Patents by Inventor Hans-Peter Buchstaller

Hans-Peter Buchstaller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PIPERIDINYL DERIVATIVES
    Publication number: 20190135753
    Abstract: Compounds of the formula I in which X, Y, R1 and R2 have the meanings indicated in claim 1, are inhibitors of pyruvate dehydrogenase kinase (PDHK), and can be employed, inter alia, for the treatment of diseases such as cancer.
    Type: Application
    Filed: April 25, 2017
    Publication date: May 9, 2019
    Applicant: MERCK PATENT GMBH
    Inventor: Hans-Peter BUCHSTALLER
  • 1,4-DICARBONYL-PIPERIDYL DERIVATIVES
    Publication number: 20190092751
    Abstract: Compounds of the formula I in which Z, W, Q, R and Y have the meanings indicated in claim 1, are inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.
    Type: Application
    Filed: October 7, 2016
    Publication date: March 28, 2019
    Applicant: Merck Patent GmbH
    Inventors: Hans-Peter BUCHSTALLER, Dieter DORSCH
  • BICYCLIC HETEROCYCLIC DERIVATIVES
    Publication number: 20190010151
    Abstract: Compounds of the formula Ia or of the formula Ib in which X, Y, R1 and R2 have the meanings indicated in claim 1, are inhibitors of pyruvate dehydrogenase kinase (PDHK), and can be employed, inter alia, for the treatment of diseases such as cancer.
    Type: Application
    Filed: June 30, 2016
    Publication date: January 10, 2019
    Applicant: Merck Patent GmbH
    Inventor: Hans-Peter BUCHSTALLER
  • Arylquinazolines
    Patent number: 10172859
    Abstract: The invention relates to novel compounds of the formula (I) which can be used for the inhibition of serine-threonine protein kinases and for the sensitization of cancer cells to anticancer agents and/or ionizing radiation.
    Type: Grant
    Filed: June 26, 2017
    Date of Patent: January 8, 2019
    Assignee: Merck Patent GmbH
    Inventors: Thomas Fuchss, Ulrich Emde, Hans-Peter Buchstaller, Werner Mederski
  • Oxoquinazolinyl-butanamide derivatives
    Patent number: 9901577
    Abstract: Compounds of the formula I in which R1-R3 and Z have the meanings indicated in Claim 1, are inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.
    Type: Grant
    Filed: July 10, 2014
    Date of Patent: February 27, 2018
    Assignee: MERCK PATENT GMBH
    Inventors: Dieter Dorsch, Hans-Peter Buchstaller
  • Heterocyclyl-butanamide derivatives
    Patent number: 9809598
    Abstract: Compounds of the formula I in which W, X and Y have the meanings indicated in Claim 1, are inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.
    Type: Grant
    Filed: April 16, 2015
    Date of Patent: November 7, 2017
    Assignee: MERCK PATENT GMBH
    Inventors: Hans-Peter Buchstaller, Dieter Dorsch
  • ARYLQUINAZOLINES
    Publication number: 20170290836
    Abstract: The invention relates to novel compounds of the formula (I) which can be used for the inhibition of serine-threonine protein kinases and for the sensitisation of cancer cells to anticancer agents and/or ionising radiation.
    Type: Application
    Filed: June 26, 2017
    Publication date: October 12, 2017
    Inventors: Thomas Fuchss, Ulrich Emde, Hans-Peter Buchstaller, Werner Mederski
  • Piperidine urea derivatives
    Patent number: 9770446
    Abstract: Compounds of the formula I in which R1-R3 have the meanings indicated in Claim 1, are inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.
    Type: Grant
    Filed: July 9, 2014
    Date of Patent: September 26, 2017
    Assignee: MERCK PATENT GMBH
    Inventors: Hans-Peter Buchstaller, Dieter Dorsch
  • Phthalazine derivatives
    Patent number: 9751842
    Abstract: Compounds of the formula I in which R1, X and n have the meanings indicated in Claim 1, are inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.
    Type: Grant
    Filed: May 30, 2014
    Date of Patent: September 5, 2017
    Assignee: Marck Patent GmbH
    Inventors: Hans-Peter Buchstaller, Dieter Dorsch, Christina Esdar, Birgitta Leuthner
  • N1-(3,3,3-trifluoro-2-hydroxo-2-methylpropionyl)-piperidine derivatives as inhibitors of pyruvate dehydrogenase kinase
    Patent number: 9751861
    Abstract: Compounds of the formula (I) in which R, R1 and R3 have the meanings indicated in claim 1, are inhibitors of pyruvate dehydrogenase kinase (PDHK), and can be employed, inter alia, for the treatment of diseases such as cancer.
    Type: Grant
    Filed: November 19, 2014
    Date of Patent: September 5, 2017
    Assignee: Merck Patent GmbH
    Inventor: Hans-Peter Buchstaller
  • Arylquinazolines
    Patent number: 9732094
    Abstract: The invention relates to novel compounds of the formula (I) which can be used for the inhibition of serine-threonine protein kinases and for the sensitization of cancer cells to anticancer agents and/or ionizing radiation.
    Type: Grant
    Filed: May 8, 2014
    Date of Patent: August 15, 2017
    Assignee: Merck Patent GmbH
    Inventors: Thomas Fuchss, Ulrich Emde, Hans-Peter Buchstaller, Werner Mederski
  • Imidazopyrazinone derivatives
    Patent number: 9718826
    Abstract: Compounds of the formula I in which R1 and R2 have the meanings indicated in Claim 1, are inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.
    Type: Grant
    Filed: December 3, 2014
    Date of Patent: August 1, 2017
    Assignee: MERCK PATENT GMBH
    Inventors: Hans-Peter Buchstaller, Dieter Dorsch
  • HETEROCYCLYL-BUTANAMIDE DERIVATIVES
    Publication number: 20170073347
    Abstract: Compounds of the formula I in which W, X and Y have the meanings indicated in Claim 1, are inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.
    Type: Application
    Filed: April 16, 2015
    Publication date: March 16, 2017
    Applicant: Merck Patent GmbH
    Inventors: Hans-Peter BUCHSTALLER, Dieter DORSCH
  • IMIDAZOPYRAZINONE DERIVATIVES
    Publication number: 20170002010
    Abstract: Compounds of the formula I in which R1 and R2 have the meanings indicated in Claim 1, are inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.
    Type: Application
    Filed: December 3, 2014
    Publication date: January 5, 2017
    Applicant: MERCK PATENT GMBH
    Inventors: Hans-Peter BUCHSTALLER, Dieter DORSCH
  • PHTHALAZINE DERIVATIVES
    Publication number: 20160318876
    Abstract: Compounds of the formula I in which R1, X and n have the meanings indicated in Claim 1, are inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.
    Type: Application
    Filed: May 30, 2014
    Publication date: November 3, 2016
    Applicant: Marck Patent GmbH
    Inventors: Hans-Peter BUCHSTALLER, Dieter DORSCH, Christina ESDAR, Birgitta LEUTHNER
  • N1-(3,3,3-TRIFLUORO-2-HYDROXO-2-METHYLPROPIONYL)-PIPERIDINE DERIVATIVES AS INHIBITORS OF PYRUVATE DEHYDROGENASE KINASE
    Publication number: 20160311798
    Abstract: Compounds of the formula (I) in which R, R1 and R3 have the meanings indicated in claim 1, are inhibitors of pyruvate dehydrogenase kinase (PDHK), and can be employed, inter alia, for the treatment of diseases such as cancer.
    Type: Application
    Filed: November 19, 2014
    Publication date: October 27, 2016
    Applicant: MERCK PATENT GMBH
    Inventor: Hans-Peter BUCHSTALLER
  • Quinazolinone derivatives as PARP inhibitors
    Patent number: 9388142
    Abstract: Compounds of the formula I in which R1, R2, R3, X1, X2 and Y have the meanings indicated in Claim 1, are inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.
    Type: Grant
    Filed: August 27, 2013
    Date of Patent: July 12, 2016
    Assignee: MERCK PATENT GMBH
    Inventors: Dieter Dorsch, Hans-Peter Buchstaller
  • PIPERIDINE UREA DERIVATIVES
    Publication number: 20160184285
    Abstract: Compounds of the formula I in which R1-R3 have the meanings indicated in Claim 1, are inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.
    Type: Application
    Filed: July 9, 2014
    Publication date: June 30, 2016
    Applicant: MERCK PATENT GMBH
    Inventors: Hans-Peter BUCHSTALLER, Dieter DORSCH
  • OXOQUINAZOLINYL-BUTANAMIDE DERIVATIVES
    Publication number: 20160184310
    Abstract: Compounds of the formula I in which R1-R3 and Z have the meanings indicated in Claim 1, are inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.
    Type: Application
    Filed: July 10, 2014
    Publication date: June 30, 2016
    Applicant: MERCK PATENT GMBH
    Inventors: Dieter DORSCH, Hans-Peter BUCHSTALLER
  • (AZA-)isoquinolinone derivatives
    Patent number: 9376433
    Abstract: Compounds of the formula I in which R1, X, Y and n have the meanings indicated in claim 1, are inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.
    Type: Grant
    Filed: July 12, 2013
    Date of Patent: June 28, 2016
    Assignee: Merck Patent GmbH
    Inventors: Dieter Dorsch, Hans-Peter Buchstaller