Patents by Inventor Hans Locher

Hans Locher has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8513231
    Abstract: The present invention relates to the use of compounds, in which the pharmacophores of quinolone and oxazolidinone are chemically linked together through a linker that is stable under physiological conditions, for the treatment of anthrax and other infections.
    Type: Grant
    Filed: August 28, 2012
    Date of Patent: August 20, 2013
    Assignee: Morphochem Aktiengesellschaft fü Kombinatorische Chemie
    Inventors: Christian Hubschwerlen, Jean-Luc Specklin, Daniel Baeschlin, Hans Locher, Christine Schmitt
  • Publication number: 20120322766
    Abstract: The present invention relates to the use of compounds, in which the pharmacophores of quinolone and oxazolidinone are chemically linked together through a linker that is stable under physiological conditions, for the treatment of anthrax and other infections.
    Type: Application
    Filed: August 28, 2012
    Publication date: December 20, 2012
    Applicant: Morphochem Aktiengesellschaft fuer Kombinatorische Chemie
    Inventors: Christian Hubschwerlen, Jean-Luc Specklin, Daniel Baeschlin, Hans Locher, Christine Schmitt
  • Patent number: 8268812
    Abstract: The present invention relates to the use of compounds, in which the pharmacophores of quinolone and oxazolidinone are chemically linked together through a linker that is stable under physiological conditions, for the treatment of anthrax and other infections.
    Type: Grant
    Filed: January 10, 2011
    Date of Patent: September 18, 2012
    Assignee: Morphochem Aktiengesellschaft fül Kombinatorische Chemie
    Inventors: Christian Hubschwerlen, Jean-Luc Specklin, Daniel Baeschlin, Hans Locher, Christine Schmitt
  • Publication number: 20120135961
    Abstract: The present invention relates to the use of compounds, in which the pharmacophores of quinolone and oxazolidinone are chemically linked together through a linker that is stable under physiological conditions, for the treatment of anthrax and other infections.
    Type: Application
    Filed: January 10, 2011
    Publication date: May 31, 2012
    Applicant: Morphochem Aktiengesellschaft Fur Kombinatorische Chemie
    Inventors: Christian Hubschwerlen, Jean-Luc Specklin, Daniel Baeschlin, Hans Locher, Christine Schmitt
  • Patent number: 8124623
    Abstract: The invention relates to novel chimeric antibiotics of formula I wherein R1 represents OH, OPO3H2 or OCOR5; R2 represents H, OH or OPO3H2; A represents N or CR6; R3 represents H or fluorine; R4 is H, (C1-C3) alkyl, or cycloalkyl; R5 is the residue of a naturally occurring amino acid, of the enantiomer of a naturally occurring amino acid or of dimethylaminoglycine; R6 represents H, alkoxy or halogen; and n is 0 or 1; and to salts (in particular pharmaceutically acceptable salts) of compounds of formula I. These chimeric compounds are useful in the manufacture of medicaments for the treatment of infections (e.g. bacterial infections).
    Type: Grant
    Filed: May 8, 2009
    Date of Patent: February 28, 2012
    Assignee: Actelion Pharmaceuticals Ltd.
    Inventors: Christian Hubschwerlen, Hans Locher, Philippe Panchaud, Jean-Luc Specklin
  • Publication number: 20090247578
    Abstract: The invention relates to novel chimeric antibiotics of formula I wherein R1 represents OH, OPO3H2 or OCOR5; R2 represents H, OH or OPO3H2; A represents N or CR6; R3 represents H or fluorine; R4 is H, (C1-C3) alkyl, or cycloalkyl; R5 is the residue of a naturally occurring amino acid, of the enantiomer of a naturally occurring amino acid or of dimethylaminoglycine; R6 represents H, alkoxy or halogen; and n is 0 or 1; and to salts (in particular pharmaceutically acceptable salts) of compounds of formula I. These chimeric compounds are useful in the manufacture of medicaments for the treatment of infections (e.g. bacterial infections).
    Type: Application
    Filed: May 8, 2009
    Publication date: October 1, 2009
    Applicant: Actelion Pharmaceuticals Ltd.
    Inventors: Christian HUBSCHWERLEN, Hans Locher, Philippe Panchaud, Jean-Luc Specklin
  • Publication number: 20070155714
    Abstract: The present invention relates to the use of compounds, in which the pharmacophores of quinolone and oxazolidinone are chemically linked together through a linker that is stable under physiological conditions, for the treatment of anthrax and other infections.
    Type: Application
    Filed: April 6, 2004
    Publication date: July 5, 2007
    Applicant: Morphochem Aktiengesellschaft Fur Kombinatorische Chemie
    Inventors: Christian Hubschwerlen, Jean-Luc Specklin, Daniel Baeschlin, Hans Locher, Christine Schmitt
  • Publication number: 20040132764
    Abstract: The present invention relates to the use of compounds, in which the pharmacophores of quinolone and oxazolidinone are chemically linked together through a linker that is stable under physiological conditions, for the treatment of bacterial infections in acidic environments (pH<7.0). The activity of these compounds is strongly increased at even slightly acidic conditions what makes them especially interesting for the treatment of infections in abscesses or inflamed tissues.
    Type: Application
    Filed: October 22, 2003
    Publication date: July 8, 2004
    Applicant: Morphochem Aktiengesellschaft fuer Kombinatorische Chemie
    Inventor: Hans Locher
  • Patent number: 5701640
    Abstract: A strap closure for straps of wrist watches comprises a magnetic closure and an automatic mechanical lock. The closure comprises two closure parts (1, 2) and at least one permanent magnet (16) and a yoke (9), which form parts of a magnetic circuit. Said magnetic circuit is disposed inside a shield (6) made of a ferromagnetic material and closed as far as possible on all sides. Between the magnetic circuit (9, 15, 16) and said shield or other closure parts there is no metallic contact whatsoever with elements of high permeability, the magnetic circuit is instead isolated from the shield or from other closure parts by air gaps (22, 23) and fastening elements (14) of a low permeability close to the value of air.
    Type: Grant
    Filed: November 6, 1995
    Date of Patent: December 30, 1997
    Inventor: Hans Locher
  • Patent number: 5377480
    Abstract: The cutting device proposed has cutting cells (3), located side by side, which collect the items to be cut. Each cell (3) contains a stationary element, which is designed to act as a support for the items to be cut and has a stop edge for the items, and a mobile element (4) which is designed to press the items together in the cell (3). During the cutting process, the mobile element is driven so that it remains substantially parallel to the support edge, and its motion during cutting is tangential to the items being cut. This tangential cutting action enables very considerable reductions to be made in energy consumption and noise generation. The cutting device is suitable for use in grass mowers, agricultural reaping and mowing machines and hedge clippers.
    Type: Grant
    Filed: August 18, 1993
    Date of Patent: January 3, 1995
    Inventor: Hans Locher
  • Patent number: 4016790
    Abstract: This invention relates to the art of quality control, more particularly to the regulation of electronically operated quality control equipment such as yarn cleaners, or the like so that the quality control equipment may be selectively adjusted to eliminate faults of a given magnitude only when they occur over an undesired period.
    Type: Grant
    Filed: April 23, 1976
    Date of Patent: April 12, 1977
    Assignee: Zellweger, Ltd.
    Inventors: Ernst Felix, Hans Locher
  • Patent number: 3971272
    Abstract: A method for regulating the operation of yarn clearers having error correcting means such as yarn cutters, and sensing means providing an electrical signal representative of the controlled quality. The method comprises the steps of: feeding the signal from the sensing means to two independent electrical circuit channels each having separate threshold switch means, the threshold switch means of one circuit responsive to signals corresponding to yarn faults of given magnitude. The threshold switch means of the other circuit responds to signals corresponding to faults of given duration. Thereafter, an independent control signal is obtained from each of said channels for initiating the operation of the cutters when a limiting value selected for each of said two channels is exceeded.
    Type: Grant
    Filed: July 8, 1974
    Date of Patent: July 27, 1976
    Assignee: Zellweger, Ltd.
    Inventors: Ernst Felix, Hans Locher
  • Patent number: 3958305
    Abstract: In order to compensate the combing periods in density fluctuation machine slivers, the density of each of a plurality of slivers is measured to detect the phase positions of the combing periods therein and then the relative positions of the respective slivers are adjusted to place the combing periods in each sliver out of phase with the combing periods in the other slivers before the slivers are combined. The adjustment of the phase position of the slivers is effected by varying the length of the path of the sliver between the combing machine and the point where the slivers are combined.
    Type: Grant
    Filed: October 30, 1973
    Date of Patent: May 25, 1976
    Assignee: Zellweger, Ltd.
    Inventors: Ernst Felix, Hans Locher