Abstract: The present invention relates to nanoparticles comprising nucleic acids coated with a (biodegradable) polymer for reversible immobilization and/or controlled release of the nucleic acid comprising nanoparticles. Furthermore, the present invention is directed to medical or diagnostic devices, particularly stents and implants coated by a (biodegradable) polymer with the nucleic acid comprising nanoparticles for reversible immobilization and/or controlled release. Furthermore, the present invention is directed to the use of these nanoparticles coated with a (biodegradable) polymer and to the use of medical devices and implants coated by the (biodegradable) polymer with these nucleic acid comprising nanoparticles in the prophylactic or therapeutic treatment of diseases, particularly in the prevention or treatment of restenosis, calicification, foreign body reaction, or inflammation.

Abstract: The invention relates to a polyribonucleotide, a cosmetic and pharmaceutical compound that has the polyribonucleotide and a medicinal product that has the polyribonucleotide and the compound.

Abstract: The invention relates to a medical device for use in human vessels, in particular in the carotid artery, comprising: a self-expandable mesh structure which at least partially forms a curved wall, and has, in a radially compressed state, a cross-sectional diameter of not more than 2.5 mm, wherein the mesh structure is formed of at least one mesh structural element which has a height that is no more than 200 ?m, in particular no more than 150 ?m, preferably no more than 70 ?m, where the height is measurable along a diameter of the mesh structure, and wherein the mesh structure is at least partially formed of a nickel titanium alloy and is at least partially coated in fibrin.

Abstract: The present invention relates to nanoparticles comprising nucleic acids coated with a (biodegradable) polymer for reversible immobilization and/or controlled release of the nucleic acid comprising nanoparticles. Furthermore, the present invention is directed to medical or diagnostic devices, particularly stents and implants coated by a (biodegradable) polymer with the nucleic acid comprising nanoparticles for reversible immobilization and/or controlled release. Furthermore, the present invention is directed to the use of these nanoparticles coated with a (biodegradable) polymer and to the use of medical devices and implants coated by the (biodegradable) polymer with these nucleic acid comprising nanoparticles in the prophylactic or therapeutic treatment of diseases, particularly in the prevention or treatment of restenosis, calicification, foreign body reaction, or inflammation.

Abstract: The invention relates to a polyribonucleotide, a cosmetic and pharmaceutical compound that has the polyribonucleotide and a medicinal product that has the polyribonucleotide and the compound.

Abstract: A composition for cleaning, disinfecting, protective treatment, or a combination thereof of technical surfaces contains microparticles loaded with an antibacterially effective ingredient. The antibacterially effective ingredient can be totarol. Microparticles loaded with totarol can be used for the coating of medical implants. Medical implants coated with a composition for cleaning, disinfecting, protective treatment or a combination thereof are provided.

Abstract: The present invention relates to nanoparticles comprising nucleic acids coated with a (biodegradable) polymer for reversible immobilization and/or controlled release of the nucleic acid comprising nanoparticles. Furthermore, the present invention is directed to medical or diagnostic devices, particularly stents and implants coated by a (biodegradable) polymer with the nucleic acid comprising nanoparticles for reversible immobilization and/or controlled release. Furthermore, the present invention is directed to the use of these nanoparticles coated with a (biodegradable) polymer and to the use of medical devices and implants coated by the (biodegradable) polymer with these nucleic acid comprising nanoparticles in the prophylactic or therapeutic treatment of diseases, particularly in the prevention or treatment of restenosis, calicification, foreign body reaction, or inflammation.

Abstract: The present invention relates to a nucleic acid molecule, a genetic construct, siRNA molecules and a composition which comprises the nucleic acid molecule and/or the genetic construct and/or the siRNA molecules and can be used for inhibition of the expression of endothelial adhesion molecules. The invention also relates to a device, which is coated with the aforementioned molecules, the composition or the construct, or contains them. The present invention further relates to a corresponding use of the nucleic acid molecule, of the genetic construct or of the siRNA molecules and a method of inhibition of the expression of adhesion molecules and a method of vessel grafting, lung transplantation, treatment of lung transplants, and a method of treatment of the open heart within the scope of cardioplegia.

Abstract: The invention relates to a device comprising at least one surface which comes into contact with biological tissue and/or liquid, which is at least partially coated with a substance which mediates the binding of mesenchymal stem cells (MSCs), a method for the binding and/or isolation of MSCs from biological tissue and/or liquid, a nucleic acid molecule which selectively and highly specifically binds to MSCs, the use of the nucleic acid molecule for the binding and/or isolation of MSCs from biological tissue and/or liquid, as well as a method for the production of a device mentioned at the outset.

Abstract: The present invention relates to a nucleic acid molecule, a genetic construct, siRNA molecules and a composition which comprises the nucleic acid molecule and/or the genetic construct and/or the siRNA molecules and can be used for inhibition of the expression of endothelial adhesion molecules. The invention also relates to a device, which is coated with the aforementioned molecules, the composition or the construct, or contains them. The present invention further relates to a corresponding use of the nucleic acid molecule, of the genetic construct or of the siRNA molecules and a method of inhibition of the expression of adhesion molecules and a method of vessel grafting, lung transplantation, treatment of lung transplants, and a method of treatment of the open heart within the scope of cardioplegia.

Abstract: The present invention relates to a sealing plug for an opening in a wall of a vessel or hollow organ of an animal or human body, in particular a blood vessel, to a device for placing such a sealing plug in such an opening, to a surgery kit for percutaneously sealing an opening in a wall of a vessel or hollow organ of an animal or human body, in particular a blood vessel, and to a method for percutaneously sealing of an opening in a wall of a vessel or hollow organ of an animal or human body.

Abstract: Devices having at least one surface which comes into contact with tissues and/or fluids of the human or animal body. These surfaces are at least partially coated with aptamers, which mediate the adhesion of biological material.