Patents by Inventor Hans-Peter Kley

Hans-Peter Kley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyrazolone-derivatives and their use as PDE-4 inhibitors
    Patent number: 9340522
    Abstract: The compounds of Formula (I), are novel effective inhibitors of the type 4 phosphodiesterase.
    Type: Grant
    Filed: November 15, 2013
    Date of Patent: May 17, 2016
    Assignee: TAKEDA GMBH
    Inventors: Imre Schlemminger, Beate Schmidt, Dieter Flockerzi, Hermann Tenor, Christof Zitt, Armin Hatzelmann, Degenhard Marx, Clemens Braun, Raimund Kuelzer, Anke Heuser, Hans-Peter Kley, Geert Jan Sterk
  • Pyrazolone derivatives as PDE4 inhibitors
    Patent number: 9090597
    Abstract: The compound 1-(2-{4-[3-(3,4-dimethoxyphenyl)-4,4-dimethyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl]piperidin-1-yl}-2-oxoethyl)pyrrolidine-2,5-dione is a novel effective inhibitor of the type 4 phosphodiesterase useful in the treatment of psoriasis or atopic dermatitis.
    Type: Grant
    Filed: August 29, 2014
    Date of Patent: July 28, 2015
    Assignee: Takeda GmbH
    Inventors: Beate Schmidt, Christian Scheufler, Jürgen Volz, Martin Feth, Rolf-Peter Hummel, Armin Hatzelmann, Christof Zitt, Andrea Wohlsen, Degenhard Marx, Hans-Peter Kley, Deborah Ockert, Anke Heuser, Johannes A. M. Christiaans, Geert Jan Sterk, Wiro M. P. B. Menge
  • PYRAZOLONE DERIVATIVES AS PDE4 INHIBITORS
    Publication number: 20140378509
    Abstract: The compound 1-(2-{4-[3-(3,4-dimethoxyphenyl)-4,4-dimethyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl]piperidin-1-yl}-2-oxoethyl)pyrrolidine-2,5-dione is a novel effective inhibitor of the type 4 phosphodiesterase useful in the treatment of psoriasis or atopic dermatitis.
    Type: Application
    Filed: August 29, 2014
    Publication date: December 25, 2014
    Inventors: Beate SCHMIDT, Christian SCHEUFLER, Jürgen VOLZ, Martin FETH, Rolf-Peter HUMMEL, Armin HATZELMANN, Christof ZITT, Andrea WOHLSEN, Degenhard MARX, Hans-Peter KLEY, Deborah OCKERT, Anke HEUSER, Johannes A.M. CHRISTIAANS, Geert Jan STERK, Wiro M.P.B. MENGE
  • Pyrazolone derivatives as PDE4 inhibitors
    Patent number: 8865745
    Abstract: The compound 1-(2-{4-[3-(3,4-dimethoxyphenyl)-4,4-dimethyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl]piperidin-1-yl}-2-oxoethyl)pyrrolidine-2,5-dione is a novel effective inhibitor of the type 4 phosphodiesterase.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: October 21, 2014
    Assignee: Takeda GmbH
    Inventors: Beate Schmidt, Christian Scheufler, Juergen Volz, Martin Feth, Rolf-Peter Hummel, Armin Hatzelmann, Christof Zitt, Andrea Wohlsen, Degenhard Marx, Hans-Peter Kley, Deborah Ockert, Anke Heuser, Johannes A. M. Christiaans, Geert Jan Sterk, Wiro M. P. B. Menge
  • NOVEL PYRAZOLONE-DERIVATIVES AND THEIR USE AS PDE-4 INHIBITORS
    Publication number: 20140073672
    Abstract: The compounds of Formula (I), are novel effective inhibitors of the type 4 phosphodiesterase.
    Type: Application
    Filed: November 15, 2013
    Publication date: March 13, 2014
    Applicant: TAKEDA GMBH
    Inventors: Imre SCHLEMMINGER, Beate SCHMIDT, Dieter FLOCKERZI, Hermann TENOR, Christof ZITT, Armin HATZELMANN, Degenhard MARX, Clemens BRAUN, Raimund KUELZER, Anke HEUSER, Hans-Peter KLEY, Geert Jan STERK
  • Pyrazolone-derivatives and their use as PDE-4 inhibitors
    Patent number: 8609848
    Abstract: The compounds of Formula (I), are novel effective inhibitors of the type 4 phosphodiesterase.
    Type: Grant
    Filed: November 12, 2009
    Date of Patent: December 17, 2013
    Assignee: Takeda GmbH
    Inventors: Imre Schlemminger, Beate Schmidt, Dieter Flockerzi, Hermann Tenor, Christof Zitt, Armin Hatzelmann, Degenhard Marx, Clemens Braun, Raimund Külzer, Anke Heuser, Hans-Peter Kley, Geert Jan Sterk
  • Roflumilast for the treatment of diabetes mellitus type 2
    Patent number: 8541456
    Abstract: The application relates to specific combinations of Roflumilast and/or Roflumilast N-Oxide and a PPAR-agonist, as well as their use in the treatment of diabetes mellitus type 2.
    Type: Grant
    Filed: July 11, 2011
    Date of Patent: September 24, 2013
    Assignee: Takeda GmbH
    Inventors: Hans-Peter Kley, Guido Hanauer, Daniela Hauser, Beate Schmidt, Dirk Bredenbröker, Wilhelm Wurst, Jörg Kemkowski
  • PYRAZOLONE DERIVATIVES AS PDE4 INHIBITORS
    Publication number: 20130012544
    Abstract: The compound 1-(2-{4-[3-(3,4-dimethoxyphenyl)-4,4-dimethyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl]piperidin-1-yl}-2-oxoethyl)pyrrolidine-2,5-dione is a novel effective inhibitor of the type 4 phosphodiesterase.
    Type: Application
    Filed: September 14, 2012
    Publication date: January 10, 2013
    Applicant: NYCOMED GMBH
    Inventors: Beate SCHMIDT, Christian SCHEUFLER, Jürgen VOLZ, Martin FETH, Rolf-Peter HUMMEL, Armin HATZELMANN, Christof ZITT, Andrea WOHLSEN, Degenhard MARX, Hans-Peter KLEY, Deborah OCKERT, Anke HEUSSR, Johannes A.M. CHRISTIAANS, Geert Jan STERK, Wiro M.P.B. MENGE
  • Pyrazolone derivatives as PDE4 inhibitors
    Patent number: 8304436
    Abstract: The compounds of a certain formula 1, in which R1, R7, R8, R9 and n have the meanings as given in the description, are novel effective inhibitors of the type 4 phosphodiesterase.
    Type: Grant
    Filed: May 14, 2008
    Date of Patent: November 6, 2012
    Assignee: Nycomed GmbH
    Inventors: Beate Schmidt, Christian Scheufler, Juergen Volz, Martin Feth, Rolf-Peter Hummel, Armin Hatzelmann, Christof Zitt, Andrea Wohlsen, Degenhard Marx, Hans-Peter Kley, Deborah Ockert, Anke Heuser, Johannes A. M. Christiaans, Geert Jan Sterk, Wiro M. P. B. Menge
  • Combination of a NSAID and a PDE-4 inhibitor
    Patent number: 8242146
    Abstract: The invention relates to the combined use of a PDE4 inhibitor and a conventional NSAID in the treatment of an inflammatory disease and/or an inflammation-associated disorder while minimizing gastrointestinal side effects, such as gastric erosions and ulcer, which are frequently associated with the use of conventional NSAIDs. A preferred PDE 4 inhibitor for this combination is roflumilast or a derivative thereof. A preferred conventional NSAID for this combination is diclofenac or a derivative thereof.
    Type: Grant
    Filed: December 20, 2007
    Date of Patent: August 14, 2012
    Assignee: Nycomed GmbH
    Inventors: Thomas Klein, Hans-Peter Kley
  • Triazolophthalazines
    Patent number: 8106047
    Abstract: The compounds of formula (I) in which R1, R2 and R3 have the meanings as given in the description are novel effective PDE2 inhibitors.
    Type: Grant
    Filed: January 4, 2006
    Date of Patent: January 31, 2012
    Assignee: NYCOMED GmbH
    Inventors: Beate Schmidt, Steffen Weinbrenner, Dieter Flockerzi, Raimund Külzer, Hermann Tenor, Hans-Peter Kley
  • ROFLUMILAST FOR THE TREATMENT OF DIABETES MELLITUS
    Publication number: 20110269750
    Abstract: The application relates to specific combinations of Roflumilast and/or Roflumilast N-Oxide and a PPAR-agonist, as well as their use in the treatment of diabetes mellitus type 2.
    Type: Application
    Filed: July 11, 2011
    Publication date: November 3, 2011
    Applicant: NYCOMED GMBH
    Inventors: Hans-Peter KLEY, Guido HANAUER, Daniela HAUSER, Beate SCHMIDT, Dirk BREDENBRÖKER, Wilhelm WURST, Jörg KEMKOWSKI
  • Roflumilast for the treatment of diabetes mellitus
    Patent number: 8017633
    Abstract: The invention relates to the use of Roflumilast and/or Roflumilast N-Oxide for the treatment of diabetes mellitus and accompanying disorders thereof. The invention additionally relates to combinations of Roflumilast and/or Roflumilast N-Oxide with other active agents for the treatment of diabetes mellitus.
    Type: Grant
    Filed: March 3, 2006
    Date of Patent: September 13, 2011
    Assignee: Nycomed GmbH
    Inventors: Hans-Peter Kley, Guido Hanauer, Daniela Hauser, Beate Schmidt, Dirk Bredenbroeker, Wilhelm Wurst, Joerg Kemkowski
  • NOVEL PYRAZOLONE-DERIVATIVES AND THEIR USE AS PDE-4 INHIBITORS
    Publication number: 20110218201
    Abstract: The compounds of Formula (I), are novel effective inhibitors of the type 4 phosphodiesterase.
    Type: Application
    Filed: November 12, 2009
    Publication date: September 8, 2011
    Applicant: NYCOMED GMBH
    Inventors: Imre Schlemminger, Beate Schmidt, Dieter Flockerzi, Hermann Tenor, Christof Zitt, Armin Hatzelmann, Degenhard Marx, Clemens Braun, Raimund Külzer, Anke Heuser, Hans-Peter Kley, Geert Jan Sterk
  • Triazolophthalazines
    Publication number: 20110136803
    Abstract: The compounds of formula (I) in which R1, R2 and R3 have the meanings as given in the description are novel effective PDE2 inhibitors.
    Type: Application
    Filed: November 5, 2009
    Publication date: June 9, 2011
    Applicant: NYCOMED GMBH
    Inventors: Beate Schmidt, Steffen Weinbrenner, Dieter Flockerzi, Raimund Külzer, Hermann Tenor, Hans-Peter Kley
  • Triazolophthalazines
    Patent number: 7851472
    Abstract: The compounds of formula I in which R1 and R2 have the meanings as given in the description are novel effective PDE2 inhibitors.
    Type: Grant
    Filed: August 31, 2005
    Date of Patent: December 14, 2010
    Assignee: NYCOMED GmbH
    Inventors: Beate Schmidt, Steffen Weinbrenner, Dieter Flockerzi, Raimund Kuelzer, Hermann Tenor, Hans-Peter Kley
  • 3-oxa-10-aza-phenanthrenes
    Patent number: 7838521
    Abstract: The compounds of formula I in which R1, R2 and R3 have the meanings as given in the description, are novel effective PDE4 inhibitors.
    Type: Grant
    Filed: September 5, 2005
    Date of Patent: November 23, 2010
    Assignee: NYCOMED GmbH
    Inventors: Dieter Flockerzi, Ulrich Kautz, Armin Hatzelmann, Christof Zitt, Andrea Wohlsen, Degenhard Marx, Hans-Peter Kley, Jens Christoffers, Anna Rosiak
  • TRIAZOLOPHTHALAZINES
    Publication number: 20100286140
    Abstract: The compounds of formula I in which R1 and R2 have the meanings as given in the description are novel effective PDE2 inhibitors.
    Type: Application
    Filed: April 23, 2010
    Publication date: November 11, 2010
    Applicant: NYCOMED GMBH
    Inventors: Beate SCHMIDT, Steffen WEINBRENNER, Dieter FLOCKERZI, Raimund KUELZER, Hermann TENOR, Hans-Peter KLEY
  • Use of PDE4 inhibitors for the treatment of diabetes mellitus
    Patent number: 7776893
    Abstract: The invention relates to the use of certain known PIDE4 inhibitors for the treatment of diabetes mellitus and accompanying disorders thereof.
    Type: Grant
    Filed: September 2, 2004
    Date of Patent: August 17, 2010
    Assignee: NYCOMED GmbH
    Inventor: Hans-Peter Kley
  • PYRAZOLONE DERIVATIVES AS PDE4 INHIBITORS
    Publication number: 20100120757
    Abstract: The compounds of a certain formula 1, in which R1, R7, R8, R9 and n have the meanings as given in the description, are novel effective inhibitors of the type 4 phosphodiesterase.
    Type: Application
    Filed: May 14, 2008
    Publication date: May 13, 2010
    Applicant: NYCOMED GmbH
    Inventors: Beate Schmidt, Christian Scheufler, Juergen Volz, Martin Feth, Rolf-Peter Hummel, Armin Hatzelmann, Christof Zitt, Andrea Wohlsen, Degenhard Marx, Hans-Peter Kley, Deborah Ockert, Anke Heuser, Johannes A.M. Christiaans, Geert Jan Sterk, Wiro M.P.B. Menge