Patents by Inventor Hans P. Wessel

Hans P. Wessel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Sulfonamide derivatives
    Patent number: 8158655
    Abstract: The invention is concerned with the novel sulfonamide derivatives of formula (I) wherein A, R1 to R2?, X and Y are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit chymase and can be used as medicaments.
    Type: Grant
    Filed: January 8, 2008
    Date of Patent: April 17, 2012
    Assignee: Hoffmann-La Roche Inc.
    Inventors: David Banner, Harald Mauser, Rudolf E. Minder, Hans P. Wessel
  • FBPase inhibitors for diabetes
    Patent number: 7868030
    Abstract: Compounds of formula as well as pharmaceutically acceptable salts and esters thereof, wherein R1 to R3 have the significance given in the application and which can be used in the form of pharmaceutical compositions.
    Type: Grant
    Filed: May 30, 2007
    Date of Patent: January 11, 2011
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Marcel Gubler, Wolfgang Haap, Paul Hebeisen, Eric A. Kitas, Bernd Kuhn, Rudolf E. Minder, Brigitte Schott, Hans P. Wessel
  • NOVEL SULFONAMIDE DERIVATIVES
    Publication number: 20080167348
    Abstract: The invention is concerned with the novel sulfonamide derivatives of formula (I) wherein A, R1 to R2?, X and Y are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit chymase and can be used as medicaments.
    Type: Application
    Filed: January 8, 2008
    Publication date: July 10, 2008
    Inventors: David Banner, Harald Mauser, Rudolf E. Minder, Hans P. Wessel
  • New FBPase inhibitors for diabetes
    Publication number: 20070281979
    Abstract: Compounds of formula as well as pharmaceutically acceptable salts and esters thereof, wherein R1 to R3 have the significance given in the application and which can be used in the form of pharmaceutical compositions.
    Type: Application
    Filed: May 30, 2007
    Publication date: December 6, 2007
    Inventors: Marcel Gubler, Wolfgang Haap, Paul Hebeisen, Eric A. Kitas, Bernd Kuhn, Rudolf E. Minder, Brigitte Schott, Hans P. Wessel
  • DPP IV inhibitors
    Publication number: 20030130281
    Abstract: The present invention relates to compounds of formula (I) 1
    Type: Application
    Filed: October 14, 2002
    Publication date: July 10, 2003
    Inventors: Markus Boehringer, Daniel Hunziker, Holger Kuehne, Bernd M. Loeffler, Ramakanth Sarabu, Hans P. Wessel
  • N-(4- carbamimidoyl-phenyl) -glycine derivatives
    Publication number: 20010001799
    Abstract: The invention is concerned with novel N-(4-carbamimidoyl-phenyl)-glycine derivatives of the formula: 1
    Type: Application
    Filed: January 12, 2001
    Publication date: May 24, 2001
    Inventors: Jean Ackermann, Leo Alig, Alexander Chucholowski, Katrin Groebke, Kurt Hilpert, Holger Kuehne, Ulrike Obst, Lutz Weber, Hans P. Wessel
  • Guanidine derivatives
    Patent number: 5595999
    Abstract: Compounds of the formula ##STR1## wherein L, M, R, T and X are set forth in the description, as well as hydrates or solvates thereof, which inhibit thrombin-induced platelet aggregation and clotting of fibrinogen in plasma, are described. The compounds of formula I are prepared by amidination or, depending on whether L is NH or O, by amide formation or esterification.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: January 21, 1997
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Jean Ackermann, David Banner, Klaus Gubernator, Paul Hadvary, Kurt Hilpert, Klaus M uller, Ludvik Labler, G erard Schmid, Thomas B. Tschopp, Hans P. Wessel, Beat Wirz
  • Guanidine derivatives
    Patent number: 5583133
    Abstract: Compounds of the formula ##STR1## wherein L, M, R, T and X are set forth in the description, as well as hydrates or solvates thereof, which inhibit thrombin-induced platelet aggregation and clotting of fibrinogen in plasma, are described. The compounds of formula I are prepared by amidination or, depending on whether L is NH or O, by amide formation or esterification.
    Type: Grant
    Filed: August 4, 1995
    Date of Patent: December 10, 1996
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Jean Ackermann, David Banner, Klaus Gubernator, Paul Hadvary, Kurt Hilpert, Klaus M uller, Ludvik Labler, G erard Schmid, Thomas B. Tschopp, Hans P. Wessel, Beat Wirz
  • Guanidine derivatives
    Patent number: 5532232
    Abstract: Compounds of the formula ##STR1## wherein L, M, R, T and X are set forth in the description, as well as hydrates or solvates thereof, which inhibit thrombin-induced platelet aggregation and clotting of fibrinogen in plasma, are described. The compounds of formula I are prepared by amidination or, depending on whether L is NH or O, by amide formation or esterification.
    Type: Grant
    Filed: November 22, 1994
    Date of Patent: July 2, 1996
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Jean Ackermann, David Banner, Klaus Gubernator, Paul Hadvary, Kurt Hilpert, Klaus Muller, Ludvik Labler, Gerard Schmid, Thomas B. Tschopp, Hans P. Wessel, Beat Wirz
  • Sulfuric acid esters of sugar alcohols
    Patent number: 5521160
    Abstract: The present invention is concerned with novel sulfuric acid esters of sugar alcohols and sugar alcohol-like compounds of the formula ##STR1## Also described are methods for the treatment and/or prophylaxis of arteriosclerotic changes in the vascular wall as well as a process for the manufacture of the compounds of formula I and their salts.
    Type: Grant
    Filed: January 4, 1995
    Date of Patent: May 28, 1996
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Alexander Chucholowski, Jurgen Fingerle, Niggi Iberg, Hans P. Marki, Rita Muller, Michael Pech, Marianne Rouge, Gerard Schmid, Thomas Tschopp, Hans P. Wessel
  • Sulfated oligosaccharides
    Patent number: 5447919
    Abstract: The use of compounds of the formula ##STR1## wherein R is hydrogen or a residue --SO.sub.3 M; M is a cation; and R' and R" are hydrogen or an .alpha.-glycosidically linked sulfated mono- or disaccharide residue; and at least one --SO.sub.3 M group is present per monosaccharide unit,as pharmaceutical compositions for the prevention and/or treatment of arteriosclerotic disorders and for the prevention of restenosis after invasive vascular surgery and after organ transplants.
    Type: Grant
    Filed: March 17, 1994
    Date of Patent: September 5, 1995
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Markus Hosang, Niggi Iberg, Thomas B. Tschopp, Hans P. Wessel
  • Guanidine derivatives
    Patent number: 5393760
    Abstract: Compounds of the formula ##STR1## wherein L, M, R, T and X are set forth in the description, as well as hydrates or solvates thereof, which inhibit thrombin-induced platelet aggregation and clotting of fibrinogen in plasma, are described. The compounds of formula I are prepared by amidination or, depending on whether L is NH or O, by amide formation or esterification.
    Type: Grant
    Filed: June 15, 1993
    Date of Patent: February 28, 1995
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Jean Ackermann, David Banner, Klaus Gubernator, Paul Hadvary, Kurt Hilpert, Klaus Muller, Ludvik Labler, Gerard Schmid, Thomas B. Tschopp, Hans P. Wessel, Beat Wirz
  • Sulfated O-polysaccharide-trehaloses
    Patent number: 5298616
    Abstract: Sulphated O-Polysaccharide-trehaloses which can be used as medicaments, especially for the treatment of arteriosclerotic disorders.
    Type: Grant
    Filed: September 20, 1991
    Date of Patent: March 29, 1994
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Markus Hosang, Niggi Iberg, Michel Trumtel, Thomas B. Tschopp, Hans P. Wessel
  • Guanidine derivatives compositions and use
    Patent number: 5260307
    Abstract: Compounds of the formula ##STR1## wherein L, M, R, T and X are set forth in the description, as well as hydrates or solvates thereof, which inhibit thrombin-induced platelet aggregation and clotting of fibrinogen in plasma, are described. The compounds of formula I are prepared by amidination or, depending on whether L is NH or O, by amide formation or esterification.
    Type: Grant
    Filed: June 24, 1991
    Date of Patent: November 9, 1993
    Assignee: Hofmann-La Roche Inc.
    Inventors: Jean Ackermann, David Banner, Klaus Gubernator, Paul Hadvary, Kurt Hilpert, Klaus Muller, Ludvik Labler, Gerard Schmid, Thomas B. Tschopp, Hans P. Wessel, Beat Wirz
  • Sulfated oligosaccharides
    Patent number: 4885361
    Abstract: Novel compounds with anti-proliferative and mucosaprotective activity are obtained by sulfating trestatins.
    Type: Grant
    Filed: July 20, 1988
    Date of Patent: December 5, 1989
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Hans P. Wessel