Patents by Inventor Hans-Joachim Holtke

Hans-Joachim Holtke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6180948
    Abstract: Image recording system for the evaluation of analytical test elements with a holding unit (8) into which the test elements are placed or onto which they are placed as well as a lens system (5) which records an image of the test elements on a CCD chip (3) and an evaluation unit that evaluates the image on the CCD chip or displays it on a monitor. The image recording system enables numerous test elements of different sizes to be evaluated at different wavelengths without requiring focussing by the user. The lens system used for this is a reducing optical system with an aperture on the side of the image of at least 0.7 and a distance between the CCD chip and the nearest lens of the lens system of less than 15 mm. In addition the distance between the nearest lens of the lens system and the CCD chip is kept constant to at least 10 &mgr;m in order to ensure an adequate sharpness. A compensator is described for keeping this distance constant.
    Type: Grant
    Filed: January 25, 1999
    Date of Patent: January 30, 2001
    Assignee: Boehringer Mannheim GmbH
    Inventors: Martin Gutekunst, Hans-Joachim Höltke
  • Patent number: 6107036
    Abstract: Compounds of the general formula Ia and Ib are described ##STR1## in which R.sup.1 and R.sup.2 are the same or different and represent hydrogen, straight-chain or branched C.sub.1 to C.sub.6 lower alkyl or an aryl group optionally substituted by electron-withdrawing groups, R.sup.3 denotes a cleavable group, W is hydrogen, halogen or a pseudohalogen and at least one of the groups R.sup.4 or R.sup.5 is a group stabilizing the dioxetane structure and at most one of the groups R.sup.4 or R.sup.5 represents hydrogen and X or Y represents oxygen, N-R or C(R).sub.2 in which R has the meanings stated for R.sup.1 and R.sup.2 or represents a mesomeric double bond or a carbonyl group and n denotes the number 0 or 1 and m denotes the number 1 or 2, as well as a process for their production. These compounds are new and can be used as substrates in immunological assays and in DNA diagnostics using activating agents for colour formation.
    Type: Grant
    Filed: April 20, 1998
    Date of Patent: August 22, 2000
    Assignee: Roche Diagnostics GmbH
    Inventors: Dieter Heindl, Hans-Peter Josel, Herbert Von Der Eltz, Rupert Herrmann, Hans-Joachim Holtke, Rainer Beckert, Dieter Weiss, Waldemar Adam
  • Patent number: 5702888
    Abstract: For the detection of nucleic acids of definite sequence by hybridisation with a complementary nucleic acid probe which contains bound via a chemical bonding at least one hapten as labelling one uses, as hapten, a steroid which is bound vie a bridge of at least 4 atoms length to at least one position of the nucleic acid probe which does not participate in hydrogen bridge formation and detects the hybridised probe via an in turn labelled anti-hapten antibody.
    Type: Grant
    Filed: January 11, 1995
    Date of Patent: December 30, 1997
    Assignee: Boehringer Mannheim GmbH
    Inventors: Hans-Joachim Holtke, Rudolf Seibl, Gudrun Schmitz, Hans Robert Scholer, Christoph Kessler, Ralf Mattes
  • Patent number: 5344757
    Abstract: For the detection of nucleic acids of definite sequence by hybridisation with a complementary nucleic acid probe which contains bound via a chemical bonding at least one hapten as labelling one uses, as hapten, a steroid which is bound via a bridge of at least 4 atoms length to at least one position of the nucleic acid probe which does not participate in hydrogen bridge formation and detects the hybridised probe via an in turn labelled anti-hapten antibody.
    Type: Grant
    Filed: January 9, 1990
    Date of Patent: September 6, 1994
    Assignee: Boehringer Mannheim GmbH
    Inventors: Hans-Joachim Holtke, Rudolf Seibl, Gudrun Schmitz, Hans R. Scholer, Christoph Kessler, Ralf Mattes