Patents by Inventor Hans Martin Schier

Hans Martin Schier has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Metal-binding cystein-free peptides for diagnostic and therapeutical purposes, methods for their production, and pharmaceuticals containing these compounds
    Patent number: 6291639
    Abstract: These invention relates to metal-complexing, cysteine-free peptides which may be coupled to an organ-specific probe directly or via a linker and are thus enriched as conjugates specifically in tumors, organs, tissues or centers of inflammation. The organ-specific probes used are, for example, antibodies or part-sequences of antibodies against tumor-associated antigens, e.g. the carcino-embryonal antigen (CEA, which are thus specifically enriched in tumors. The invention also relates to processes for producing the metal-complexing cysteine-free peptides and their conjugates. The present invention also relates to the use of the conjugates as components of a kit for in vivo diagnosis or in vivo therapy and radio-pharmaceuticals containing these conjugates together with radio-isotopes. The organ-specific conjugates are used to image tumors, organs or centers of inflammation.
    Type: Grant
    Filed: September 20, 1996
    Date of Patent: September 18, 2001
    Assignee: Institut Fue Diagnostikforschung GmbH
    Inventors: Jurgen Conrad, Ludger Dinkelborg, Sebastian Erber, Cornelius Frommel, Wolfgang Hohne, Wolfgang Kramp, Gabriele Kuttner, Reinhard Malin, Hans Martin Schier, Jens Schneider-Mergener, Renate Steinbrecher
  • Type S.sub.3 N.sub.2 chelators for radioactive isotopes, their metal complexes and their diagnostic and therapeutical use
    Patent number: 6143275
    Abstract: This invention relates to new bifunctional chelating agents with intermittent chalcogen atoms, pharmaceuticals containing these compounds, their use in radiodiagnostics and radiotherapy, and methods for the production of these compounds.The compound according to the invention has the general formula (I)M--Lwherein M represents a radionuclide of Tc or Re and L a ligand of the general formula (II)B--CO--CR.sup.1 R.sup.2 --A--CR.sup.3 R.sup.4 --CO--D (II)These new, bifunctional chelating agents with intermittent chalcogen atoms and their coupling products with compounds that accumulate specifically are suited for producing radiopharmaceuticals for diagnostic and therapeutic purposes.
    Type: Grant
    Filed: March 8, 1996
    Date of Patent: November 7, 2000
    Assignee: Institut fur Diagnostikforschung GmbH an der Freien Universitat Berlin
    Inventors: Christoph-Stephan Hilger, Ludger Dinkelborg, Wolfgang Kramp, Hans-Martin Schier
  • Chealators of type XN.sub.1 S.sub.1 X.sup.1 for radioactive isotopes, their metal complexes and their diagnostic and therapeutical uses
    Patent number: 5961954
    Abstract: This invention relates to new bifunctional chelating agents with intermittent chalcogen atoms, pharmaceuticals containing these compounds, their use in radiodiagnostics and radiotherapy, and methods for the production of these compounds.The compound according to the invention has the general formula (I)M--Lwhere M represents a radionuclide and L a ligand of the general formula (II).It was found, surprisingly, that these new, bifunctional chelating agents with intermittent chalcogen atoms and their coupling products with compounds that accumulate specifically are excellently suited for producing radiopharmaceuticals for diagnostic and therapeutic purposes.
    Type: Grant
    Filed: December 9, 1996
    Date of Patent: October 5, 1999
    Assignee: Institut fur Diagnostikforschung GmbH an der Freien Universitat Berlin
    Inventors: Christoph-Stephan Hilger, Ludger Dinkelborg, Wolfgang Kramp, Hans-Martin Schier