans-Juergen Mair, Reinhard Reents, Beat Wirz
  • Compositions and Uses Thereof
    Publication number: 20100310659
    Abstract: Provided are solid dispersions, solid molecular complexes, salts and crystalline polymorphs involving propane-1-sulfonic acid {3-[5-(4-chloro-phenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide.
    Type: Application
    Filed: March 31, 2010
    Publication date: December 9, 2010
    Inventors: Dipen Desai, Ralph Diodone, Zenaida Go, Prabha N. Ibrahim, Raman Iyer, Hans-Juergen Mair, Harpreet K. Sandhu, Navnit H. Shah, Gary Visor, Nicole Wyttenbach, Stephan Lauper, Johannes Pudewell, Frank Wierschem
  • PROCESSES FOR THE MANUFACTURE OF A PYRROLIDINE-3,4-DICARBOXAMIDE DERIVATIVE
    Publication number: 20080214826
    Abstract: The invention is concerned with processes for the manufacture of the pyrrolidine-3,4-dicarboxamide derivative of formula (I), and the intermediates useful for those processes of manufacture.
    Type: Application
    Filed: December 19, 2007
    Publication date: September 4, 2008
    Inventors: Jean-Michel Adam, Pascal Dott, Hans Iding, Hans-Juergen Mair, Reinhard Reents, Beat Wirz