Patents by Inventor Hans P. Kraemer
Hans P. Kraemer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5260425Abstract: The invention relates to new anthracycline derivatives having cytostatic activity and the general formula I, ##STR1## which can optionally also be in the form of an acid addition salt of physiologically acceptable inorganic or organic acids, where R.sup.1 is hydrogen or a hydroxyl group, R.sup.2 is hydrogen, a hydroxyl or a methoxy group, R.sup.3 is hydrogen or a hydroxyl group, R.sup.4 is hydrogen or a hydroxyl group, R.sup.5 hydrogen, a hydroxyl or a methoxycarbonyl group, R.sup.6 is CH.sub.2 CH.sub.3, COCH.sub.3, COCH.sub.2 OH, CHOHCH.sub.3 or CHOHCH.sub.2 OH and R.sup.Type: GrantFiled: June 2, 1989Date of Patent: November 9, 1993Assignee: Behringwerke AktiengesellschaftInventors: Peter Hermentin, Ernst Raab, Cenek Kolar, Manfred Gerken, Dieter Hoffmann, Hans P. Kraemer, Ulrich Stache
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Patent number: 5049549Abstract: 7-O-Glycosyl-rhodomycins which correspond to the general formula I below ##STR1## in which the radicals have the following meaning: R.sup.1 is a hydrogen atom or a hydroxyl group,R.sup.2 is a hydrogen atom or a C.sub.1 -C.sub.4 -alkyl group,R.sup.3 a hydroxyl group, an O-acyl protective group or the methyloxycarbonyl group,R.sup.4 is a hydrogen atom, an O-acyl protective group, an azido group, amino or trifluoroacetylamino group, a di-C.sub.1 -C.sub.4 -alkylamino group or cyanomethylamino group andR.sup.5 is an azido group, amino or trifluoroacetylamino group, a di-C.sub.1 -C.sub.4 -alkylamino group or cyanomethylamino group,where acyl protective group denotes an acetyl, mono-, di- or trihalogenoacetyl group with fluorine or chlorine as halogen or the p-nitrobenzoyl group, and a process for the preparation thereof and the use thereof as pharmaceuticals, are described.Type: GrantFiled: December 18, 1989Date of Patent: September 17, 1991Assignee: Behringwerke AktiengesellschaftInventors: Cenek Kolar, Hans P. Kraemer, Konrad Dehmel
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Patent number: 5037971Abstract: The present invention relates to anthracycline derivatives of the formula I ##STR1## in which at least one of the two substitutents R.sub.1 and R.sub.2 represents an N-oxidized sugar or an N-oxidized sugar combination, and a chemical process for the preparation of these compounds and their use as medicaments for the treatment of malignant tumors.Type: GrantFiled: January 8, 1990Date of Patent: August 6, 1991Assignee: Hoechst AktiengesellschaftInventors: Hans G. Berscheid, Hans-Wolfram Fehlhaber, Hans P. Kraemer, Harald Zilg
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Patent number: 4975531Abstract: The compounds of the formula I ##STR1## in which R.sub.1 to R.sub.3 denote, independently of one another, hydrogen or a (C.sub.1 -C.sub.18)-acyl group, and a process for the preparation thereof are described. These compounds have tumor-inhibiting properties.Type: GrantFiled: April 4, 1989Date of Patent: December 4, 1990Assignee: Behringwerke AktiengesellschaftInventors: Hans P. Kraemer, Lutz Robbel, Ludger M. Schwenen
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Patent number: 4965352Abstract: The invention relates to new anthracycline derivatives having cytostatic activity and the general formula I ##STR1## wherein R.sup.1 is a CH.sub.3 (CH.sub.2).sub.n group with n=0 to 3,R.sup.2 is a hydrogen atom or a methyl group,R.sup.3 is a hydrogen atom, a methyl group or an acyl protective group, andR.sup.4 is a hydrogen atom or an acyl protective group,and which are optionally in the form of a salt of an inorganic or organic acid, to a process for their preparation and to their use in pharmaceuticals.Type: GrantFiled: June 12, 1989Date of Patent: October 23, 1990Assignee: Behringwerke AktiengesellschaftInventors: Cenek Kolar, Michael Paal, Peter Hermentin, Hans P. Kraemer
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Patent number: 4948880Abstract: The invention relates to new anthracycline derivatives having cytostatic activity and the general formula I, which are optionally in the form of a salt of an inorganic or organic acid, ##STR1## in which the substituents have the following meaning: R.sup.1 is hydrogen or a hydroxyl group,R.sup.2 is hydrogen or a hydroxyl or a methoxy group,R.sup.3 is hydrogen or a hydroxyl group,R.sup.4 is hydrogen or a hydroxyl group,R.sup.5 is hydrogen, a hydroxyl or a methoxycarbonyl group, or a substituent of the general formula II, ##STR2## in which R.sup.8a has the meaning indicated for R.sup.8, or a substituent of the formula III, ##STR3## R.sup.6 is ethyl, methylcarbonyl, hydroxymethylcarbonyl, hydroxyalkyl or a dihydroxyalkyl,R.sup.7 is hydrogen or a substituent of the general formula IV, ##STR4## and R.sup.8 is hydrogen or a cyanomethyl group or a substituent of the general formula COR.sup.9 or CH.sub.2 R.sup.10, R.sup.9 being hydrogen, CH.sub.3, CF.sub.3 or CCl.sub.3, and R.sup.10 being C.sub.1 - to C.sub.Type: GrantFiled: December 4, 1987Date of Patent: August 14, 1990Assignee: Behringwerke AktiengesellschaftInventors: Peter Hermentin, Michael Paal, Hans P. Kraemer, Cenek Kolar, Dieter Hoffmann, Manfred Gerken, Hans G. Berscheid, Dirk Bottger
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Patent number: 4914191Abstract: The invention relates to new anthracycline derivatives having cytostatic activity and the general formula I ##STR1## in which the radicals R.sup.1 is hydrogen or a hydroxyl group, R.sup.2 is hydrogen or a hydroxyl group or a structure of the formula II, and R.sup.3 is a hydroxyl group or a structure of the formula II ##STR2## in which R.sup.4 is an aliphatic or aromatic acyl group, with the proviso that at least one of the radicals R.sup.2 and R.sup.3 has a structure of the formula II, which are optionally in the form of a salt of an inorganic or organic acid, as well as to the process for the preparation thereof, and to the use thereof in pharmaceuticals.Type: GrantFiled: July 7, 1988Date of Patent: April 3, 1990Assignee: Behringwerke AktiengesellschaftInventors: Peter Hermentin, Michael Paal, Cenek Kolar, Hans P. Kraemer, Dieter Hoffmann, Hans G. Berscheid, Dirk Bottger
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Patent number: 4849409Abstract: Streptazoline is reacted with naphthoquinones in a Diels-Alder reaction, and the adduct is then oxidized. The resulting compounds have cytotoxic activity, in particular against leukemia cells, and have an antimicrobial action and act against protozoa.Type: GrantFiled: May 12, 1987Date of Patent: July 18, 1989Assignee: Hoechst AktiengesellschaftInventors: Hans-Ullrich Hoppe, Susanne Grabley, Hartmut Voelskow, Merten Schlingmann, Hans P. Kraemer, Matthias Wiesner, Joachim Thiem
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Patent number: 4847299Abstract: The use of 15-deoxyspergualine for the preparation of a pharmaceutical for the therapy of degenerative diseases is claimed.Type: GrantFiled: July 31, 1987Date of Patent: July 11, 1989Assignee: Behringwerke AktiengesellschaftInventors: Gerhard Dickneite, Hans-Ulrich Schorlemmer, Hans P. Kraemer, Hans H. Sedlacek
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Patent number: 4801455Abstract: A pharmaceutical formulation for the parenteral, in particular intravenous, administration of sparingly soluble substances is obtained when the very finely ground substance, with a maximum particle diameter of 3 .mu.m, is dispersed in an oil phase which contains emulsifier, and this mixture is emulsified with water for injection, is rendered isotonic and is homogenized using a high-pressure homogenizer, so that the resultant product is a solid/liquid/liquid disperse system.Type: GrantFiled: July 9, 1987Date of Patent: January 31, 1989Assignee: Behringwerke AktiengesellschaftInventors: Paul H. List, Peter C. Schmidt, Klaus-Jurgen Steffens, Harald Perschbacher, Hans P. Kraemer, Hans H. Sedlacek
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Patent number: 4795808Abstract: The present invention relates to anthracycline derivatives and a process for their preparation. The compounds are distinguished by a high cytostatic activity and can therefore be used as medicaments with an anti-tumor action.Type: GrantFiled: November 24, 1986Date of Patent: January 3, 1989Assignee: Hoechst AktiengesellschaftInventors: Hans G. Berscheid, Dirk Bottger, Hans P. Kraemer
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Patent number: 4789665Abstract: The present invention relates to new anthracyclines corresponding to the general formula I below: ##STR1## in which R' and R", which may be identical or different, denote a hydrogen atom (and in this case R' is different from R") or the group --(CH.sub.2).sub.n --R.sub.1 --(CH.sub.2).sub.m --R.sub.2 where n is between 1 and 6,m is between 0 and 4 (with the proviso, of course, that if m=0, R.sub.2 is nonexistent)R.sub.1 denotes one of the following groups: ##STR2## (in this case, m=0) ##STR3## (in this case m=0) where R.sub.3 and R.sub.4, which may be identical or different, denote a hydrogen atom or a substituted or unsubstituted alkyl group)--C.tbd.N (in this case m=0)--S----O--(with the proviso that m is other than 0) ##STR4## (m=0 and R.sub.3 R.sub.4 have the same meaning as above) and R.sub.2 denotes (in the case where m is other than 0) a hydrogen atom or alkyl or alkoxy groups or ##STR5## (R.sub.3 and R.sub.4 having the same meaning as above).Type: GrantFiled: December 15, 1986Date of Patent: December 6, 1988Assignees: Laboratoires Hoechst S. A., Behringwerke AktiengesellschaftInventors: Jean-Pierre Gesson, Martine Mondon, Jean-Claude Jacquesy, Hans P. Kraemer
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Patent number: 4762648Abstract: The present invention relates to a novel mono-functional and bis-functional anthraquinone-(oxy-2,3-oxido-propanes) and to a process for their preparation. The compounds according to the invention are useful as intermediates in the preparation of drugs possessing a .beta.-receptor blocker action and as crosslinking agents in the preparation of polymers, and moreover exhibit cytostatic activity.Type: GrantFiled: August 29, 1984Date of Patent: August 9, 1988Assignee: Hoechst AktiengesellschaftInventors: Ulrich Stache, Hans P. Kraemer, Hans-Harald Sedlacek
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Patent number: 4730069Abstract: Compounds of the general formulae I and II ##STR1## in which R.sup.1 and R.sup.2 independently of one another represent H--(CH.sub.2).sub.a --(O--(CH.sub.2).sub.b).sub.c --O, where a=0 to 4, b=1 to 4 and c=1 to 7, an alkoxy or arylalkoxy group with 1 to 20 carbon atoms, an alkane- or aralkanesulfonyloxy group with 1 to 7 carbon atoms or a tetrahydropyranyloxy radical, orR.sup.1 and R.sup.2 together represent an oxygen atom bonded in an ether-like manner or an acetal or ketal radical ##STR2## where R.sup.3 and R.sup.4 independently of one another represent a hydrogen atom, an alkyl group with 1 to 20 carbon atoms of a phenyl group,A.sup.1 and A.sup.2 are identical and represent a hydroxyl group, chloride, bromide, iodide, nitrate, acetate, trifluoroacetate, trifluorosulfonate or perchlorate, orA.sup.1 represents sulfate or carbonate ion and A.sup.2 represents H.sub.2 O, orA.sup.1 A.sup.Type: GrantFiled: August 30, 1985Date of Patent: March 8, 1988Assignee: Behringwerke AktiengesellschaftInventors: Cenek Kolar, Hans P. Kraemer, Konrad Dehmel
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Patent number: 4713371Abstract: The present invention relates to the micro-organism Streptomyces purpurascens (DSM 2658), its mutants and variants, a process for the preparation of anthracycline derivatives by fermentation of these cultures and to the anthracycline derivatives themselves. The new compounds are distinguished by antibacterial activity and, in addition, they act against various types of tumors.Type: GrantFiled: February 3, 1986Date of Patent: December 15, 1987Assignee: Hoechst AktiengesellschaftInventors: Werner Aretz, Hans G. Berscheid, Gerhard Huber, Hans-Wolfram Fehlhaber, Hans P. Kraemer, Hans-Harald Sedlacek, Bimal N. Ganguli, Ratan S. Sood, Julia Gandhi, Gauknapalli C. Reddy