Patents by Inventor Hans-Peter Niedermann

Hans-Peter Niedermann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210317077
    Abstract: The present disclosure encompasses crystalline forms of N1-(1-cyanocyclopropyl)-N2-((1S)-1-{4?-[(1R-2,2-difluoro-1-hydroxyethyl]biphenyl-4-yl}-2,2,2-trifluoroethyl)-4-fluoro-L-leucinamide and processes for the preparation thereof.
    Type: Application
    Filed: August 1, 2019
    Publication date: October 14, 2021
    Applicant: Intervet Inc.
    Inventors: Xiaoling Jin, Dirk Stueber, Cynthia Bazin, Rositza Iordanova Petrova, Christophe Pierre Alain Chassaing, Hans Peter Niedermann, Stephan Veit, Claudia Scheipers, Jochen Schoell
  • Publication number: 20210300863
    Abstract: A method of preparing a compound of Formula (I) comprising reacting the compound of Formula (A) with a base and a compound of Formula (B) to yield a compound of Formula (C).
    Type: Application
    Filed: August 1, 2019
    Publication date: September 30, 2021
    Applicant: Intervet Inc.
    Inventors: Eric Voight, Christophe Pierre Alain Chassaing, Hans Peter Niedermann, Stephan Veit, Claudia Scheipers
  • Publication number: 20210107874
    Abstract: The present invention is directed to a salt of a compound of formula (I), R1 is halogen or methyl; X is methyl, OR2, or SR2; Y1, Y2 is CR3 or N, and one of Y1, Y2 is N and one of Y1, Y2 is CR3; R2 is methyl or ethyl; R3 is hydrogen or methyl, wherein the salt is chosen from the group 10 consisting of malate salt, citrate salt, tartrate salt, oxalate salt, fumarate salt, lactate salt, glucoronate salt, oxoglucoronate salt, ethanesulfonate salt, and succinate salt. The present invention is further related to a pharmaceutical formulation comprising the salt of the invention wherein the base compound is present in an amount of 2-30% (w/v) and having a pH value of at least 3.7 and to methods of treatment using the salt of the invention.
    Type: Application
    Filed: March 30, 2018
    Publication date: April 15, 2021
    Applicant: Intervet Inc.
    Inventors: Michael Berger, Hans Peter Niedermann, Marcus Knell, Anne Lehay, Angelique Duval, Anne-Laure Morer, Susi Alteheld
  • Publication number: 20200283389
    Abstract: An improved process for producing a compound of Formula (I).
    Type: Application
    Filed: December 22, 2016
    Publication date: September 10, 2020
    Applicant: Intervet Inc.
    Inventors: Michael Berger, Hans Peter Niedermann, Tobias Kappesser, Stephan Veit, Heiko Bothe, Marcus Knell, Christophe Pierre Alain Chassaing
  • Patent number: 10562834
    Abstract: A process to prepare a compound of Formula (I) wherein R3, R4 and R5 are each selected independently from hydrogen, halogen, alkyl, alkenyl, alkynyl, alkoxyl, and wherein the alkyl, alkenyl, alkynyl, and alkoxyl may be optionally substituted with one or more halogen, alkyl, alkenyl, alkynyl, and alkoxyl.
    Type: Grant
    Filed: January 4, 2019
    Date of Patent: February 18, 2020
    Assignee: Intervet Inc.
    Inventors: Michael Berger, Stephan Veit, Hans Peter Niedermann, Tobias Kappesser, Alfred Stutz
  • Publication number: 20190135725
    Abstract: A process to prepare a compound of Formula (I) wherein R3, R4 and R5 are each selected independently from hydrogen, halogen, alkyl, alkenyl, alkynyl, alkoxyl, and wherein the alkyl, alkenyl, alkynyl, and alkoxyl may be optionally substituted with one or more halogen, alkyl, alkenyl, alkynyl, and alkoxyl.
    Type: Application
    Filed: January 4, 2019
    Publication date: May 9, 2019
    Applicant: Intervet Inc.
    Inventors: Michael Berger, Stephan Veit, Hans Peter Niedermann, Tobias Kappesser, Alfred Stutz
  • Publication number: 20170121265
    Abstract: A process to prepare a compound of Formula (I) wherein R3, R4 and R5 are each selected independently from hydrogen, halogen, alkyl, alkenyl, alkynyl, alkoxyl, and wherein the alkyl, alkenyl, alkynyl, and alkoxyl may be optionally substituted with one or more halogen, alkyl, alkenyl, alkynyl, and alkoxyl.
    Type: Application
    Filed: May 20, 2015
    Publication date: May 4, 2017
    Applicant: Intervet Inc.
    Inventors: Michael Berger, Stephan Veit, Hans Peter Niedermann, Tobias Kappesser, Alfred Stutz
  • Patent number: 9066864
    Abstract: Disclosed is a method of making particles of a drug wherein use is made of diafiltration. The diafiltration can be with anti-solvent, in which case a precipitate is obtained of particles as such. The diafiltration can also be with a pharmaceutically acceptable suspension medium. In that case several process steps of isolating, drying, transporting of particles can be avoided, because the suspension resulting from the synthesis of the particles is directly turned into a final drug product formulation.
    Type: Grant
    Filed: January 11, 2012
    Date of Patent: June 30, 2015
    Assignee: Intervet Inc.
    Inventors: Hans Peter Niedermann, Heiko Bothe
  • Publication number: 20130281425
    Abstract: Disclosed is a method of making particles of a drug wherein use is made of diafiltration. The diafiltration can be with anti-solvent, in which case a precipitate is obtained of particles as such. The diafiltration can also be with a pharmaceutically acceptable suspension medium. In that case several process steps of isolating, drying, transporting of particles can be avoided, because the suspension resulting from the synthesis of the particles is directly turned into a final drug product formulation.
    Type: Application
    Filed: January 11, 2012
    Publication date: October 24, 2013
    Applicant: Intervet International B.V.
    Inventors: Hans Peter Niedermann, Heiko Bothe
  • Publication number: 20130274270
    Abstract: Polymorphs of 3-chloro-4[(2R)-2-(4-chlorophenyl)-4-[(1R)-1-(4-cyanophenyl)ethyl]-1-piperazinyl]-benzonitrile are disclosed, as well as pharmaceutical compositions comprising said polymorphs, methods of using the polymorphs, and a process for preparing them.
    Type: Application
    Filed: December 21, 2011
    Publication date: October 17, 2013
    Inventors: Monika Brink, Hans-Peter Niedermann, Marcus Knell, Tao Feng, Scott T. Trzaska, Arthur J. Cooper, Shaileshkumar Ramanial Desai, Vinayak Keshav Gore
  • Publication number: 20120122832
    Abstract: Disclosed is a process for the production of particles of a cefquinome acid addition salt, preferably cefquinome sulfate particles, by precipitation of cefquinome acid addition salt, preferably the sulfate, from a cefquinome betaine solution, wherein acid, preferably sulfuric acid, is added to the betaine solution. According to the invention the acid, preferably sulfuric acid, is added quickly in a single shot, in a molar excess of 40% to less than 100%. As a result, particles are formed that comprise agglomerates of microscale primary crystalline particles. This enables providing particles of cefquinome acid addition salt, preferably cefquinome sulfate, in particle sizes commensurate with micronized material, but with improved stability.
    Type: Application
    Filed: July 19, 2010
    Publication date: May 17, 2012
    Inventors: Hans Peter Niedermann, Heiko Bothe
  • Publication number: 20110053875
    Abstract: This invention relates to a method for making macrolides, and, in particular, a method for making optionally substituted 20,23-dipiperidinyl-5-O-mycaminosyl-tylonolide and derivatives thereof, as well as uses of macrolides to make medicaments, methods of treatment using macrolides, and methods for making intermediates that, inter alia, may be used to make macrolides. This invention also relates to solvated and non-solvated crystalline forms of 20,23-dipiperidinyl-5-O-mycaminosyl-tylonolide, as well as methods for making such crystalline forms, medicaments comprising (or derived from) such crystalline forms, methods for making medicaments comprising (or derived from) such crystalline forms, methods of treatment using such crystalline forms, and kits comprising such crystalline forms.
    Type: Application
    Filed: July 30, 2010
    Publication date: March 3, 2011
    Inventors: Fritz Blatter, Meinrad Brenner, Monika Brink, Kerstin Fleischhauer, Guixian Hu, Hans Peter Niedermann, Timo Rager, Tanja Schweisel, Stephan Veit, Ralf Warrass, Heinz-J├Ârg Wennesheimer
  • Publication number: 20090042815
    Abstract: This invention relates to a method for making macrolides, and, in particular, a method for making optionally substituted 20,23-dipiperidinyl-5-O-mycaminosyl-tylonolide and derivatives thereof, as well as uses of macrolides to make medicaments, methods of treatment using macrolides, and methods for making intermediates that, inter alia, may be used to make macrolides. This invention also relates to solvated and non-solvated crystalline forms of 20,23-dipiperidinyl-5-O-mycaminosyl-tylonolide, as well as methods for making such crystalline forms, medicaments comprising (or derived from) such crystalline forms, methods for making medicaments comprising (or derived from) such crystalline forms, methods of treatment using such crystalline forms, and kits comprising such crystalline forms.
    Type: Application
    Filed: July 26, 2007
    Publication date: February 12, 2009
    Applicant: Intervet International B.V.
    Inventors: Fritz Blatter, Meinrad Brenner, Monika Brink, Kerstin Fleischhauer, Guixian Hu, Hans Peter Niedermann, Timo Rager, Tanja Schweisel, Stephan Veit, Ralf Warrass, Heinz-Jorg Wennesheimer
  • Patent number: 6307103
    Abstract: An improved process for the preparation of a 1,1,1-trifluoro-2-aminoalkane of formula I wherein R1 represents an optionally substituted alkyl group; which comprises hydrogenating the corresponding oxime of formula II wherein R1 has the meaning given above and the winding line indicates that the hydroxy group may be in the (E)- or (Z)-position with respect to the trifluoromethyl group, in the presence of Raney nickel and a diluent; the improvement wherein is, that said reaction is carried out in a diluent selected from an alkanol, a cyclic ether and an aromatic hydrocarbon.
    Type: Grant
    Filed: March 28, 2000
    Date of Patent: October 23, 2001
    Assignee: American Cyanamid Company
    Inventors: Hans-Peter Niedermann, Dieter Gutheil
  • Patent number: 6166259
    Abstract: The invention relates to a process for the preparation of a 1,1,1-trifluoro-2-aminoalkane of formula I ##STR1## wherein R.sup.1 represents an optionally substituted alkyl group; which comprises heating a mixture consisting essentially of a compound of formula II ##STR2## wherein R.sup.1 has the meaning given, and R.sup.2 represents an optionally substituted aryl group, a primary amine, and optionally a base and/or an inert diluent, whereby the compound of formula I is removed by distillation during the heating procedure.
    Type: Grant
    Filed: March 28, 2000
    Date of Patent: December 26, 2000
    Assignee: American Cyanamid Company
    Inventors: Rudi Eisenacht, Hans-Peter Niedermann, Dieter Landau
  • Patent number: 5759956
    Abstract: A compound of the general formula (I) ##STR1## wherein A represents a group of general formula ##STR2## and R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, X, Q.sup.2, Q.sup.3, and n are as described in the specification. The compounds of formula (I) are useful as agricultural herbicides.
    Type: Grant
    Filed: May 8, 1996
    Date of Patent: June 2, 1998
    Assignee: American Cyanamid Company
    Inventors: Hans-Peter Niedermann, Rudi Eisenacht
  • Patent number: 5693594
    Abstract: A compound of general formula (I) wherein: A represents a group of general formula (1) or (2) in which each X independently represents a halogen atom or an optionally substituted alkyl, cycloalkyl, alkoxy, aryl or aryloxy group, or an alkenyloxy, alkynyloxy, alkylthio, haloalkylthio, alkenylthio, alkynylthio, alkylsulphinyl, alkylsulphonyl or cyano group; and n is 0, an integer from 1 to 4, or, for the phenyl group, 5; or A represents a group of general formula (3) in which each of R.sup.4, R.sup.5 and R.sup.6 independently represents a hydrogen or halogen atom, an optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, alkaryl alkoxy, amino, mono- or di-alkylamino, alkoxycarbonylamino, arylamino, dialkylcarbamoyl, acyl or acylamido group or a cyano group, with the proviso that R.sup.5 and R.sup.6 do not represent an acyl, acylamido or cyano group; Z represents an oxygen or sulphur atom; R.sup.1 and R.sup.
    Type: Grant
    Filed: April 25, 1996
    Date of Patent: December 2, 1997
    Assignee: American Cyanamid Company
    Inventors: Hans-Peter Niedermann, Dieter Gutheil