Patents by Inventor Hans-Peter Buchstaller

Hans-Peter Buchstaller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9751861
    Abstract: Compounds of the formula (I) in which R, R1 and R3 have the meanings indicated in claim 1, are inhibitors of pyruvate dehydrogenase kinase (PDHK), and can be employed, inter alia, for the treatment of diseases such as cancer.
    Type: Grant
    Filed: November 19, 2014
    Date of Patent: September 5, 2017
    Assignee: Merck Patent GmbH
    Inventor: Hans-Peter Buchstaller
  • Patent number: 9732094
    Abstract: The invention relates to novel compounds of the formula (I) which can be used for the inhibition of serine-threonine protein kinases and for the sensitization of cancer cells to anticancer agents and/or ionizing radiation.
    Type: Grant
    Filed: May 8, 2014
    Date of Patent: August 15, 2017
    Assignee: Merck Patent GmbH
    Inventors: Thomas Fuchss, Ulrich Emde, Hans-Peter Buchstaller, Werner Mederski
  • Patent number: 9718826
    Abstract: Compounds of the formula I in which R1 and R2 have the meanings indicated in Claim 1, are inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.
    Type: Grant
    Filed: December 3, 2014
    Date of Patent: August 1, 2017
    Assignee: MERCK PATENT GMBH
    Inventors: Hans-Peter Buchstaller, Dieter Dorsch
  • Publication number: 20170073347
    Abstract: Compounds of the formula I in which W, X and Y have the meanings indicated in Claim 1, are inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.
    Type: Application
    Filed: April 16, 2015
    Publication date: March 16, 2017
    Applicant: Merck Patent GmbH
    Inventors: Hans-Peter BUCHSTALLER, Dieter DORSCH
  • Publication number: 20170002010
    Abstract: Compounds of the formula I in which R1 and R2 have the meanings indicated in Claim 1, are inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.
    Type: Application
    Filed: December 3, 2014
    Publication date: January 5, 2017
    Applicant: MERCK PATENT GMBH
    Inventors: Hans-Peter BUCHSTALLER, Dieter DORSCH
  • Publication number: 20160318876
    Abstract: Compounds of the formula I in which R1, X and n have the meanings indicated in Claim 1, are inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.
    Type: Application
    Filed: May 30, 2014
    Publication date: November 3, 2016
    Applicant: Marck Patent GmbH
    Inventors: Hans-Peter BUCHSTALLER, Dieter DORSCH, Christina ESDAR, Birgitta LEUTHNER
  • Publication number: 20160311798
    Abstract: Compounds of the formula (I) in which R, R1 and R3 have the meanings indicated in claim 1, are inhibitors of pyruvate dehydrogenase kinase (PDHK), and can be employed, inter alia, for the treatment of diseases such as cancer.
    Type: Application
    Filed: November 19, 2014
    Publication date: October 27, 2016
    Applicant: MERCK PATENT GMBH
    Inventor: Hans-Peter BUCHSTALLER
  • Patent number: 9388142
    Abstract: Compounds of the formula I in which R1, R2, R3, X1, X2 and Y have the meanings indicated in Claim 1, are inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.
    Type: Grant
    Filed: August 27, 2013
    Date of Patent: July 12, 2016
    Assignee: MERCK PATENT GMBH
    Inventors: Dieter Dorsch, Hans-Peter Buchstaller
  • Publication number: 20160184310
    Abstract: Compounds of the formula I in which R1-R3 and Z have the meanings indicated in Claim 1, are inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.
    Type: Application
    Filed: July 10, 2014
    Publication date: June 30, 2016
    Applicant: MERCK PATENT GMBH
    Inventors: Dieter DORSCH, Hans-Peter BUCHSTALLER
  • Publication number: 20160184285
    Abstract: Compounds of the formula I in which R1-R3 have the meanings indicated in Claim 1, are inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.
    Type: Application
    Filed: July 9, 2014
    Publication date: June 30, 2016
    Applicant: MERCK PATENT GMBH
    Inventors: Hans-Peter BUCHSTALLER, Dieter DORSCH
  • Patent number: 9376433
    Abstract: Compounds of the formula I in which R1, X, Y and n have the meanings indicated in claim 1, are inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.
    Type: Grant
    Filed: July 12, 2013
    Date of Patent: June 28, 2016
    Assignee: Merck Patent GmbH
    Inventors: Dieter Dorsch, Hans-Peter Buchstaller
  • Patent number: 9339503
    Abstract: Compounds of the formula I in which U, V and W have the meanings indicated in Claim 1, are inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.
    Type: Grant
    Filed: January 14, 2013
    Date of Patent: May 17, 2016
    Assignee: MERCK PATENT GMBH
    Inventors: Hans-Peter Buchstaller, Christina Esdar, Birgitta Leuthner
  • Publication number: 20160083401
    Abstract: The invention relates to novel compounds of the formula (I) which can be used for the inhibition of serine-threonine protein kinases and for the sensitisation of cancer cells to anticancer agents and/or ionising radiation.
    Type: Application
    Filed: May 8, 2014
    Publication date: March 24, 2016
    Applicant: Merck Patent GmbH
    Inventors: Thomas FUCHSS, Ulrich EMDE, Hans-Peter BUCHSTALLER, Werner MEDERSKI
  • Patent number: 9238651
    Abstract: 1H-Pyrrolo[2,3-b]pyridine compounds are inhibitors of cell proliferation/cell vitality and can be employed for the treatment of tumours.
    Type: Grant
    Filed: August 13, 2014
    Date of Patent: January 19, 2016
    Assignee: MERCK PATENT GMBH
    Inventors: Timo Heinrich, Margarita Wucherer-Plietker, Hans-Peter Buchstaller
  • Patent number: 9187469
    Abstract: The invention relates to compounds of the formula (I) in which R1, L and m have the meaning indicated in the claims, and/or physiologically acceptable salts, tautomers and stereoisomers thereof, including mixtures thereof in all ratios. The compounds of the formula (I) can be used for the inhibition of serine/threonine protein kinases and for the sensitization of cancer cells to anticancer agents and/or ionizing radiation. The invention also relates to the use of the compounds of the formula (I) in the prophylaxis, therapy or progress control of cancer, tumors, metastases or angiogenesis disorders, in combination with radiotherapy and/or an anticancer agent. The invention furthermore relates to a process for the preparation of the compounds of the formula (I) by reaction of compounds of the formulae (II) and (III) and optionally conversion of a base or acid of the compounds of the formula (I) into a salt thereof.
    Type: Grant
    Filed: October 30, 2012
    Date of Patent: November 17, 2015
    Assignee: Merck Patent GmbH
    Inventors: Werner Mederski, Thomas Fuchss, Ulrich Emde, Hans-Peter Buchstaller
  • Patent number: 9174995
    Abstract: Compounds of the formula I in which X, R1 and Y have the meanings indicated in claim 1, are inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.
    Type: Grant
    Filed: April 6, 2013
    Date of Patent: November 3, 2015
    Assignee: MERCK PATENT GMBH
    Inventors: Dieter Dorsch, Hans-Peter Buchstaller
  • Patent number: 9120805
    Abstract: Compounds of the formula I in which R1, X and Y have the meanings indicated in Claim 1, are inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.
    Type: Grant
    Filed: March 19, 2013
    Date of Patent: September 1, 2015
    Assignee: Merck Patent GmbH
    Inventors: Dieter Dorsch, Hans-Peter Buchstaller, Gerard Moinet, Ansgar Wegener
  • Publication number: 20150239850
    Abstract: Compounds of the formula I in which R1, R2, R3, X1, X2 and Y have the meanings indicated in claim 1, are inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.
    Type: Application
    Filed: August 27, 2013
    Publication date: August 27, 2015
    Applicant: MERCK PATENT GMBH
    Inventors: Dieter Dorsch, Hans-Peter Buchstaller
  • Publication number: 20150210686
    Abstract: Compounds of the formula I in which R1, X, Y and n have the meanings indicated in Claim 1, are inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.
    Type: Application
    Filed: July 12, 2013
    Publication date: July 30, 2015
    Applicant: MERCK PATENT GMBH
    Inventors: Dieter Dorsch, Hans-Peter Buchstaller
  • Publication number: 20150133453
    Abstract: Compounds of the formula I in which X, R1 and Y have the meanings indicated in Claim 1, are inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.
    Type: Application
    Filed: April 6, 2013
    Publication date: May 14, 2015
    Applicant: Merck Patent GmbH
    Inventors: Dieter Dorsch, Hans-Peter Buchstaller