Abstract: The present invention relates to a method aiding in the assessment of rheumatoid arthritis. The method especially is used in the differential diagnosis of rheumatoid arthritis in vitro. The method is for example practiced by analyzing biochemical markers, comprising measuring in a sample both the concentration of anti-CCP and of antinuclear antibodies (ANA) correlating the concentrations determined to the diagnosis of rheumatoid arthritis. To further improve the assessment of RA in a method of this invention the level of one or more additional marker may be determined together with anti-CCP and ANA and be correlated to the absence or presence of RA. The invention also relates to the use of a marker panel comprising anti-CCP and ANA in the diagnosis of rheumatoid arthritis and it teaches a kit for performing the method of the invention.

Abstract: The present invention relates to a method for establishing a diagnosis if an individual has suffered from or a prognosis if an individual is at risk of suffering from a coronary heart event, which method comprises determining the concentration of sCD40L in a body fluid of the individual; determining the concentration of a proximal inflammatory marker, preferably PAPP-A or Lp-PLA2 comparing the values obtained with reference values; and establishing the diagnosis or the prognosis in respect to the cardiovascular event. The combination according to the invention can be used with further markers selected from further inflammatory markers, anti-inflammatory markers and/or neurohumoral markers.

Abstract: A process is described for the recombinant production of ribonucleoproteins in prokaryotic cells.

Abstract: A process is described for the recombinant production of ribonucleoproteins in prokaryotic cells.