Abstract: This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt, and/or hydrate, and/or cocrystal, and/or drug combination of the compound) that inhibit (e.g., antagonize) Stimulator of Interferon Genes (STING). Said chemical entities are useful, e.g., for treating a condition, disease or disorder in which increased (e.g., excessive) STING activation (e.g., STING signaling) contributes to the pathology and/or symptoms and/or progression of the condition, disease or disorder (e.g., cancer) in a subject (e.g., a human). This disclosure also features compositions containing the same as well as methods of using and making the same.

Abstract: The present invention generally relates to systems, methods and program products for use with Exchange-Traded Funds (“ETF”) holding one or more secured notes backed by one or more precious metals.

Abstract: A method for capturing at least particle compositions (21) in a monitoring region (14) that exhibit a temporally dynamic behaviour with an optical detection apparatus (12), and an optical detection apparatus (12) are described. In the method, during at least one measurement, optical transmission signals (22) are transmitted into the monitoring region (14) and transmission signals (22) that are reflected at particle targets (28) of any particle compositions (21) present in the monitoring region (14) are received as particle reflection signals (30). The presence of dynamic particle compositions (21) is concluded from the particle reflection signals (30). At least two measurements are performed with a temporal distance. A particle target density or a variable characterizing the particle target density is ascertained for at least one partial volume (48) of the monitoring region (14) from the particle reflection signals (30) of each measurement.

Abstract: This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt, and/or hydrate, and/or cocrystal, and/or drug combination of the compound) that inhibit (e.g., antagonize) Stimulator of Interferon Genes (STING). Said chemical entities are useful, e.g., for treating a condition, disease or disorder in which increased (e.g., excessive) STING activation (e.g., STING signaling) contributes to the pathology and/or symptoms and/or progression of the condition, disease or disorder (e.g., cancer) in a subject (e.g., a human). This disclosure also features compositions containing the same as well as methods of using and making the same.

Abstract: The invention relates to a method for managing information dealing with a medical test for assessing a predetermined medical condition by means of a distributed system (100) comprising a plurality of communication devices (210, 312, 322, 410), the method comprising obtaining by a user communication device (210) information on an access code provided in a test-kit for assessing a predetermined medical condition, the user communication device (210) being configured for receiving and displaying messages addressed to a unique identifier. Further, the method comprises providing instructions relating to analysis of the medical sample. A negative analysis result is communicated to the user communication device (210) of the user. In case of a positive analysis result, consultation by a medical entity is established. Further aspects relate to a user communication device, a computer program product, a central server and a medical test-kit for use with the proposed method.

Abstract: Example methods and systems are directed to generating knowledge graph entities from text. Natural language text is received as input and processed using named entity recognition (NER), part of speech (POS) recognition, and business object recognition (BOR). The outputs of the NER, POS, and BOR processes are combined to generate knowledge entity triples comprising two entities and a relationship between them. Keywords are extracted from the text using NER to generate a set of entities. A node in a knowledge graph is created for at least some of the entities. A POS tagger identifies verbs in the text, generating a set of verbs. Relational verbs (e.g., “talk to” or “communicated with”) are detected and used to create edges in the knowledge graph. The knowledge graph may be converted back to natural language text using a trained machine learning model.

Abstract: In a method for operating a household cooking appliance, a camera records a pixel-based image from a cooking chamber of the household cooking appliance. The image is evaluated with exclusion of brightness values of associated pixels thereof.

Abstract: Example methods and systems are directed to automatic data card generation for datasets. A data card is a summary that describes quantitative aspects of a dataset, qualitative aspects of a dataset, or both. The data samples and documentation of a dataset are analyzed automatically to determine a number of samples, a primary data type, a license, or any suitable combination thereof. Data formats for data and documentation of the dataset may be automatically recognized. Language of text data may be automatically recognized. The most frequent language for the text data may be identified as the primary language of the dataset. A data card may be created for the dataset. The data card may indicate the number of samples, the data formats used in the data set, the language of text data in the dataset, or any suitable combination thereof.

Abstract: An electrostatic discharge (ESD), protection device is provided. In accordance with the present disclosure, an ESD protection device is provided that includes a series connection of a first unit having strong snapback and low series capacitance and a second high-voltage unit that displays a relatively high holding/trigger voltage to ensure latch up and improper triggering of the ESD protection device while at the same time providing high-voltage operation with low capacitive loading.

Abstract: A procedure and apparatus for cementing and cleaning a reservoir liner 3 comprises installing a reservoir liner using a drill string 4 which extends only as far as the distal end of a cased part 2 of the well, then, using the drill string, displacing cement into the reservoir liner using completion fluid whereby, when the cement is in place in the annulus around the reservoir liner, the reservoir liner is already clean and filled with completion fluid. A ball valve 6 at the top of the reservoir liner 3 is then closed before the cased part 2 of the wellbore is cleaned, to avoid debris entering the reservoir liner.

Abstract: Some embodiments provide a non-transitory machine-readable medium that stores a program. The program receives a set of audio files. Each audio file in the set of audio files includes audio from an audio call. The program further truncates each audio file in the set of audio files to a defined call length. For each audio call in the set of audio calls, the program also receives a transcript of the audio call based on the audio file of the audio call. For each audio call in the set of audio calls, the program further uses the transcript of the audio call as input to a machine learning model for the machine learning model to predict a category from a plurality of categories that is associated with the audio call.

Abstract: A discharge protection semiconductor structure is provided that includes a substrate, a well positioned on the substrate, a first contact diffusion and a second contact diffusion, the first contact diffusion and the second contact diffusion positioned on the top side of the well, and a resistor positioned between the first contact diffusion and a second contact diffusion.

Abstract: A system for a motor vehicle may include a reservoir, a plurality of lubricant paths extending through the reservoir, a plurality of coolant paths extending through the reservoir, a plurality of delivery devices attached to the reservoir, and a plurality of coolers attached to the reservoir. The reservoir may include two sumps for lubricant. The reservoir may include (i) a plurality of reservoir lubricant inlet connections and a plurality of reservoir lubricant outlet connections through which the lubricant paths extend, (ii) a plurality of reservoir coolant inlet connections and a plurality of reservoir coolant outlet connections through which the coolant paths extend, (iii) a plurality of fluidic pump connections fluidically connected to the plurality of delivery devices, and (iv) a plurality of reservoir lubricant outlets, a plurality of reservoir lubricant inlets, a plurality of reservoir coolant outlets, and a plurality of reservoir coolant inlets fluidically connected to the coolers.

Abstract: In one aspect, compounds of Formula AA, or a pharmaceutically acceptable salt thereof, are featured: or a pharmaceutically acceptable salt thereof, wherein the variables shown in Formula A can be as defined anywhere herein.

Abstract: This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt, and/or hydrate, and/or cocrystal, and/or drug combination of the compound) having formula (I) that inhibit (e.g., antagonize) Stimulator of Interferon Genes (STING). Said chemical entities are useful, e.g., for treating a condition, disease or disorder in which increased (e.g., excessive) STING activation (e.g., STING signaling) contributes to the pathology and/or symptoms and/or progression of the condition, disease or disorder (e.g., cancer) in a subject (e.g., a human). This disclosure also features compositions containing the same as well as methods of using and making the same.

Abstract: A dual silicone no-lead (DSN), semiconductor device package is provided, the bond pad to the terminal includes an additional area in the second metallization layer, which is rectangularly shaped and extends from one side, e.g., the middle, of the terminal towards a location above the semiconductor device.

Abstract: In one aspect, compounds of Formula AA, or a pharmaceutically acceptable salt thereof, are featured or a pharmaceutically acceptable salt thereof, wherein the variables shown in Formula A can be as defined anywhere herein.

Abstract: A cell connector system is for connecting with at least one conductor tab of at least one single cell that is insertable into an electrical storage module having at least one frame device. The cell connector system includes a base contact profile with at least two end surfaces, a support surface, a transition surface, two opposing contact surfaces, and at least one lamella contact. The support surface can be placed on at least one frame device. At least one contact surface has a receiving recess with at least two retaining protrusions that receive the lamella contact. The lamella contact can establish a separable electrical connection to the conductor tab of the electrical single cell.

Abstract: An optical concentration measuring apparatus (1) that includes: a light emitter (3) on a main surface (20) of a substrate (2) that emits light from a light-emitting surface; a light receiver (4) on the main surface of the substrate that receives light at a light-receiving surface; and a light guide (5) that guides light emitted by the light emitter to the light receiver. The light guide includes a first reflector (51) and a second reflector (52) that are connected to the main surface of the substrate and are opposite each other in an overhead view of the main surface of the substrate. The second reflector includes two quadric surfaces. The first reflector includes a main reflective surface (53) that is a quadric surface and two secondary reflective surfaces (54) that are quadric surfaces and are integrally formed at portions of the main reflective surface.

Abstract: This disclosure features chemical entities of Formula I (e.g., a compound or a pharmaceutically acceptable salt, and/or hydrate, and/or cocrystal, and/or drug combination of the compound) that inhibit (e.g., antagonize) Stimulator of Interferon Genes (STING). Said chemical entities are useful, e.g., for treating a condition, disease or disorder in which increased (e.g., excessive) STING activation (e.g., STING signaling) contributes to the pathology and/or symptoms and/or progression of the condition, disease or disorder (e.g., cancer) in a subject (e.g., a human). This disclosure also features compositions containing the same as well as methods of using and making the same.