Patents by Inventor Hans Lindel
Hans Lindel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5648495Abstract: The present invention relates to a process for the preparation of 5-substituted 2-chloropyridines of the formula (I) ##STR1## by reaction of acetenamides of the formula (II) ##STR2## with Vilsmeier reagent, which is prepared by reaction of dialkylformamides of the formula (III) ##STR3## with a chlorinating agent, the excess of which is removed from the reaction mixture by distillation or by addition of dialkylformamide after completion of the reaction of the Vilsmeier reagent with the acetenamide of the formula (II), wherein in the formulae (I)-(III):R represents optionally substituted alkyl or aralkyl,R.sup.1 represents C.sub.1 -C.sub.4 -alkyl or aryl-C.sub.1 -C.sub.4 -alkyl,R.sup.2 and R.sup.3 represent straight-chain, branched or cyclic C.sub.4 -C.sub.8 -alkyl.Type: GrantFiled: January 11, 1996Date of Patent: July 15, 1997Assignee: Bayer AktiengesellschaftInventors: Klaus Jelich, Hans Lindel, Christoph Mannheims, Reinhard Lantzsch, Walter Merz
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Patent number: 5442072Abstract: The invention relates to a novel process for preparing chloromethylpyridines of the general formula (I) ##STR1## in which n represents the numbers 0,1,2 or 3 andX represents halogen,by reacting aminomethylpyridines of the general formula (II) ##STR2## with a nitrosating or diazotizing agent in the presence of a diluent and optionally in the presence of hydrogen chloride at temperatures between -20.degree. C. and +50.degree. C. and then working up in a conventional manner.Type: GrantFiled: June 24, 1994Date of Patent: August 15, 1995Assignee: Bayer AktiengesellschaftInventors: Helmut Kraus, Hans Lindel, Hans-Joachim Diehr
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Patent number: 5283338Abstract: 2-Chloropyridine derivatives of the formula (I) ##STR1## in which R represents hydrogen, C.sub.1 -C.sub.4 -alkyl or halogen andn represents 0 to 4,are obtained in good yields and high purity when a 2-aminopyridine derivative of the formula (II) ##STR2## in which R and n have the above definitions,is reacted with nitrosyl chloride in a hydrogen chloride-saturated aqueous solution at temperatures between -10.degree. C. and +50.degree. C. with simultaneous introduction of hydrogen chloride.Type: GrantFiled: April 1, 1992Date of Patent: February 1, 1994Assignee: Bayer AktiengesellschaftInventors: Gunther Cramm, Hans Lindel, Guido Steffan
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Patent number: 5216170Abstract: A compound for promoting livestock production and for controlling obesity in humans and animals, of the formula ##STR1## in which A represents .dbd.CH-- or .dbd.N--,R.sup.0 represents hydrogen or methyl,R.sup.1 and R.sup.3 each independently represents hydrogen, hydroxyl, halogen, cyano, alkyl, halogenoalkyl, hydroxyalkyl, alkoxycarbonyl, aminocarbonyl, mono- and dialkylaminocarbonyl, alkoxy, halogenoalkoxy, halogenoalkylthio, NHSO.sub.2 -alkyl,R.sup.2 represents hydrogen, hydroxyl, alkoxy or the radical --NR.sup.5 R.sup.6,R.sup.4 represents hydrogen, C.sub.1 -C.sub.10 -alkyl which is optionally substituted by hydroxyl, halogen, alkoxy, acyloxy or the radical --NR.sup.7 R.sup.8, or represents the radical COR.sup.9 or the radical --O--Z--R.sup.10,Z represents C.sub.1 -C.sub.10 -alkylene, -alkenylene or alkynylene,R.sup.5 represents hydrogen or alkyl,R.sup.6 represents hydrogen, alkyl, halogenoalkyl or acyl, or R.sup.5 and R.sup.Type: GrantFiled: March 28, 1991Date of Patent: June 1, 1993Assignee: Bayer AktiengesellschaftInventors: Hans Lindel, Werner Hallenbach, Friedrich Berschauer, Heinrich A. Greife, Gernot Klotz
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Patent number: 5149822Abstract: A process for the preparation of 2,3-dichloro-5-acetylpyridine of the formula ##STR1## comprising decarboxylating a compound of the formula ##STR2## in which R.sup.1 stands for methyl or ethyl,in a mixture of water and a water miscible aprotic solvent.Type: GrantFiled: April 12, 1989Date of Patent: September 22, 1992Assignee: Bayer AktiengesellschaftInventors: Hans Lindel, Werner Hallenbach, Bernd Gallenkamp
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Patent number: 5091068Abstract: A process for the preparation of 3-trichloromethylpyridine of the formula ##STR1## which comprises reacting 3-methyl-pyridine hydrogen sulphate of the formula ##STR2## with elemental chlorine which exposure to at least one of visible and ultraviolet light at a temperature between about 70.degree. C. and 150.degree. C.Type: GrantFiled: September 28, 1990Date of Patent: February 25, 1992Assignee: Bayer AktiengesellschaftInventors: Klaus Jelich, Hans Lindel
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Patent number: 5086181Abstract: A pyridine derivative of the formula ##STR1## in which A stands for ##STR2## is useful in the preparation of 4-bromo-6-chloro-5-amino-2-pyridyl-ethanolamines, their physiologically tolerated salts and their N-oxides. The 4-bromo-6-chloro-5-amino-2-pyridyl-ethanolamines are useful as yield promoters in animals and as feedstuff additives to achieve higher increases in weight and improved feed utilization.Type: GrantFiled: September 13, 1990Date of Patent: February 4, 1992Assignee: Bayer AktiengesellschaftInventors: Hans Lindel, Werner Hallenbach, Friedrich Berschauer, Gernot Klotz, Heinrich A. Greife
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Patent number: 5028617Abstract: A compound for promoting livestock production and for controlling obesity in humans and animals, of the formula ##STR1## in which A represents .dbd.CH-- or .dbd.N--,R.sup.0 represents hydrogen or methyl,R.sup.1 and R.sup.3 each independently represents hydrogen, hydroxyl, halogen, cyano, alkyl, halogenoalkyl, hydroxyalkyl, alkoxycarbonyl, aminocarbonyl, mono- and dialkylaminocarbonyl, alkoxy, halogenoalkoxy, halogenoalkylthio, NHSO.sub.2 -alkyl,R.sup.2 represents hydrogen, hydroxyl, alkoxy or the radical --NR.sup.5 R.sup.6,R.sup.4 represents hydrogen, C.sub.1 -C.sub.10 -alkyl which is optionally substituted by hydroxyl, halogen, alkoxy, acyloxy or the radical --NH.sup.7 R.sup.8, or represents the radical COR.sup.9 or the radical --O--Z--R.sup.10,Z represents C.sub.1 -C.sub.10 -alkylene, -alkenylene or alkynylene,R.sup.5 represents hydrogen or alkyl,R.sup.6 represents hydrogen, alkyl, halogenoalkyl or acyl, or R.sup.5 and R.sup.Type: GrantFiled: January 19, 1990Date of Patent: July 2, 1991Assignee: Bayer AktiengesellschaftInventors: Hans Lindel, Werner Hallenbach, Friedrich Berschauer, Heinrich A. Greife, Gernot Klotz
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Patent number: 5010091Abstract: 2,4-dihalogeno-6-pyridylethanolphenylisopropylamines for shifting the protein-fat ratio of animals in favor of protein, of the formula ##STR1## in which Hal are identical or different and represent fluorine, chlorine or bromine,X represents a direct bond or --CH.sub.2 -- andY represents phenyl, which is substituted by OH, C.sub.1-4 -alkoxy, C.sub.1-4 -alkoxy-C.sub.1-4 -alkoxy, carboxyl, aminocarbonyl, C.sub.1-4 -alkoxycarbonyl, hydroxy-C.sub.1-4 -alkoxy, C.sub.1-4 -alkoxycarbonyl-C.sub.1-4 -alkoxy or phenyl-C.sub.1-4 -alkoxy,or their physiologically tolerated salts.Type: GrantFiled: February 8, 1990Date of Patent: April 23, 1991Assignee: Bayer AktiengesellschaftInventors: Hans Lindel, Werner Hallenbach, Friedrich Berschauer, Heinrich Greife, Gernot Klotz
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Patent number: 4990620Abstract: R.sup.2 is halogen,R.sup.3 is alkyl,R.sup.4 is C.sub.1-3 -alkyl,R.sup.5 is hydrogen or C.sub.1-2 -alkyl,R.sup.6 is C.sub.1-3 -alkyl, andHal is halogen.The process is new as are intermediates II, IV and V. The products are known intermediates.Type: GrantFiled: January 24, 1990Date of Patent: February 5, 1991Assignee: Bayer AktiengesellschaftInventors: Hans Lindel, Werner Hallenbach
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Patent number: 4988694Abstract: 4-Bromo-6-chloro-5-amino-2-pyridyl-ethanolamines, intermediates for preparation thereof and their use as yield promoters for animals and as feedstuff additives to achieve higher increases in weight and improved feed utilization of the formula ##STR1## in which R.sup.1 stands for hydrogen, alkyl, acyl or substituted silyl,R.sup.2 stands for hydrogen or alkyl,R.sup.3 stands for hydrogen, alkyl, cycloalkyl, substituted alkyl, optionally substituted aralkyl, aryl or heterocyclyl, orR.sup.2 and R.sup.3, together with the nitrogen atom to which they are bonded, can stand for an optionally substituted heterocyclic radical,R.sup.4 stands for hydrogen or alkyl andR.sup.5 stands for hydrogen, alkyl, halogenoalkyl or acyl, and their physiologically tolerated salts and their N-oxides have been found.Type: GrantFiled: April 20, 1989Date of Patent: January 29, 1991Assignee: Bayer AktiengesellschaftInventors: Hans Lindel, Werner Hallenbach, Friedrich Berschauer, Gernot Klotz, Heinrich A. Greife
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Patent number: 4960783Abstract: Method of promoting the yield and growth of animals which comprises administering to such animals a yield and growth promoting effective amount of a benzimidazole derivative of the formula ##STR1## in which R.sup.1 stands for hydrogen, hydroxyl, alkyl or halogenoalkyl,R.sup.2 stands for hydrogen, alkyl, halogen, CN or halogenalkyl,R.sup.3 stands for hydrogen, alkyl or acyl,R.sup.4 stands for hydrogen, alkyl or halogenoalkyl,R.sup.5 stands for alkyl or halogenoalkyl,R.sup.6 stands for alkyl or cycloalkyl, which is optionally substituted by halogen, cycloalkyl, OH, alkoxy, halogenoalkoxy or aryl, which can in turn be substituted by alkyl, halogen, CN or the radicals --COR.sup.7, --O--alkylene--COR.sup.7, --alkylene--R.sup.8 or --O-- alkylene--R.sup.8,R.sup.7 stands for hydroxyl, alkoxy or --NR.sup.9 R.sup.10,R.sup.8 stands for hydroxyl, alkoxy or --NR.sup.9 R.sup.10,R.sup.9 stands for hydrogen or alkyl andR.sup.10 stands for hydrogen or alkyl,or physiologically tolerated salts thereof.Type: GrantFiled: December 30, 1988Date of Patent: October 2, 1990Assignee: Bayer AktiengesellschaftInventors: Gerhard Bonse, Werner Hallenbach, Hans Lindel, Friedrich Berschauer
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Patent number: 4939262Type: GrantFiled: March 7, 1989Date of Patent: July 3, 1990Assignee: Bayer AktiengesellschaftInventors: Gerhard Bonse, Werner Hallenbach, Hans Lindel
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Patent number: 4927938Abstract: R.sup.2 is halogen,R.sup.3 is alkyl,R.sup.4 is C.sub.1-3 -alkyl,R.sup.5 is hydrogen or C.sub.1-2 -alkyl,R.sup.6 is C.sub.1-3 -alkyl, andHal is halogen.The process is new as are intermediates II, IV and V. The products are known intermediates.Type: GrantFiled: July 6, 1988Date of Patent: May 22, 1990Assignee: Bayer AktiengesellschaftInventors: Hans Lindel, Werner Hallenbach
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Patent number: 4920136Abstract: For promoting livestock production, the novel substituted pyridylethanolamines of the formula ##STR1## in which R.sup.1 represents CN, --COOR.sup.8 or --CONR.sup.9 R.sup.10,R.sup.2 represents optionally substituted alkyl,R.sup.3 represents hydrogen, alkyl or alkenyl,R.sup.4 represents hydrogen or optionally substituted alkyl or alkenyl, orR.sup.3 and R.sup.4 represent, together with the nitrogen atom to which they are bonded, an optionally substituted heterocyclic radical,R.sup.5 represents OH, acyloxy or alkoxy,R.sup.6 represents hydrogen or alkyl,R.sup.7 represents hydrogen, alkyl, cycloalkyl, substituted alkyl, optionally substituted aralkyl, aryl or heterocyclyl,R.sup.6 and R.sup.7 can, together with the nitrogen atom to which they are bonded, represent an optionally substituted heterocyclic radical,R.sup.8 represents alkyl, andR.sup.9 and R.sup.Type: GrantFiled: July 13, 1988Date of Patent: April 24, 1990Assignee: Bayer AktiengesellschaftInventors: Hans Lindel, Werner Hallenbach, Friedrich Berschauer
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Patent number: 4895950Abstract: Novel 5-halogeno-6-amino-nicotinic acid halides of the formula ##STR1## in which R represents hydrogen or alkyl,R.sup.1 represents hydrogen, alkyl or acyl orR and R.sup.1, together with the nitrogen atom to which they are bonded, represent an optionally substituted heterocyclic radical,R.sup.2 represents halogen andHal represents halogen,are prepared by halogenating the corresponding nicotinic acids. The Co Hal moiety is converted to CH.sub.3 by reaction withR.sup.3 OMgCR.sup.4 (COOR.sup.3).sub.2 (IV)in whichR.sup.3 represents C.sub.1-3 alkyl andR.sup.4 represents hydrogen or C.sub.1 -C.sub.2 -alkyl,and then hydrolyzing and decarboxylating the product.Type: GrantFiled: July 7, 1988Date of Patent: January 23, 1990Assignee: Bayer AktiengesellschaftInventors: Hans Lindel, Werner Hallenbach
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Patent number: 4880840Type: GrantFiled: June 30, 1987Date of Patent: November 14, 1989Assignee: Bayer AktiengesellschaftInventors: Hans Lindel, Axel Ingendoh, Friedrich Berschauer, Anno de Jong, Martin Scheer
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Patent number: 4863939Abstract: The growth of livestock is promoted by the new compounds of the formula ##STR1## in which R.sup.1 represents hydrogen, alkyl, halogen, halogenoalkyl, hydroxyl, cyano, alkoxycarbonyl, aminocarbonyl, mono- and dialkylaminocarbonyl, alkoxy, halogenoalkoxy, halogenoalkylthio or NHSO.sub.2 -alkyl,R.sup.2 represents hydrogen, hydroxyl, alkoxy or the --NR.sup.11 R.sup.12 radical,R.sup.3 represents the radicals mentioned in the case of R.sup.1R.sup.4 represents hydroxyl, acyloxy or alkoxy,R.sup.5 represents hydrogen or alkyl,R.sup.6 represents hydrogen or alkyl,R.sup.7 represents hydrogen or alkyl,R.sup.8 represents hydrogen or alkyl,X represents C.sub.1 -C.sub.10 -alkylene or a direct bond,Y represents oxygen or a direct bond,R.sup.9 represents hydrogen, C.sub.1 -C.sub.10 -alkyl which is optionally substituted by hydroxyl, alkoxy, acyloxy or the --NR.sup.13 R.sup.14 radical, or represents the COR.sup.15 radical or the O--Z--R.sup.16 radical,Z represents C.sub.1 -C.sub.10 -alkylene, C.sub.1 -C.sub.Type: GrantFiled: July 30, 1987Date of Patent: September 5, 1989Assignee: Bayer AktiengesellschaftInventors: Hans Lindel, Werner Hallenbach, Friedrich Berschauer, Anno de Jong, Martin Scheer
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Patent number: 4847291Abstract: Aryl ethanol-hydroxylamines of the formula ##STR1## in which Ar represents aryl or heteroaryl, each of which can optionally be substituted, andR represents alkyl, aryl, aralkyl, heteroaryl, heteroaralkyl or cycloalkyl, each of which can optionally be substituted,or physiologically tolerated salts thereof, exhibit animal growth-promoting properties. Intermediates therefor of the formula ##STR2## with the exception of phenyl and p-bromophenyl, are also new.Type: GrantFiled: July 11, 1986Date of Patent: July 11, 1989Assignee: Bayer AktiengesellschaftInventors: Axel Ingendoh, Hans Lindel, Friedrich Berschauer, Anno de Jong, Martin Scheer
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Patent number: 4847382Abstract: R.sup.2 represents hydrogen or halogen,R.sup.3 represents hydrogen or, together with R.sup.2, represents .dbd.0,R.sup.4 represents hydrogen or alkyl,R.sup.5 represents hydrogen, alkyl, halogenoalkyl or aryl,R.sup.7 represents alkyl,R.sup.8 represents alkyl, cyloalkyl, aralkyl, aryl or heterocyclyl, which can optionally be substituted,R.sup.9 represents acyl or hydrogen and Hal represents halogen.Compounds III are new. Compounds I are known as yield-promoting agents in animal feeds.Type: GrantFiled: February 29, 1988Date of Patent: July 11, 1989Assignee: Bayer AktiengesellschaftInventors: Werner Hallenbach, Hans Lindel