Patents by Inventor Hans L. Hansen

Hans L. Hansen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Thiolation of peptides for radionuclide-based radiodetection and radiotherapy
    Patent number: 5746996
    Abstract: A method of radiolabeling a peptide, e.g., somatostatin or an analogue thereof or vasoactive intestinal peptide, with a radioisotope of technetium or rhenium, comprises the steps of: (a) reacting the peptide with an acetyl-protected t-thiol-containing, amine-reactive bifunctional chelating agent; (b) deprotecting the acetyl-t-thiol group to generate a free t-thiol group; and either (c) admixing the peptide-t-thiol-containing conjugate with a stannous salt; and (d) reacting the mixture of step (c) with pertechnetate or perrhenate, or (c') adding reduced pertechnetate or perrhenate to said peptide-t-thiol-containing conjugate, thereby forming a radiolabeled peptide. Kits for effecting the radiolabeling method, and methods of tumor detection/imaging or therapy are provided.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: May 5, 1998
    Assignee: Immunomedics, Inc.
    Inventors: Serengulam V. Govindan, Gary L. Griffiths, Hans L. Hansen
  • Rotary piston machine with parallel internal axes
    Patent number: 4597725
    Abstract: A ring and star type gear set is disclosed with recessed passages 32 that serve to communicate the fluid chambers about the line of eccentricity.
    Type: Grant
    Filed: January 17, 1985
    Date of Patent: July 1, 1986
    Assignee: Danfoss A/S
    Inventors: Hans C. Petersen, Svend E. Thomsen, Hans L. Hansen