Patents by Inventor Hans O. Voigt

Hans O. Voigt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DNA-sequence encoding biosynthetic insulin precursors and process for preparing the insulin precursors and human insulin
    Patent number: 4916212
    Abstract: Human insulin precursors containing the peptide chain B(1-29)-A(1-21) of human insulin and derivatives thereof with a bridging chain connecting the carboxyl terminus of the B(1-29)-chain with the amino terminus of the A(1-21)-chain are prepared by culturing a yeast host transformed with a replicable expression vehicle capable of expressing a DNA-sequence encoding the insulin precursor. The bridging chain is preferably relatively short and contains preferably from 2 to 8 amino acid residues. The bridging chain must not contain two adjacent basic amino acid residues (Lys or Arg) and has one Lys or Arg connected to the amino terminus of the A(1-21)-chain. Human insulin is prepared from the insulin precursors by in vitro conversion.
    Type: Grant
    Filed: May 29, 1985
    Date of Patent: April 10, 1990
    Assignee: Novo Industri A/S
    Inventors: Jan Markussen, Niels Fiil, Mogens T. Hansen, Kjeld Norris, Gustav Ammerer, Lars Thim, Hans O. Voigt