Abstract: The present invention includes a device comprising a lid and a vessel forming an interface that allows transfer of waste from a purification chamber to a waste chamber and method for purification of an analyte are disclosed wherein a supernatant is separated from a solid phase to which an analyte is bound by centrifugation via the lid of the device. The present invention also includes methods for use of the device.

Abstract: A sample collection tube is disclosed for collecting a body fluid sample. The tube includes a closure arranged at an open end to close the open end and a partially evacuated inner space. The closure also includes a base portion connected to the sidewall and a cap portion coupled to the base portion, where the cap portion has an elastomeric material that is pierceable from outside of the tube for collecting a sample into the partially evacuated inner space and where the cap portion can be pivotable with respect to the sidewall such as to make the inner space accessible for withdrawing an aliquot of the sample. Alternatively, the cap portion can be separable from the base portion to make the inner space accessible and the base portion can include a self-resealable valve adapted to allow access of a pipetting unit into the inner space when the cap portion is separated and adapted to re-seal after withdrawal of the pipetting unit. Also disclosed is a work cell for handling sample collection tubes.

Abstract: A microfluidic system having a microchannel for the capillary transport of a liquid, in particular a body fluid for analytical purposes. The microchannel is provided with a surface coating comprising at least one hydrophilic substance selected from the group consisting of polyacrylic acid, polyacrylate, dextran sulfate and chondroitin sulfate. The invention also concerns a coating method that is suitable for this.

Abstract: A sealing cap for a body fluid container, and a body fluid collection device and system are disclosed. The sealing cap includes an inner cap placeable on an opening in the body fluid container forming a mouth, the inner cap has a shielding member which seals the mouth of the body fluid container, an outer cap resting on the inner cap, the outer cap being movable relative to the inner cap, and a channel member, wherein by a rotational movement the outer cap is movable between an first position in which the channel member is located separated from the shielding member and a second position in which the channel member extends through the shielding member, thereby establishing an open state of the shielding member, and wherein the shielding member returns to a closed state when the outer cap is moved back from the second position to the first position.

Abstract: The invention is directed to a disposable sample holding and processing device (1) dimensioned for being operated in a nucleic acid amplification apparatus for analyzing a liquid sample containing a nucleic acid by a nucleic acid amplification technique. The device (1) comprises chambers (15, 16) and channels (44) designed to perform the steps of capturing, amplification and detection of the nucleic acid within the device (1), and optionally also a lysis chamber (3). The binding chamber (15) contains a solid phase (14) for immobilization of a component of the sample to be analyzed, and the amplification chamber (16) is connected to the binding chamber (15) by a fluid channel (44).

Abstract: The present invention includes a container and a method of separating one or more components of interest bound to magnetic particles using centrifugal forces.

Abstract: A pipette tip and a method for pipetting a congealed blood sample utilizing the pipette tip are disclosed. The pipette tip includes an attachment section configured to be attached to a dispensing device, a liquid containing section configured to receive at least part of an aspired liquid sample, and a liquid aspiration section that is connected to the liquid containing section. The liquid aspiration section has a distal end aspiration opening and at least one further aspiration opening in a side wall.

Abstract: The present invention includes a container and a method of separating one or more components of interest bound to magnetic particles using centrifugal forces.

Abstract: A method for determining analytes in a liquid is provided comprising applying a liquid volume to be examined to a substrate of a transport plane; moving the liquid volume to be examined on the substrate of the transport plane to a site of examination; contacting the liquid volume to be examined with at least one sensory element, wherein the sensory element is located in a detection plane opposite to the substrate of the transport plane; and determining an analyte in the liquid volume to be examined by the sensory element, wherein the liquid volume is only in contact with the substrate of the transport plane during the step of moving the liquid volume to be examined on the substrate of the transport plane to a site of examination. The application also concerns a device for determining analytes in a liquid corresponding to the method according to the invention.

Abstract: The present invention pertains to a device for separating plasma from a blood sample comprising a stacked structure which is provided with a first portion including a separating member having a first surface for applying or receiving the blood sample, wherein the separating member is adapted to permit the passage of plasma but to inhibit the passage of cells, and a second portion including an absorptive member for absorbing the plasma, which has a second surface in contact with the separating member for receiving the plasma, wherein the absorptive member is adapted to generate a capillary pressure so as to draw plasma from the separating member to the absorptive member. The first portion is fixed to the backing member in a manner to be removed without destroying the absorptive member. The absorptive member is fixed to the backing member in a manner to be removed without destroying the absorptive member.

Abstract: A device for separating at least part of the liquid component of a blood sample and methods thereof are disclosed. Generally, the device includes a container body for receiving the blood sample, a layer of retaining porous material, a layer of separating permeable material. The retaining porous material retains non-liquid components of the blood sample after the non-liquid components have been subjected to centrifugal force which forces them through the separating permeable material into the retaining porous material.

Abstract: The present invention includes a container and a method of separating one or more components of interest bound to magnetic particles using centrifugal forces.

Abstract: The present invention includes a device comprising a lid and a vessel forming an interface that allows transfer of waste from a purification chamber to a waste chamber and method for purification of an analyte are disclosed wherein a supernatant is separated from a solid phase to which an analyte is bound by centrifugation via the lid of the device. The present invention also includes methods for use of the device.

Abstract: A sealing cap for a body fluid container, and a body fluid collection device and system are disclosed. The sealing cap includes an inner cap placeable on an opening in the body fluid container forming a mouth, the inner cap has a shielding member which seals the mouth of the body fluid container, an outer cap resting on the inner cap, the outer cap being movable relative to the inner cap, and a channel member, wherein by a rotational movement the outer cap is movable between an first position in which the channel member is located separated from the shielding member and a second position in which the channel member extends through the shielding member, thereby establishing an open state of the shielding member, and wherein the shielding member returns to a closed state when the outer cap is moved back from the second position to the first position.

Abstract: A pipette tip and a method for pipetting a congealed blood sample utilizing the pipette tip are disclosed. The pipette tip includes an attachment section configured to be attached to a dispensing device, a liquid containing section configured to receive at least part of an aspired liquid sample, and a liquid aspiration section that is connected to the liquid containing section. The liquid aspiration section has a distal end aspiration opening and at least one further aspiration opening in a side wall.

Abstract: A device for separating at least part of the liquid component of a blood sample and methods thereof are disclosed. Generally, the device includes a container body for receiving the blood sample, a layer of retaining porous material, a layer of separating permeable material. The retaining porous material retains non-liquid components of the blood sample after the non-liquid components have been subjected to centrifugal force which forces them through the separating permeable material into the retaining porous material.

Abstract: The invention is directed to a disposable sample holding and processing device (1) dimensioned for being operated in a nucleic acid amplification apparatus for analyzing a liquid sample containing a nucleic acid by a nucleic acid amplification technique. The device (1) comprises chambers (15, 16) and channels (44) designed to perform the steps of capturing, amplification and detection of the nucleic acid within the device (1), and optionally also a lysis chamber (3). The binding chamber (15) contains a solid phase (14) for immobilization of a component of the sample to be analyzed, and the amplification chamber (16) is connected to the binding chamber (15) by a fluid channel (44).

Abstract: The embodiments of the present invention are directed to an automatic apparatus (55), which is designed for performing nucleic acid analysis, optionally including sample preparation, with integrated disposable sample holding and processing devices (1), which devices (1) comprise a sample to be analyzed with the apparatus (55). The apparatus (55) comprises workstations (17, 40) for receiving, holding and processing such integrated disposable devices (1), a reagents station (56) for reagents (25), transfer means (36) for performing movements of an actuator, fluid actuation means for processing the sample (32) and reagents in said disposable devices (1), temperature control means (37) for heating or cooling, detection means for measuring a property of the processed samples (32), and control means for controlling the sample (32) preparation, the handling of the disposable devices (1) and the sample analysis performed by the apparatus (55).

Abstract: In the case of a disposable lancing element for collecting body fluid through the skin comprising a support and a lancing member which distally projects therefrom and can pierce the skin in a lancing movement, it is proposed that a pretensioning means which tightens the skin in the area of the puncture site is arranged on the support and has a contact member which impacts the skin laterally from the lancing member during the lancing movement.

Abstract: A device and method thereof for at least partially fractioning or separating fluid from higher density and/or solid particles contained in liquid samples are disclosed. The present invention provides a movable or drivable device having a flow path defined by inner and outer wall surfaces and arranged such that the flow velocity of the liquid sample along the outer wall surface is higher than the flow velocity along the opposite inner wall surface. The flow path provides elements to at least delay the flow of the liquid sample along the outer wall surface. The device is, e.g., suitable for the separation of blood, e.g., of plasma from at least red blood cells, and from red and white blood cells to achieve blood plasma with high purity for analytical reasons.