Patents by Inventor Hans-Jurgen Ernst Hess

Hans-Jurgen Ernst Hess has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PHOSPHODIESTERASE 4 INHIBITORS
    Publication number: 20100010020
    Abstract: PDE4 inhibition is achieved by novel compounds of the Formula I: wherein R1 and R2 are as defined herein.
    Type: Application
    Filed: September 22, 2009
    Publication date: January 14, 2010
    Inventors: Ruiping LIU, Hans-Jurgen Ernst Hess, Allen Hopper, Ashok Tehim, Yujing Rong
  • PHOSPHODIESTERASE 4 INHIBITORS
    Publication number: 20090176799
    Abstract: Selective PDE4 inhibition is achieved by 4-(substituted-phenyl)-2-pyrrolidinone compounds. The compounds exhibit improved PDE4 inhibition as compared to compounds like rolipram and show selectivity with regard to inhibition of other classes of PDEs. The compounds of the present invention are of formula I: wherein R1, R2, and R3 are as defined herein.
    Type: Application
    Filed: December 1, 2008
    Publication date: July 9, 2009
    Inventors: Liu Ruiping, Mike De Vivo, Hans-Jurgen Ernst Hess, Allen Hopper, Erik Kreuster, Ashok Tehim
  • PHOSPHODIESTERASE 4 INHIBITORS, INCLUDING N-SUBSTITUTED ANILINE AND DIPHENYLAMINE ANALOGS
    Publication number: 20090048255
    Abstract: PDE4 inhibition is achieved by novel compounds, e.g., N-substituted aniline and diphenylamine analogs. The compounds of the present invention are of Formula I: wherein R1, R2, R3 and R4 are as defined herein.
    Type: Application
    Filed: July 17, 2008
    Publication date: February 19, 2009
    Inventors: Richard A. SCHUMACHER, Allen T. HOPPER, Ashok TEHIM, Hans-Jurgen Ernst HESS, Axel UNTERBECK, Erik KUESTER, William Frederick BRUBAKER, JR., Robert F. DUNN
  • Phosphodiesterase 4 inhibitors, including N-substituted aniline and diphenylamine analogs
    Patent number: 7405230
    Abstract: PDE4 inhibition is achieved by novel compounds, e.g., N-substituted aniline and diphenylamine analogs. The compounds of the present invention are of Formula I: wherein R1, R2, R3 and R4 are as defined herein.
    Type: Grant
    Filed: July 21, 2003
    Date of Patent: July 29, 2008
    Assignee: Memory Pharmaceuticals Corporation
    Inventors: Richard A. Schumacher, Allen T. Hopper, Ashok Tehim, Hans-Jurgen Ernst Hess, Axel Unterbeck, Erik Kuester, William Frederick Brubaker, Jr., Robert F. Dunn
  • PHOSPHODIESTERASE 4 INHIBITORS
    Publication number: 20080139583
    Abstract: PDE4 inhibition is achieved by novel compounds of the Formula I: wherein R1 and R2 are as defined herein.
    Type: Application
    Filed: February 5, 2008
    Publication date: June 12, 2008
    Inventors: Ashok Tehim, Allen T. HOPPER, Ruiping Liu, Hans-Jurgen Ernst Hess, Yajing Rong
  • PHOSPHODIESTERASE 4 INHIBITORS
    Publication number: 20080119495
    Abstract: PDE4 inhibition is achieved by novel compounds of the Formula I: wherein R1 and R2 are as defined herein.
    Type: Application
    Filed: December 14, 2007
    Publication date: May 22, 2008
    Inventors: Ruiping LIU, Hans-Jurgen Ernst Hess, Allen Hopper, Ashok Tehim, Yajing Rong
  • Phosphodiesterase 4 inhibitors
    Patent number: 7342021
    Abstract: PDE4 inhibition is achieved by novel compounds of the Formula I: wherein R1 and R2 are as defined herein.
    Type: Grant
    Filed: February 8, 2002
    Date of Patent: March 11, 2008
    Assignee: Memory Pharmaceuticals Corp.
    Inventors: Ruiping Liu, Hans-Jurgen Ernst Hess, Allen Hopper, Ashok Tehim, Yajing Rong
  • Phosphodiesterase 4 inhibitors
    Patent number: 7332486
    Abstract: PDE4 inhibition is achieved by novel compounds of the Formula I: wherein R1 and R2 are as defined herein.
    Type: Grant
    Filed: August 8, 2003
    Date of Patent: February 19, 2008
    Assignee: Memory Pharmaceuticals Corp.
    Inventors: Ashok Tehim, Allen T. Hopper, Ruiping Liu, Hans-Jurgen Ernst Hess, Yajing Rong
  • Phosphodiesterase 4 inhibitors
    Patent number: 7235579
    Abstract: Selective PDE4 inhibition is achieved by 4-(substituted-phenyl)-2-pyrrolidinone compounds. The compounds exhibit improved PDE4 inhibition as compared to compounds like rolipram and show selectivity with regard to inhibition of other classes of PDEs. The compounds of the present invention are of formula I: wherein R1, R2, and R3 are as defined herein.
    Type: Grant
    Filed: October 16, 2002
    Date of Patent: June 26, 2007
    Assignee: Memory Pharmaceuticals Corp.
    Inventors: Ruiping Liu, Mike De Vivo, Hans-Jurgen Ernst Hess, Allen Hopper, Erik Kuester, Ashok Tehim
  • Phosphodiesterase 4 inhibitors
    Patent number: 7205320
    Abstract: PDE4 inhibition is achieved by novel compounds, e.g., N-substituted aniline and diphenylamine analogs. The compounds of the present invention are of Formula I: wherein R1, R2, R3 and R4 are as defined herein.
    Type: Grant
    Filed: January 12, 2004
    Date of Patent: April 17, 2007
    Assignee: Memory Pharmaceuticals Corp.
    Inventors: Richard A. Schumacher, William F. Brubaker, Michael De Vivo, Hans-Jürgen Ernst Hess, Allen Hopper, Ashok Tehim, Ruiping Liu, Axel Unterbeck
  • Phosphodiesterase 4 inhibitors
    Publication number: 20050272803
    Abstract: Selective PDE4 inhibition is achieved by 4-(substituted-phenyl)-2-pyrrolidinone compounds. The compounds exhibit improved PDE4 inhibition as compared to compounds like rolipram and show selectivity with regard to inhibition of other classes of PDEs. The compounds of the present invention are of formula I: wherein R1, R2, and R3 are as defined herein.
    Type: Application
    Filed: July 22, 2005
    Publication date: December 8, 2005
    Inventors: Liu Ruiping, Mike De Vivo, Hans-Jurgen Ernst Hess, Allen Hopper, Erik Kreuster, Ashok Tehim
  • Phosphodiesterase 4 inhibitors
    Publication number: 20040242598
    Abstract: PDE4 inhibition is achieved by novel compounds of the Formula I: 1
    Type: Application
    Filed: May 14, 2004
    Publication date: December 2, 2004
    Inventors: Ruiping Liu, Hans-Jurgen Ernst Hess, Allen Hopper, Ashok Tehim, Yajing Rong
  • Phosphodiesterase 4 inhibitors
    Publication number: 20040230072
    Abstract: PDE4 inhibition is achieved by novel compounds, e.g., N-substituted aniline and diphenylamine analogs.
    Type: Application
    Filed: January 12, 2004
    Publication date: November 18, 2004
    Inventors: Richard A. Schumacher, William F. Brubaker, Michael De Vivo, Hans-Jurgen Ernst Hess, Allen Hopper, Ashok Tehim, Ruiping Liu, Axel Unterbeck
  • Phosphodiesterase 4 inhibitors
    Patent number: 6699890
    Abstract: PDE4 inhibition is achieved by novel compounds, e.g., N-substituted aniline and diphenylamine analogs. The compounds of the present invention are of Formula I: wherein R1, R2 , R3 and R4 are as defined herein.
    Type: Grant
    Filed: January 22, 2002
    Date of Patent: March 2, 2004
    Assignee: Memory Pharmaceuticals Corp.
    Inventors: Richard A. Schumacher, William F. Brubaker, Michael De Vivo, Hans-Jürgen Ernst Hess, Allen Hopper, Ashok Tehim, Ruiping Liu, Axel Unterbeck
  • Phosphodiesterase 4 inhibitors
    Publication number: 20030149052
    Abstract: PDE4 inhibition is achieved by novel compounds, e.g., N-substituted aniline and diphenylamine analogs.
    Type: Application
    Filed: February 11, 2003
    Publication date: August 7, 2003
    Applicant: MEMORY PHARMACEUTICALS CORP.
    Inventors: Richard A. Schumacher, William F. Brubaker, Michael De Vivo, Hans-Jurgen Ernst Hess, Allen Hopper, Ashok Tehim, Ruiping Liu, Axel Unterbeck
  • Phosphodiesterase 4 inhibitors
    Publication number: 20030139406
    Abstract: Selective PDE4 inhibition is achieved by 4-(substituted-phenyl)-2-pyrrolidinone compounds. The compounds exhibit improved PDE4 inhibition as compared to compounds like rolipram and show selectivity with regard to inhibition of other classes of PDEs.
    Type: Application
    Filed: October 16, 2002
    Publication date: July 24, 2003
    Applicant: MEMORY PHARMACEUTICALS CORP.
    Inventors: Ruiping Liu, Mike De Vivo, Hans-Jurgen Ernst Hess, Allen Hopper, Erik Kreuster, Ashok Tehim
  • Phosphodiesterase 4 inhibitors
    Publication number: 20030045533
    Abstract: PDE4 inhibition is achieved by novel compounds of the Formula I: 1
    Type: Application
    Filed: February 8, 2002
    Publication date: March 6, 2003
    Applicant: MEMORY PHARMACEUTICALS CORP.
    Inventors: Ruiping Liu, Hans-Jurgen Ernst Hess, Allen Hopper, Ashok Tehim, Yajing Rong
  • Phosphodiesterase 4 inhibitors
    Publication number: 20020151566
    Abstract: PDE4 inhibition is achieved by novel compounds, e.g., N-substituted aniline and diphenylamine analogs.
    Type: Application
    Filed: January 22, 2002
    Publication date: October 17, 2002
    Applicant: MEMORY PHARMACEUTICALS CORP.
    Inventors: Richard A. Schumacher, William F. Brubaker, Michael De Vivo, Hans-Jurgen Ernst Hess, Allen Hopper, Ashok Tehim, Ruiping Liu, Axel Unterbeck
  • Relaxation of smooth muscle in a mammal
    Patent number: 3950525
    Abstract: 4-Amino-6-arylpyrimidines and salts thereof, a novel class of inhibitors of platelet aggregation and broncho-dilators in mammals, and 4-hydroxy-6-arylpyrimidines as useful intermediates.
    Type: Grant
    Filed: April 11, 1975
    Date of Patent: April 13, 1976
    Assignee: Pfizer Inc.
    Inventors: Gerald George De Angelis, Hans-Jurgen Ernst Hess