Abstract: The invention relates to activators of soluble guanylate cyclase and their use in pharmaceutical compositions, primarily topically administered ophthalmic compositions. The pharmaceutical compositions are useful for reducing intraocular pressure in animals of the mammalian species.

Abstract: Self-pumping spring and damper unit (13) with automatically activated ride level control system for chassis of vehicles having a pump which is driven as a result of the distance between the articulation points (14, 15) which changes as a result of the spring compression and spring extension of the vehicle, wherein an elastic connecting element (35) is arranged between at least one pump part (33) and the associated articulation point (14) in such a way that it at least partially elastically compensates the distance between the pump parts (32, 33) which changes when the vehicle experiences spring compression and spring extension.

Abstract: Nitroderivatives of prostaglandins having improved pharmacological activity and enhanced tolerability are described. They can be employed for the treatment of glaucoma and ocular hypertension.

Abstract: An air spring and shock absorber unit for bicycles or motorbikes includes operator control elements which are accessible from the outside and are disposed on an outer surface of the air spring and shock absorber unit. The operator control elements are disposed so as to be rotatable about a common axis and relative to a position of articulation points.

Abstract: Disclosed is a ride level control system for a motor vehicle composed of a pneumatic spring (1), a connecting line (3) which connects the pneumatic spring (1) to an atmospheric port (5), and a first valve (2) which, in a first switched state, disconnects the connecting line (3) and, in a second switched state, clears it, wherein a vessel (4) is arranged in the connecting line (3) between the first valve (2) and the atmospheric port (5).

Abstract: Nitroderivatives of prostaglandins having improved pharmacological activity and enhanced tolerability are described. They can be employed for the treatment of glaucoma and ocular hypertension.

Abstract: Nitroderivatives of prostaglandin amides having improved pharmacological activity and enhanced tolerability are described. They can be employed for the treatment of glaucoma and ocular hypertension.

Abstract: Self-pumping spring and damper unit (13) with automatically activated ride level control system for chassis of vehicles having a pump which is driven as a result of the distance between the articulation points (14, 15) which changes as a result of the spring compression and spring extension of the vehicle, wherein an elastic connecting element (35) is arranged between at least one pump part (33) and the associated articulation point (14) in such a way that it at least partially elastically compensates the distance between the pump parts (32, 33) which changes when the vehicle experiences spring compression and spring extension.

Abstract: Nitroderivatives of prostaglandin amides having improved pharmacological activity and enhanced tolerability are described. They can be employed for the treatment of glaucoma and ocular hypertension.

Abstract: An air spring has three air spring spaces (1, 2, 3). the first and the third space increase and decrease in the same direction, while the second space increases when the other two decrease and vice versa. Connectin channels(14) between the first and the second space as well as between the first and the third space are provided with adjustable restrictors (13, 13’) to control the air flow between the chambers.

Abstract: Disclosed is a ride level control system for a motor vehicle composed of a pneumatic spring (1), a connecting line (3) which connects the pneumatic spring (1) to an atmospheric port (5), and a first valve (2) which, in a first switched state, disconnects the connecting line (3) and, in a second switched state, clears it, wherein a vessel (4) is arranged in the connecting line (3) between the first valve (2) and the atmospheric port (5).

Abstract: An air spring and shock absorber unit for bicycles or motorbikes includes operator control elements which are accessible from the outside and are disposed on an outer surface of the air spring and shock absorber unit. The operator control elements are disposed so as to be rotatable about a common axis and relative to a position of articulation points.

Abstract: Generic spring/damper units are either too big or require too much mounting space or have only relatively small spring/damper compartments and are therefore not sufficiently efficient. To improve the ratio between the overall size of a spring/damper unit and the size of the damper or spring/damper compartments of the spring/damper unit, the overflow throttles (21, 22) are arranged in the cylinder housing (1) between the damper compartment (10) that is increased in size during spring compression and the spring compartment (17) that is reduced in size during spring compression, thereby reducing the dimensions of the separating piston (6) and the piston rod (7) and making the overflow throttles (21, 22) more accessible from the exterior.

Abstract: The invention relates to a system which includes an air spring (2) which, in turn, encloses an air volume (16). The system also includes a controllable shock absorber (4) connected in parallel to the air volume. Furthermore, the system includes an ancillary volume (22) with which the air volume (16) of the air spring (2) is connected via a controllable throttle (20). The stiffness and the total damping of the system can be pregiven via a control of the throttle (20) and of the controllable shock absorber (4) independently of each other.