Abstract: The disclosure provides a method for treating a subject afflicted with a tumor derived from a small cell lung cancer (SCLC) having a high tumor mutational burden (TMB) status comprising administering to the subject a monotherapy comprising an anti-PD-1 antibody or a combination therapy comprising an anti-PD-1 antibody and an anti-CTLA-4 antibody. The present disclosure also provides a method for identifying a subject suitable for treatment with an anti-PD-1 antibody or a combination therapy comprising an anti-PD-1 antibody and an anti-CTLA-4 antibody comprising measuring a TMB status of a biological sample of the subject. A high TMB status identifies the patient as suitable for treatment with an anti-PD-1 antibody or antigen-binding portion thereof. The TMB status can be determined by sequencing nucleic acids in the tumor and identifying a genomic alteration, e.g., a somatic nonsynonymous mutation, in the sequenced nucleic acids.

Abstract: A tool system for machining includes a tool body that has a first end for connecting to a machine tool and a second end having an end face on which a seat for an interchangeable cutting insert is formed. The cutting insert has an underside formed as an abutment surface, a top side formed as a rake face, and an encircling side face formed as a flank, and a cutting edge is formed at a transition from the top side to the encircling side face. The cutting insert is arranged on the seat such that the top side extends perpendicularly to the longitudinal axis of the tool body and the cutting edge protrudes beyond the outer circumference of the end face of the tool body in a radial direction with respect to the longitudinal axis with two usable cutting corners and cutting-corner portions adjoining the latter on both sides.

Abstract: A tool system for machining includes a tool body that has a first end for connecting to a machine tool and a second end having an end face on which a seat for an interchangeable cutting insert is formed. The cutting insert has an underside formed as an abutment surface, a top side formed as a rake face, and an encircling side face formed as a flank, and a cutting edge is formed at a transition from the top side to the encircling side face. The cutting insert is arranged on the seat such that the top side extends perpendicularly to the longitudinal axis of the tool body and the cutting edge protrudes beyond the outer circumference of the end face of the tool body in a radial direction with respect to the longitudinal axis with two usable cutting corners and cutting-corner portions adjoining the latter on both sides.

Abstract: A tool system for machining includes a tool body that has a first end for connecting to a machine tool and a second end having an end face on which a seat for an interchangeable cutting insert is formed. The cutting insert has an underside formed as an abutment surface, a top side formed as a rake face, and an encircling side face formed as a flank, and a cutting edge is formed at a transition from the top side to the encircling side face. The cutting insert is arranged on the seat such that the top side extends perpendicularly to the longitudinal axis of the tool body and the cutting edge protrudes beyond the outer circumference of the end face of the tool body in a radial direction with respect to the longitudinal axis with two usable cutting corners and cutting-corner portions adjoining the latter on both sides.

Abstract: A tool system for machining includes a tool body that has a first end for connecting to a machine tool and a second end having an end face on which a seat for an interchangeable cutting insert is formed. The cutting insert has an underside formed as an abutment surface, a top side formed as a rake face, and an encircling side face formed as a flank, and a cutting edge is formed at a transition from the top side to the encircling side face. The cutting insert is arranged on the seat such that the top side extends perpendicularly to the longitudinal axis of the tool body and the cutting edge protrudes beyond the outer circumference of the end face of the tool body in a radial direction with respect to the longitudinal axis with two usable cutting corners and cutting-corner portions adjoining the latter on both sides.

Abstract: In one respect, there is provided an apparatus for neural stimulation. The apparatus may include an antenna, a plurality of electrodes, and a voltage supply generator. The antenna may be configured to receive, from an external source, radio frequency energy. The voltage supply generator configured to generate a voltage supply by at least ramping up a voltage of the radio frequency energy in successive increments, wherein the voltage supply drives a current to the plurality of electrodes during neural stimulation. Related methods and computer program products are also disclosed.

Abstract: In one respect, there is provided an apparatus for neural stimulation. The apparatus may include an antenna, a plurality of electrodes, and a voltage supply generator. The antenna may be configured to receive, from an external source, radio frequency energy. The voltage supply generator configured to generate a voltage supply by at least ramping up a voltage of the radio frequency energy in successive increments, wherein the voltage supply drives a current to the plurality of electrodes during neural stimulation. Related methods and computer program products are also disclosed.

Abstract: An electric field sensor includes one or more sensing electrodes connected to an integrated amplifier that bootstraps all parasitic capacitances at the sensor input to provide for a very high input impedance without the need for neutralization or other adjustments and calibration. The integrated amplifier for the electric field sensor further includes low-noise ESD/biasing structures to stabilize the DC-potential of the sensor with a minimum amount of added noise, leakage and parasitic capacitance.

Abstract: An electric field sensor includes one or more sensing electrodes connected to an integrated amplifier that bootstraps all parasitic capacitances at the sensor input to provide for a very high input impedance without the need for neutralization or other adjustments and calibration. The integrated amplifier for the electric field sensor further includes low-noise ESD/biasing structures to stabilize the DC-potential of the sensor with a minimum amount of added noise, leakage and parasitic capacitance.

Abstract: The indexable cutting insert for turning is formed with a plurality of main cutting edges. Adjacent main cutting edges, which enclose an angle with one another, are connected via a cutting corner. The cutting corner has two corner sections arranged symmetrically to a bisector of the angle. The corner sections, in the region of the angle bisector, have a depression with respect to the adjacent outer contours. Compared with conventional indexable inserts, the number of corner sections that can be used independently of one another is doubled.

Abstract: The indexable cutting insert for turning is formed with a plurality of main cutting edges. Adjacent main cutting edges, which enclose an angle with one another, are connected via a cutting corner. The cutting corner has two corner sections arranged symmetrically to a bisector of the angle. The corner sections, in the region of the angle bisector, have a depression with respect to the adjacent outer contours. Compared with conventional indexable inserts, the number of corner sections that can be used independently of one another is doubled.

Abstract: A packaging container for holding a plurality of articles. Packaging containers of this kind serve as transport and display means for a plurality of packed articles. These articles are sold directly from the packaging container. The empty packaging containers are usually destroyed, because their material and their structure do not permit repeated usage. The invention is concerned with providing a reusable packaging container of this kind. The described packaging container comprises a base part (11) and a stack top (12) which is releasably connected to the base part (11) and which can be collapsed and/or folded together, preferably in such a way that the collapsed or folded stack top (12) can be placed on the base part (11). As a result, empty packaging containers can be returned in a space-saving manner and, if required, they can be refilled, which means they are reusable.

Abstract: In a valve-controlled internal combustion engine with direct fuel injection and a swirling air charge, a combustion chamber is located in the piston and is configured as a toroidal part ending in a throat-like cylindrical part towards the piston top. A narrow, ring-shaped overflow passage leads from the toroidal part to the cylindrical part of the combustion chamber. The proposal is put forward that the thermal and fluid-mechanical parameters be improved by placing the axis of the combustion chamber between the tip of the injection nozzle and the cylinder axis, and by varying the width of the ring-shaped overflow passage. The narrowest part of said overflow passage lying in the area closest to the tip of the nozzle, and further, the top of the center part is unsymmetrical, with a minimum distance to the injection jets at upper dead center of the piston.

Abstract: The present invention relates to a double poppet valve comprising two independently movable valve heads cooperating with a valve seat located in a valve housing between an inlet duct and an outlet duct for a liquid product, and enclosing therebetween in the open position as well as in the closed position a leak control space adapted to be sealed in the open position of the valve to reduction of the distance between the two valve heads caused on opening of the valve by one of the valve heads being advanced so as to engage the other valve head at the end of a predetermined stroke, whereafter the two valve heads are forced into mutual sealing engagement by a spring force, the advancing valve head being affixed to a hollow actuating rod adapted to have supplied therethrough a cleaning liquid for said leak control space, a drain pipe communicating with said leak control space being provided for draining said cleaning liquid to the exterior.