Patents by Inventor Hans Keegstra

Hans Keegstra has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Formulations of 6-mercaptopurine
    Patent number: 10525009
    Abstract: The present invention provides improved formulations of 6-mercaptopurine that exhibit better bioavailability and faster dissolution than previous formulations.
    Type: Grant
    Filed: June 17, 2016
    Date of Patent: January 7, 2020
    Assignee: Hadasit Medical Research Services and Development Ltd.
    Inventors: Itzhak E. Lerner, Moshe Flashner-Barak, Erwin v Achthoven, Hans Keegstra, Ruud Smit
  • FORMULATIONS OF 6-MERCAPTOPURINE
    Publication number: 20160296473
    Abstract: The present invention provides improved formulations of 6-mercaptopurine that exhibit better bioavailability and faster dissolution than previous formulations.
    Type: Application
    Filed: June 17, 2016
    Publication date: October 13, 2016
    Applicant: TEVA PHARMACEUTICAL INDUSTRIES LTD.
    Inventors: E. Itzhak Lerner, Moshe Flashner-Barak, Erwin v Achthoven, Hans Keegstra, Ruud Smit
  • Formulations of 6-mercaptopurine
    Patent number: 9375403
    Abstract: The present invention provides improved formulations of 6-mercaptopurine that exhibit better bioavailability and faster dissolution than previous formulations.
    Type: Grant
    Filed: June 25, 2015
    Date of Patent: June 28, 2016
    Assignee: TEVA PHARMACEUTICAL INDUSTRIES LTD.
    Inventors: E. Itzhak Lerner, Moshe Flashner-Barak, Erwin v Achthoven, Hans Keegstra, Ruud Smit
  • Formulations of 6-mercaptopurine
    Patent number: 9180097
    Abstract: The present invention provides improved formulations of 6-mercaptopurine that exhibit better bioavailability and faster dissolution than previous formulations.
    Type: Grant
    Filed: February 10, 2014
    Date of Patent: November 10, 2015
    Assignee: TEVA PHARMACEUTICAL INDUSTRIES LTD.
    Inventors: E. Itzhak Lerner, Moshe Flashner-Barak, Erwin v. Achthoven, Hans Keegstra, Ruud Smit
  • FORMULATIONS OF 6-MERCAPTOPURINE
    Publication number: 20150290133
    Abstract: The present invention provides improved formulations of 6-mercaptopurine that exhibit better bioavailability and faster dissolution than previous formulations.
    Type: Application
    Filed: June 25, 2015
    Publication date: October 15, 2015
    Applicant: TEVA PHARMACEUTICAL INDUSTRIES LTD.
    Inventors: E. Itzhak Lerner, Moshe Flashner-Barak, Erwin v Achthoven, Hans Keegstra, Ruud Smit
  • FORMULATIONS OF 6-MERCAPTOPURINE
    Publication number: 20140161888
    Abstract: The present invention provides improved formulations of 6-mercaptopurine that exhibit better bioavailability and faster dissolution than previous formulations.
    Type: Application
    Filed: February 10, 2014
    Publication date: June 12, 2014
    Applicant: TEVA PHARMACEUTICAL INDUSTRIES LTD.
    Inventors: E. Itzhak Lerner, Moshe Flashner-Barak, Erwin v Achthoven, Hans Keegstra, Ruud Smit
  • Formulations of 6-mercaptopurine
    Patent number: 8653060
    Abstract: The present invention provides improved formulations of 6-mercaptopurine that exhibit better bioavailability and faster dissolution than previous formulations.
    Type: Grant
    Filed: April 25, 2012
    Date of Patent: February 18, 2014
    Assignee: Teva Pharmaceutical Industries Ltd.
    Inventors: E. Itzhak Lerner, Moshe Flashner-Barak, Erwin v Achthoven, Hans Keegstra, Ruud Smit
  • FORMULATIONS OF 6-MERCAPTOPURINE
    Publication number: 20120207841
    Abstract: The present invention provides improved formulations of 6-mercaptopurine that exhibit better bioavailability and faster dissolution than previous formulations.
    Type: Application
    Filed: April 25, 2012
    Publication date: August 16, 2012
    Inventors: E. Itzhak Lerner, Moshe Flashner-Barak, Erwin v Achthoven, Hans Keegstra, Ruud Smit
  • Formulations of 6-mercaptopurine
    Patent number: 8188067
    Abstract: The present invention provides improved formulations of 6-mercaptopurine that exhibit better bioavailability and faster dissolution than previous formulations.
    Type: Grant
    Filed: April 1, 2005
    Date of Patent: May 29, 2012
    Assignee: Teva Pharmaceutical Industries Ltd.
    Inventors: E. Itzhak Lerner, Moshe Flashner-Barak, Erwin v Achthoven, Hans Keegstra, Ruud Smit
  • Delayed release formulations of 6-mercaptopurine
    Publication number: 20090042914
    Abstract: The present invention provides enterically coated formulations of 6-mercaptopurine that exhibit a delay in release of the 6-mercaptopurine such that substantial release of 6-mercaptopurine does not occur until after passage through the stomach. Optionally, the formulations also comprise a delay coating in addition to the enteric coating that provides an even further delay such that substantial release of 6-mercaptopurine does not occur until after a certain period of time following passage through the stomach. Such a period of time is preferably at least one hour after passage through the stomach. Following the delay imparted by the enteric coating and optional delay coating, the formulations exhibit better bioavailability and faster dissolution than previous formulations.
    Type: Application
    Filed: June 30, 2008
    Publication date: February 12, 2009
    Inventors: E. Itzhak Lerner, Moshe Flashner-Barak, Erwin V. Achthoven, Hans Keegstra, Ruud Smit
  • Drug microparticles
    Publication number: 20080057129
    Abstract: Pharmaceutical compositions are described containing carrier particles bearing microparticles of a drug. The drug microparticles may be deposited on the carrier particles, for example, by sublimation. Preferred embodiments of these pharmaceutical compositions are suitable for administration by inhalation or injection. Methods for treating lung infection in patients with cystic fibrosis through inhalation of, for example, calcitriol compositions, are also described.
    Type: Application
    Filed: April 3, 2007
    Publication date: March 6, 2008
    Inventors: E. Lerner, Moshe Flashner-Barak, Ruud Smit, Richard Van Lamoen, Erwin Van Achthoven, Hans Keegstra
  • Formulations of 6-mercaptopurine
    Publication number: 20060009473
    Abstract: The present invention provides improved formulations of 6-mercaptopurine that exhibit better bioavailability and faster dissolution than previous formulations.
    Type: Application
    Filed: April 1, 2005
    Publication date: January 12, 2006
    Inventors: E. Lerner, Moshe Flashner-Barak, Erwin Achthoven, Hans Keegstra, Ruud Smit
  • Delayed release formulations of 6-mercaptopurine
    Publication number: 20060008520
    Abstract: The present invention provides enterically coated formulations of 6-mercaptopurine that exhibit a delay in release of the 6-mercaptopurine such that substantial release of 6-mercaptopurine does not occur until after passage through the stomach. Optionally, the formulations also comprise a delay coating in addition to the enteric coating that provides an even further delay such that substantial release of 6-mercaptopurine does not occur until after a certain period of time following passage through the stomach. Such a period of time is preferably at least one hour after passage through the stomach. Following the delay imparted by the enteric coating and optional delay coating, the formulations exhibit better bioavailability and faster dissolution than previous formulations.
    Type: Application
    Filed: April 1, 2005
    Publication date: January 12, 2006
    Inventors: E. Lerner, Moshe Flashner-Barak, Erwin v Achthoven, Hans Keegstra, Ruud Smit