Patents by Inventor Hans-Peter Hohmann
Hans-Peter Hohmann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11466303Abstract: The present invention is related to production of a sterol mix in a modified yeast cell, wherein the amount of zymosterol present in said mix is dramatically reduced or abolished via modification of sterol acyltransferase activity within said yeast. The modified yeast cell can be used for production of vitamin D3 or derivatives and/or metabolites thereof.Type: GrantFiled: December 20, 2016Date of Patent: October 11, 2022Assignee: DSM IP ASSETS B.V.Inventors: Hans-Peter Hohmann, Regina Leber, Martin Lehmann, Corinna Odar, Barbara Petschacher, Harald Pichler, Birgit Ploier
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Publication number: 20210180103Abstract: The present invention is related to production of a sterol mix in a modified yeast cell, wherein the amount of zymosterol present in said mix is dramatically reduced or abolished via modification of sterol acyltransferase activity within said yeast. The modified yeast cell can be used for production of vitamin D3 or derivatives and/or metabolites thereof.Type: ApplicationFiled: December 20, 2016Publication date: June 17, 2021Inventors: Hans-Peter HOHMANN, Regina LEBER, Martin LEHMANN, Corinna ODAR, Barbara PETSCHACHER, Harald PICHLER, Birgit PLOIER
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Patent number: 10676764Abstract: The present invention relates to a novel and inventive process for the production of sorbitol from D-sucrose.Type: GrantFiled: July 14, 2016Date of Patent: June 9, 2020Assignee: DSM IP ASSETS B.V.Inventors: Mae Joanne Aguila, Hans-Peter Hohmann, Laurent Lefort, Jonathan Alan Medlock, Guenter Pappenberger
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Patent number: 10633684Abstract: The present invention provides an improved biotechnological production of riboflavin (also referred herein as vitamin B2) through modification in the operon containing the riboflavin biosynthetic genes (rib operon), in particular modifications of/in the leader sequences (rib leader) upstream of the corresponding riboflavin biosynthetic genes (rib operon). Furthermore, the present invention relates to genetically engineered microorganisms carrying said modified sequences, processes to generate said modified sequences/microorganisms and the use thereof for production of riboflavin.Type: GrantFiled: November 9, 2009Date of Patent: April 28, 2020Assignee: DSM IP ASSETS B.V.Inventors: Martin Lehmann, Hans-Peter Hohmann, Dietmar Laudert, Michael Hans
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Patent number: 10252962Abstract: The present invention relates to a new process for the production of D-sorbitol.Type: GrantFiled: July 14, 2016Date of Patent: April 9, 2019Assignee: DSM IP ASSETS B.V.Inventors: Mae Joanne Aguila, Hans Peter Hohmann, Laurent Lefort, Jonathan Alan Medlock, Guenter Pappenberger
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Publication number: 20180201558Abstract: The present invention relates to a new process for the production of D-sorbitol.Type: ApplicationFiled: July 14, 2016Publication date: July 19, 2018Inventors: Mae Joanne AGUILA, Hans Peter HOHMANN, Laurent LEFORT, Jonathan Alan MEDLOCK, Guenter PAPPENBERGER
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Publication number: 20180201959Abstract: The present invention relates to a novel and inventive process for the production of sorbitol from D-sucrose.Type: ApplicationFiled: July 14, 2016Publication date: July 19, 2018Inventors: Mae Joanne AGUILA, Hans-Peter HOHMANN, Laurent LEFORT, Jonathan Alan MEDLOCK, Guenter PAPPENBERGER
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Patent number: 9624521Abstract: This invention relates to the production of 7-dehydrocholesterol, 25-hydroxy-7-dehydrocholesterol, and 25-hydroxy ergosterol in yeast such as Saccharomyces cerevisiae. It also relates to various enzymes catalyzing the reduction of the double bond at position 24 of lanosterol, dimethyl zymosterol, methyl zymosterol, zymosterol, cholesta-7, 24-dienol, or cholesta-5,7,24-trienol; or the hydroxylation at position 25 of ergosterol, 7-dehydrocholesterol, cholesta-8-enol, and cholesta-7-enol. It also relates to various nucleic acids encoding cholesterol C25-hydroxylases and sterol ?24-reductases and their use to produce and hydroxylate 7-dehydrocholesterol or ergosterol. It also relates to the yeast strains so produced, and methods of making these sterols that include the steps of cultivaton a transformed yeast cell, and harvesting the resulting sterol(s).Type: GrantFiled: November 24, 2010Date of Patent: April 18, 2017Assignee: DSM IP ASSETS B.V.Inventors: Hans-Peter Hohmann, Martin Lehmann, Muriel Merkamm, Denis Pompon
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Patent number: 9315784Abstract: The present invention relates to a improved process for the biotechnological production of compounds for which ribose-5-phosphate, ribulose-5-phosphate or xylulose-5-phosphate is biosynthetic precursor like riboflavin (vitamin B2), FAD, FMN, pyridoxal phosphate (vitamin B6), guanosine, GMP, adenosine, AMP. The invention further pertains to the generation of the organism producing those compounds. It furthermore relates to the generation of mutated transketolases that allow normal growth on glucose but reduced growth on gluconate when introduced into the production strains and to polynucleotides encoding them.Type: GrantFiled: July 26, 2012Date of Patent: April 19, 2016Assignee: DSM IP ASSETS B.V.Inventors: Michael Hans, Dietmar Laudert, Hans-Peter Hohmann, Martin Lehmann
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Patent number: 8722360Abstract: The present invention is directed to novel genes mediating the carbon catabolite repression (CCR) of gluconeogenic genes. Furthermore, the polypeptides encoded by said genes as well as the use of said genes in a process for the production of a target fermentation product is provided. Processes for generating such microorganisms are also provided by the present invention. The invention is also related to a genetically engineered microorganism and its use for the production of a target fermentation product, wherein the gluconeogenic genes are relieved from CCR within said microorganism.Type: GrantFiled: December 22, 2005Date of Patent: May 13, 2014Assignees: DSM IP Assets B.V., Institute National de la Recherche AgronomiqueInventors: Stephane Aymerich, Hans-Peter Hohmann, Uwe Sauer
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Publication number: 20130189731Abstract: The present invention relates to a improved process for the biotechnological production of compounds for which ribose-5-phosphate, ribulose-5-phosphate or xylulose-5-phosphate is biosynthetic precursor like riboflavin (vitamin B2), FAD, FMN, pyridoxal phosphate (vitamin B6), guanosine, GMP, adenosine, AMP. The invention further pertains to the generation of the organism producing those compounds. It furthermore relates to the generation of mutated transketolases that allow normal growth on glucose but reduced growth on gluconate when introduced into the production strains and to polynucleotides encoding them.Type: ApplicationFiled: July 26, 2012Publication date: July 25, 2013Applicant: DSM IP Assets B.V.Inventors: Michael Hans, Dietmar Laudert, Hans-Peter Hohmann, Martin Lehmann
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Publication number: 20120231495Abstract: This invention relates to the production of 7-dehydrocholesterol, 25-hydroxy-7-dehydrocholesterol, and 25-hydroxy ergosterol in yeast such as Saccharomyces cerevisiae. It also related to various enzymes catalyzing the reduction of the double bond at position 24 of lanosterol, dimethyl zymosterol, methyl zymosterol, zymosterol, cholesta-7, 24-dienol, or cholesta-5,7,24-trienol; or the hydroxylation at position 25 of ergosterol, 7-dehydrocholesterol, cholesta-8-enol, and cholesta-7-enol. It also relates to various nucleic acids encoding cholesterol C25-hydroxylases and sterol ?24-reductases and their use to produce and hydroxylate 7-dehydrocholesterol or ergosterol. It also relates to the yeast strains so produced, and methods of making these sterols comprising the steps of cultivation a transformed yeast cell, and harvesting the resulting sterol(s).Type: ApplicationFiled: November 24, 2010Publication date: September 13, 2012Inventors: Hans-Peter Hohmann, Martin Lehmann, Muriel Merkamm, Denis Pompon
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Patent number: 8257944Abstract: The present invention relates to a improved process for the biotechnological production of compounds for which ribose-5-phosphate, ribulose-5-phosphate or xylulose-5-phosphate is biosynthetic precursor like riboflavin (vitamin B2), FAD, FMN, pyridoxal phosphate (vitamin B6), guanosine, GMP, adenosine, AMP. The invention further pertains to the generation of the organism producing those compounds. It furthermore relates to the generation of mutated transketolases that allow normal growth on glucose but reduced growth on gluconate when introduced into the production strains and to polynucleotides encoding them.Type: GrantFiled: October 25, 2006Date of Patent: September 4, 2012Assignee: DSM IP Assets B.V.Inventors: Michael Hans, Dietmar Laudert, Hans-Peter Hohmann, Martin Lehmann
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Publication number: 20110312025Abstract: The present invention provides an improved biotechnological production of riboflavin (also referred herein as vitamin B2) through modification in the operon containing the riboflavin biosynthetic genes (rib operon), in particular modifications of/in the leader sequences (rib leader) upstream of the corresponding riboflavin biosynthetic genes (rib operon). Furthermore, the present invention relates to genetically engineered microorganisms carrying said modified sequences, processes to generate said modified sequences/microorganisms and the use thereof for production of riboflavin.Type: ApplicationFiled: November 9, 2009Publication date: December 22, 2011Inventors: Martin Lehmann, Hans-Peter Hohmann, Dietmar Laudert, Michael Hans
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Patent number: 7695949Abstract: The present invention provides a process for producing a target fermentation product. This process includes providing a fermentation medium containing a recombinantly-produced microorganism that over-produces a fermentation product and contains a mutation which causes auxotrophic growth of the microorganism wherein the auxotrophy within the microorganism does not compromise the ability of the microorganism to produce the fermentation product. The medium is then supplied in excess with all substrates required for production of the fermentation product and in growth limiting amounts with a substrate complementing the auxotrophy. Host cells, vectors, and polynucleotide sequences used in the process are also provided. The polynucleotide sequences of the present invention include sequences derived from the biotin operon of B. subtilis and in particular the bioFDB gene cassette.Type: GrantFiled: October 8, 2003Date of Patent: April 13, 2010Assignee: DSM IP Assets B.V.Inventors: Hans-Peter Hohmann, Nigel John Mouncey, Heinrich Winfred Schlieker, Jeffrey W. Stebbins
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Publication number: 20080311617Abstract: The present invention relates to a improved process for the biotechnological production of compounds for which ribose-5-phosphate, ribulose-5-phosphate or xylulose-5-phosphate is biosynthetic precursor like riboflavin (vitamin B2), FAD, FMN, pyridoxal phosphate (vitamin B6), guanosine, GMP, adenosine, AMP. The invention further pertains to the generation of the organism producing those compounds. It furthermore relates to the generation of mutated transketolases that allow normal growth on glucose but reduced growth on gluconate when introduced into the production strains and to polynucleotides encoding them.Type: ApplicationFiled: October 25, 2006Publication date: December 18, 2008Inventors: Michael Hans, Dietmar Laudert, Hans-Peter Hohmann, Martin Lehmann
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Publication number: 20080311620Abstract: The present invention is directed to novel genes mediating the carbon catabolite repression (CCR) of gluconeogenic genes. Furthermore, the polypeptides encoded by said genes as well as the use of said genes in a process for the production of a target fermentation product is provided. Processes for generating such microorganisms are also provided by the present invention. The invention is also related to a genetically engineered microorganism and its use for the production of a target fermentation product, wherein the gluconeogenic genes are relieved from CCR within said microorganism.Type: ApplicationFiled: December 22, 2005Publication date: December 18, 2008Applicants: DSM IP ASSETS B.V., INSTITUTE NATIONAL DE LA RECHERCHE AGRONOMIQUEInventors: Stephane Aymerich, Hans-Peter Hohmann, Uwe Sauer
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Patent number: 7344855Abstract: A process for the preparation of a target fermentation product comprising cultivation of an aerobic microorganism to produce such product, wherein in the microorganism the efficiency of the respiratory chain is increased, transformed and novel nucleotide sequences.Type: GrantFiled: February 20, 2003Date of Patent: March 18, 2008Assignee: DSM IP Assets B.V.Inventors: Hans-Peter Hohmann, Nigel John Mouncey, Uwe Sauer, Nicola Zamboni
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Publication number: 20050124030Abstract: A process for the preparation of a target fermentation product comprising cultivation of an aerobic microorganism to produce such product, wherein in the microorganism the effi-ciency of the respiratory chain is increased, transformed microorganisms and novel nuc-leotide sequences.Type: ApplicationFiled: February 20, 2003Publication date: June 9, 2005Inventors: Hans-Peter Hohmann, Nigel Mouncey, Uwe Sauer, Nicola Zamboni
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Publication number: 20040063171Abstract: The present invention provides a process for producing a target fermentation product. This process includes providing a fermentation medium containing a recombinantly-produced microorganism that over-produces a fermentation product and contains a mutation which causes auxotrophic growth of the microorganism wherein the auxotrophy within the microorganism does not compromise the ability of the microorganism to produce the fermentation product. The medium is then supplied in excess with all substrates required for production of the fermentation product and in growth limiting amounts with a substrate complementing the auxotrophy. Host cells, vectors, and polynucleotide sequences used in the process are also provided.Type: ApplicationFiled: October 8, 2003Publication date: April 1, 2004Applicant: ROCHE VITAMINS, INC.Inventors: Hans-Peter Hohmann, Nigel John Mouncey, Heinrich Winfred Schlieker, Jeffrey W. Stebbins