Patents by Inventor Hans-Jorg Breyholz

Hans-Jorg Breyholz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Diagnostic imaging agents with MMP inhibitory activity
    Patent number: 8231858
    Abstract: The present invention relates to the field of diagnostic imaging. Specifically, the invention relates to the diagnostic imaging of diseases where specific matrix metalloproteinases are known to be involved. One embodiment of the invention is a compound having matrix metalloproteinase inhibitory activity suitable for diagnostic imaging. Also disclosed in the present invention is a pharmaceutical composition comprising the diagnostic imaging agent of the invention in a form suitable for mammalian administration. The invention furthermore discloses intermediates in the synthesis of the diagnostic imaging agents of the invention and kits for the preparation of the pharmaceutical composition of the invention. The pharmaceutical composition of the invention may be used in the diagnosis of diseases where specific matrix metalloproteinases are known to be involved.
    Type: Grant
    Filed: February 10, 2004
    Date of Patent: July 31, 2012
    Assignee: GE Healthcare Limited
    Inventors: Anthony Storey, Julie Davis, Sally-Ann Ricketts, Marivi Mendizabal, Alan Cuthbertson, Joseph Arukwe, Kirsty Heywood, Ian Wilson, Duncan Wynn, Michael Schafers, Bodo Levkau, Stefan Wagner, Hans-Jörg Breyholz, Klaus Kopka
  • Diagnostic imaging agents with mmp inhibitory activity
    Publication number: 20070071670
    Abstract: The present invention relates to the field of diagnostic imaging. Specifically, the invention relates to the diagnostic imaging of diseases where specific matrix metalloproteinases are known to be involved. One embodiment of the invention is a compound having matrix metalloproteinase inhibitory activity suitable for diagnostic imaging. Also disclosed in the present invention is a pharmaceutical composition comprising the diagnostic imaging agent of the invention in a form suitable for mammalian administration. The invention furthermore discloses intermediates in the synthesis of the diagnostic imaging agents of the invention and kits for the preparation of the pharmaceutical composition of the invention. The pharmaceutical composition of the invention may be used in the diagnosis of diseases where specific matrix metalloproteinases are known to be involved.
    Type: Application
    Filed: February 10, 2004
    Publication date: March 29, 2007
    Inventors: Anthony Storey, Julie Davis, Sally-Ann Ricketts, Marivi Medizabal, Alan Cuthbertson, Joseph Arukwe, Kirsty Heywood, Ian Wilson, Duncan Wynn, Michael Schafers, Bodu Levkau, Stefan Wagner, Hans-Jorg Breyholz, Klaus Kopka
  • Imaging agents comprising barbituric acid derivatives
    Publication number: 20060120956
    Abstract: The present invention relates to diagnostic imaging agents for in vivo imaging. The imaging agents comprise a synthetic barbituric acid derivative labelled at the 5-position with an imaging moiety suitable for diagnostic imaging in vivo. The invention also provides pharmaceutical and radiopharmaceutical compositions comprising the imaging agents, together with kits of the preparation of the radiopharmaceuticals. Also described are chelator conjugates of the barbituric acid derivative, which are suitable for the preparation of imaging agents comprising a radioactive or paramagnetic metal ion. The imaging agents are useful for the diagnostic imaging in vivo of various disease states, including atherosclerosis.
    Type: Application
    Filed: October 8, 2003
    Publication date: June 8, 2006
    Inventors: Klaus Kopka, Hans-Jorg Breyholz, Stefan Wagner, Michael Shafers, Bodo Leykau, Benedicte Guilbert, Duncan Wynn