Patents by Inventor Hans Parge

Hans Parge has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PIN1 peptidyl-prolyl isomerase polypeptides, their crystal structures, and use thereof for drug design
    Publication number: 20040171019
    Abstract: Polypeptides containing the PIN1 peptidyl-prolyl isomerase domain but not containing the PIN1 WW domain are described. Also described are crystal structures of these polypeptides, including the crystal structure of a PIN1 PPIase:ligand complex. The structure coordinate data derived from these crystals provides a three-dimensional description of the substrate-binding site of PIN1 peptidyl-prolyl isomerase useful in drug discovery and design for the identification and design of modulators of PIN1 peptidyl-prolyl isomerase activity.
    Type: Application
    Filed: December 19, 2003
    Publication date: September 2, 2004
    Applicant: Agouron Pharmaceuticals, Inc.
    Inventors: David Matthews, Eleanor Dagostino, Rose Ann Ferre, Smita Gaur, Chuangxing Guo, Xinjun Hou, Stephen Margosiak, Barbara Mroczkowski, Grace Reiko Nakayama, Hans Parge, Jeff Zhu
  • Catalytic domains of the human hepatocyte growth factor receptor tyrosine kinase, and materials and methods for identification of inhibitors thereof
    Publication number: 20040009568
    Abstract: The identification, isolation, purification, and characterization of the catalytic domain of the human hepatocyte growth factor receptor kinase (hHGFR) are described. A crystal structure of the hHGFR kinase domain is reported herein. This structure provides a three-dimensional description of the binding site of the hHGFR for structure-based design of small molecule inhibitors thereof as therapeutic agents. The kinase domain of human HGFR and its associated crystal structure is described for use in the discovery, identification and characeterization of modulators of human HGFR.
    Type: Application
    Filed: March 25, 2002
    Publication date: January 15, 2004
    Inventors: Barbara Mroczkowski, Michael Hickey, Michele Ann McTigue, Brion William Murray, Hans Parge, Jay Sarup, Jeff Zhu