Patents by Inventor Hans Kobel

Hans Kobel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cyclosporin fermentation process
    Patent number: 6255100
    Abstract: It has been found that nonimmunosuppressive, cyclophilin-binding cyclosporins are useful in the treatment and prevention of AIDS and AIDS-related disorders. Such cyclosporins include novel Ciclosporin derivatives modified at the 4- and/or 5-positions.
    Type: Grant
    Filed: September 9, 1999
    Date of Patent: July 3, 2001
    Assignee: Novartis AG
    Inventors: Soo Young Ko, Hans Kobel, Brigitte Besemer-Rosenwirth, Dieter Seebach, RenéP. Traber, Roland Wenger, Pietro Bollinger
  • Cyclosporins
    Patent number: 5981479
    Abstract: It has been found that nonimmunosuppressive, cyclophilin-binding cyclosporins are useful in the treatment and prevention of AIDS and AIDS-related disorders. Such cyclosporins include novel Ciclosporin derivatives modified at the 4- and/or 5-positions.
    Type: Grant
    Filed: May 26, 1998
    Date of Patent: November 9, 1999
    Assignee: Novartis AG
    Inventors: Soo Young Ko, Hans Kobel, Brigitte Besemer-Rosenwirth, Dieter Seebach, Rene P. Traber, Roland Wenger, Pietro Bollinger
  • Cyclosporins
    Patent number: 5767069
    Abstract: Nonimmunosuppressant cyclosporin derivatives having cyclophilin-binding activity, for example, the compound, ?MeIle!.sup.4 -ciclosporin, are useful in inhibiting HIV-1 replication in treating AIDS and AIDS related disorders.
    Type: Grant
    Filed: April 24, 1995
    Date of Patent: June 16, 1998
    Assignee: Novartis AG
    Inventors: Soo Young Ko, Hans Kobel, Brigitte Besemer-Rosenwirth, Dieter Seebach, Rene P. Traber, Roland Wenger, Pietro Bollinger
  • Ergot cyclic peptide alkaloids having a venotonizing effect, useful for treating orthostatic hypotension
    Patent number: 4804660
    Abstract: 9-thia ergot cyclic peptide alkaloids produced by fermentation or synthetic methods have interesting anti-parkinson and other pharmacological activities.
    Type: Grant
    Filed: May 5, 1987
    Date of Patent: February 14, 1989
    Assignee: Sandoz Ltd.
    Inventors: Hans Kobel, Jean-Jacques Sanglier, Hans Tscherter, Georg Bolliger
  • Use of thio isosteres of ergot peptide alkaloids as vasaconstrictors
    Patent number: 4681880
    Abstract: 9-thia ergot cyclic peptide alkaloids produced by fermentation or synthetic methods have interesting anti-parkinson and other pharmacological activities.
    Type: Grant
    Filed: July 2, 1985
    Date of Patent: July 21, 1987
    Assignee: Sandoz Ltd.
    Inventors: Hans Kobel, Jean-Jacques Sanglier, Hans Tscherter, Georg Bolliger
  • Novel cyclosporins
    Patent number: 4639434
    Abstract: Cyclosporins wherein the amino acid residue at the 8-position is a (D)-acyloxy-.alpha.-amino acid residue, typically of formula ##STR1## wherein X=-MeBmt- or -dihydro-MeBmt-, Y=-.alpha.Abu-, -Ala-, -Thr-, -Val- or -Nva-, Z=-Val- or -Nva- and Q=R.sub.1 --CO--O--CH(R.sub.2)--CH(CO--)--NH--wherein R.sub.1 =H, C.sub.1-4 alkyl or phenyl and R.sub.2 =H or CH.sub.3, possess immunosuppressive, anti-inflammatory and anti-parasitic activity.
    Type: Grant
    Filed: March 19, 1985
    Date of Patent: January 27, 1987
    Assignee: Sandoz Ltd.
    Inventors: Roland Wenger, Rene P. Traber, Hans Kobel, Hans Hofmann
  • 9'Thia-ergots
    Patent number: 4542135
    Abstract: 9-Thia ergot cyclic peptide alkaloids produced by fermentation or synthetic methods have interesting anti-parkinson and other pharmacological activities.
    Type: Grant
    Filed: August 3, 1982
    Date of Patent: September 17, 1985
    Assignee: Sandoz Ltd.
    Inventors: Hans Kobel, Jean-Jacques Sanglier, Hans Tscherter, Georg Bolliger
  • Novel cyclosporins
    Patent number: 4384996
    Abstract: Novel cyclosporins having an -Allylgly- residue in the 2-position and/or a -(D)-Ser- residue in the 8-position and process for their production. The novel cyclosporins are useful as pharmaceuticals, e.g. as immunosuppressive and anti-inflammatory agents.
    Type: Grant
    Filed: January 6, 1982
    Date of Patent: May 24, 1983
    Assignee: Sandoz Ltd.
    Inventors: Pietro Bollinger, Johann J. Bolsterli, Hans Kobel