Abstract: The invention includes new 2-amino-3a,4,5,6-tetrahydro-perimidines and method for their preparation from corresponding racemacic compounds. Also included in the invention are pharmaceutical compositions containing said 2-amino-3a,4,5,6-tetrahydro-perimidines and methods for the use of said compounds and compositions.

Abstract: 2-Carboxymethyl-3-carboxy-chromones and esters of the formula ##STR1## in which R, R.sup.1 and R.sup.2 each independently is hydrogen, an optionally substituted alkyl, alkenyl, cycloalkyl, cycloalkenyl, aralkyl or aryl group, halogen, hydroxyl, cyano or an optionally substituted alkoxy aryloxy, aralkoxy, alkoxy-carbonyl or dialkylamino group, orR and R.sup.1, together with two carbon atoms of the benzene ring system, form a carbocyclic or heterocyclic 5-membered or 6-membered ring, andR.sup.3 is hydrogen, optionally substituted alkyl, alkenyl, cycloalkyl, cycloalkenyl or aralkyl,are characterized by fungicidal and arthropodicidal activities. The novel compounds are produced by reacting an o-hydroxyacetophenone of the formula ##STR2## with a glyoxylic acid derivative of the formulaOCH-COOZin which Z is a cation, in the presence of a basic compound, followed by acidification to form the dicarboxylic acid and, optionally, the ester.

Abstract: 2-Carboxymethyl-3-carboxy-chromones and esters of the formula ##STR1## in which R, R.sup.1 and R.sup.2 each independently is hydrogen, an optionally substituted alkyl, alkenyl, cycloalkyl, cycloalkenyl, aralkyl or aryl group, halogen, hydroxyl, cyano or an optionally substituted alkoxy, aryloxy, aralkoxy, alkoxy-carbonyl or dialkylamino group, orR and R.sup.1, together with two carbon atoms of the benzene ring system, form a carbocyclic or heterocyclic 5-membered or 6-membered ring, andR.sup.3 is hydrogen, optionally substituted alkyl, alkenyl, cycloalkyl, cycloalkenyl or aralkyl,are characterized by fungicidal and arthropodicidal activities. The novel compounds are produced by reacting an o-hydroxyacetophenone of the formula ##STR2## with a glyoxylic acid derivative of the formulaOCH--COOZin whichZ is a cation,in the presence of a basic compound, followed by acidification to form the dicarboxylic acid and, optionally, the ester.

Abstract: Compounds useful in the treatment of cholesterolaemia are of the general formula ##STR1## or salts thereof in which R.sup.1 and R.sup.2 independently denote radicals including hydrogen, alkyl, aryl and heterocyclic radical or together complete a carbocyclic or heterocylic ring, R.sup.3 denotes a radical ##STR2## in which R.sup.9, R.sup.10 and R.sup.11 include hydrogen, cyano, nitro, alkyl and aryl or, in pairs, complete carbocyclic rings, X denotes cyano, nitro or substituted carbonyl, sulphonyl or phosphonyl group, R.sup.4 is hydrogen or a radical defined for R.sup.1 or R.sup.3, and R.sup.5, R.sup.6, R.sup.7 and R.sup.8 include hydrogen, nitro, cyano, carboxyl, alkyl and aryl or, in pairs, complete carbocyclic rings, with the proviso that R.sup.1 and R.sup.9 are not both phenyl if X denotes CO--C.sub.6 H.sub.6. The compounds exhibit considerably higher hypocholesterolaemic activity than the known clofibrate and in addition exhibit a pronounced nutritive effect, e.g., in a medicated fodder or premix.

Abstract: Chromane derivatives of the formula ##STR1## in which R.sup.1 to R.sup.4, which need not be identical, each represents hydrogen, an optionally substituted alkyl, alkenyl, cycloalkyl, aryl, aralkyl or alkoxycarbonyl radical, carboxyl or aminoalkyl,R.sup.2 can alternatively represent amino or optionally substituted dialkylamino, or R.sup.1 and R.sup.2 conjointly with the adjoining carbon atoms can form an optionally substituted carbocyclic or heterocyclic ring,R.sup.5 to R.sup.8, which need not be identical, each represents hydrogen, halogen, hydroxyl, nitro, cyano, carboxyl, an optionally substituted alkyl, alkenyl, cycloalkyl, aryl, aralkyl, alkoxy, aralkoxy, aryloxy, alkoxycarbonyl, alkylamino or dialkylamino radical, amino or acylamino, and two of the radicals, which are in the o-position to one another, can represent tetramethylene or the radical --CH.dbd.CH--CH.dbd.CH--, andX represents OH or the --NR.sup.9 R.sup.10 radical, whereinR.sup.9 and R.sup.

Abstract: Chromane derivatives of the formula ##STR1## in which R.sup.1 to R.sup.4, which need not be identical, each represents hydrogen, an optionally substituted alkyl, alkenyl, cycloalkyl, aryl, aralkyl or alkoxycarbonyl radical, carboxyl or aminoalkyl,R.sup.2 can alternatively represent amino or optionally substituted dialkylamino, or R.sup.1 and R.sup.2 conjointly with the adjoining carbon atoms can form an optionally substituted carbocyclic or heterocyclic ring,R.sup.5 to R.sup.8, which need not be identical, each represents hydrogen, halogen, hydroxyl, nitro, cyano, carboxyl, an optionally substituted alkyl, alkenyl, cycloalkyl, aryl, aralkyl, alkoxy, aralkoxy, aryloxy, alkoxycarbonyl, alkylamino or dialkylamino radical, amino or acylamino, and two of the radicals, which are in the o-position to one another, can represent tetramethylene or the radical --CH.dbd.CH--CH.dbd.CH--, andX represents OH or the --NR.sup.9 R.sup.10 radical,whereinR.sup.9 and R.sup.

Abstract: Pseudotrisaccharides of the sisomycin type are provided which are effective an antibacterial agents, particularly against gram-negative microorganisms. The invention also includes methods for the manufacture of the pseudotrisaccharides, compositions containing said pseudotrisaccharides and methods for the treatment of warm-blooded animals using said compounds and compositions.

Abstract: The invention includes selectively acylated or sulphenylated 4,6-O-(aminoglycosyl)-1,3-diaminocyclitols (and methods for their preparation). Also included in the invention are 1-N-acylated-derivatives, such as 1-N-formyl-sisomicin, useful because of the anti-bacterial effects (and methods for their procurement). The invention includes, furthermore, methods for the procurement of said 1-N-acylated or sulphenylated derivatives, compositions containing them and methods for their use.

Abstract: 2-Carboxymethyl-3-carboxy-chromones and esters of the formula ##STR1## in which R, R.sup.1 and R.sup.2 each independently is hydrogen, an optionally substituted alkyl, alkenyl, cycloalkyl, cycloalkenyl, aralkyl or aryl group, halogen, hydroxyl, cyano or an optionally substituted alkoxy, aryloxy, aralkoxy, alkoxy-carbonyl or dialkylamino group, orR and R.sup.1, together with two carbon atoms of the benzene ring system, form a carbocyclic or heterocyclic 5-membered or 6-membered ring, andR.sup.3 is hydrogen, optionally substituted alkyl, alkenyl, cycloalkyl, cycloalkenyl or aralkyl,are characterized by fungicidal and arthropodicidal activities. The novel compounds are produced by reacting an o-hydroxyacetophenone of the formula ##STR2## with a glyoxylic acid derivative of the formulaOCH--COOZin whichZ is a cation,in the presence of a basic compound, followed by acidification to form the dicarboxylic acid and, optionally, the ester.

Abstract: Known 2-substituted-chroman-4-ones of the formula ##STR1## wherein R.sup.1 to R.sup.4 each independently is hydrogen, various hydrocarbyl groups, alkoxycarbonyl, carboxyl or aminoalkyl, orR.sup.2 can also be an amino radical, orR.sup.1 and R.sup.2 can complete a carbocyclic or heterocyclic ring, andR.sup.5 to R.sup.8 each independently is hydrogen, halogen hydroxyl, nitro, cyano, carboxyl, various hydrocarbyl or hydrocarbyloxy groups, alkoxycarbonyl, alkylamino or acylaminoare effective in combating arthropods, being applied to the arthropods or their habitat such as soil, plants and domesticated animals.

Abstract: In the process for preparing an organic compound of the formulaA' -- Xin whichX is an amino group, a hydroxyl group or a carboxyl group, andA' is the remainder of the molecule, from an organic compound of the formulaA -- Xin whichA is the remainder of the molecule which can undergo reaction to form A', by converting A -- X into a compound of the formulaA -- Z -- COORin whichZ is --NH--, --O-- or a direct C--C bond, andR is a radical of the formula ##STR1## IN WHICH Y is a direct C--C single bond, the --CH.dbd.CH-- group or an arylene group,R.sup.1 to R.sup.4 each independently is hydrogen, halogen or an alkyl, aryl, aralkyl, alkoxycarbonyl, alkylaminocarbonyl, arylaminocarbonyl or cycloalkylaminocarbonyl radical, orR.sup.1 + r.sup.2 and R.sup.3 + R.sup.4 each independently completes a 5- or 6-membered carbocyclic ring, orR.sup.1 and R.sup.

Abstract: Benzoic acid amides characterized by the presence of a hydroxy or amino substituent in the phenyl ring, or an alkylated or acylated derivative thereof and by a heterocyclic group connected to the amide nitrogen atom through a hydrocarbon chain are antibacterial agents and in particular anti-tuberculosis agents. The compounds, of which N-[pyridyl-(2)-methyl]-2-hydroxybenzoic acid amide is a typical embodiment, are prepared by the reaction of an appropriately substituted benzoic acid, or derivative thereof, with an appropriate amine.

Abstract: 7-Acylaminodesacetoxycephalosporanic acid derivatives are produced by heating a penicillin ester S-oxide to a temperature between 60.degree. C and 150.degree. C in the presence of a heavy metal salt.

Abstract: Benzoic acid amides characterized by the presence of a nitro, cyano, trifluoromethyl, alkylsulfonyl, carboxy, carbalkoxy, amido or sulfonamido substituent in the phenyl ring and by the presence of a heterocyclic group connected to the amide nitrogen atom through a hydrocarbon chain are antibacterial agents and in particular antituberculosis agents. The compounds, of which N-(pyrid-2-yl-methyl)3,5-dinitrobenzoic acid amide is a typical embodiment, are prepared by the reaction of an appropriately substituted benzoic acid, or derivative thereof, with an appropriate amine.

Abstract: 7-Acylamino-desacetoxy-cephalosporanic acid esters are produced by heating a sulfoxide of 6-acylaminopenicillanic acid ester at a temperature of from about 60.degree.C to about 150.degree.C in the presence of a phenol catalyst. The 7-acylamino-desacetoxy-cephalosporanic acid esters produced are known per se and are useful as intermediates for the preparation of desacetoxy-cephalosporin derivatives which exhibit antibacterial activity.