Abstract: In a hearing aid (26) that can be inserted into the ear canal (12) of a patient, comprising an actuator (31) effecting a mechanical stimulation of the tympanic membrane (14), the actuator (31) comprises an inner surface (32) associated with the tympanic membrane (14) and an outer surface (42) associated with the ear canal (12) and is configured as an areal disk actuator, whose deformation stimulates the tympanic membrane (14) by areal deformation. On the actuator (31) at a distance from the outer surface (42) a cover plate (43) is arranged which together with the outer surface (42) delimits a preferably lenticular cavity (48).

Abstract: In a hearing aid (26) that can be inserted into the ear canal (12) of a patient, comprising an actuator (31) effecting a mechanical stimulation of the tympanic membrane (14), the actuator (31) comprises an inner surface (32) associated with the tympanic membrane (14) and an outer surface (42) associated with the ear canal (12) and is configured as an areal disk actuator, whose deformation stimulates the tympanic membrane (14) by areal deformation. On the actuator (31) at a distance from the outer surface (42) a cover plate (43) is arranged which together with the outer surface (42) delimits a preferably lenticular cavity (48).

Abstract: In a hearing aid (26) that can be inserted into the ear canal (12) of a patient, comprising an actuator (31) effecting a mechanical stimulation of the tympanic membrane (14), the actuator (31) comprises an inner surface (32) associated with the tympanic membrane (14) and an outer surface (42) associated with the ear canal (12) and is configured as an areal disk actuator, whose deformation stimulates the tympanic membrane (14) by areal deformation. On the actuator (31) at a distance from the outer surface (42) a cover plate (43) is arranged which together with the outer surface (42) delimits a preferably lenticular cavity (48).

Abstract: In a hearing aid (26) that can be inserted into the ear canal (12) of a patient, comprising an actuator (31) effecting a mechanical stimulation of the tympanic membrane (14), the actuator (31) comprises an inner surface (32) associated with the tympanic membrane (14) and an outer surface (42) associated with the ear canal (12) and is configured as an areal disk actuator, whose deformation stimulates the tympanic membrane (14) by areal deformation. On the actuator (31) at a distance from the outer surface (42) a cover plate (43) is arranged which together with the outer surface (42) delimits a preferably lenticular cavity (48).

Abstract: In a hearing aid having a microphone to be arranged at a body of a user for capturing ambient sound, a loudspeaker for outputting the ambient sound after having been amplified on a frequency-dependent basis, and a signal processor, the signal processor is configured to amplify the sound such that the amplified sound is audible to the user, and to automatically re-adjust the gain by the following steps: selecting a tone having a specific frequency; outputting the tone and the amplified ambient sound via the loudspeaker as an output sound; capturing via said microphone an analysis sound composed of ambient sound and of a reflection of said output sound; extracting a reflection of the tone from the captured analysis sound; and determining a reflection component for the specific frequency of the tone; adjusting the gain in frequency-specific manner and based on the determined reflection component.

Abstract: In a hearing aid having a microphone to be arranged at a body of a user for capturing ambient sound, a loudspeaker for outputting the ambient sound after having been amplified on a frequency-dependent basis, and a signal processor, the signal processor is configured to amplify the sound such that the amplified sound is audible to the user, and to automatically re-adjust the gain by the following steps: selecting a tone having a specific frequency; outputting the tone and the amplified ambient sound via the loudspeaker as an output sound; capturing via said microphone an analysis sound composed of ambient sound and of a reflection of said output sound; extracting a reflection of the tone from the captured analysis sound; and determining a reflection component for the specific frequency of the tone; adjusting the gain in frequency-specific manner and based on the determined reflection component.

Abstract: The invention relates to the use of an active agent, particularly an inhibitor, in treating cancer by influencing, preferably inhibiting the expression of matrix-metalloproteases. The targets for this active agent can especially related to downstream regulators of the matrix-metalloprotease 9 (MMP-9) signal transduction pathway. According to the invention, especially inhibitors of p38beta and p38gamma as also of mitogen-activated kinase kinase 6 (MKK6) and mitogen-activated kinase kinase 3 (MKK3) can be applied.

Abstract: An at least partially implantable system for rehabilitation of a hearing disorder with at least one acoustic sensor (microphone) for picking up an acoustic sensor signal and converting the acoustic sensor signal into corresponding electrical signals, an electronic signal processing unit for audio signal processing and amplification, an electrical power supply unit which supplies individual components of the system with energy, and an output-side actuator stimulation arrangement, the actuator stimulation arrangement has a dual intracochlear arrangement in combination with a stimulator arrangement with at least one stimulator element for at least indirect mechanical stimulation of a damaged inner ear and one electrically acting stimulation electrode arrangement with at least one cochlear implant electrode for electrical stimulation of the inner ear.

Abstract: An at least partially implantable system for rehabilitation of a hearing disorder with at least one acoustic sensor (microphone) for picking up an acoustic sensor signal and converting the acoustic sensor signal into corresponding electrical signals, an electronic signal processing unit for audio signal processing and amplification, an electrical power supply unit which supplies individual components of the system with energy, and an output-side actuator stimulation arrangement, the actuator stimulation arrangement has a dual intracochlear arrangement in combination with a stimulator arrangement with at least one stimulator element for at least indirect mechanical stimulation of a damaged inner ear and one electrically acting stimulation electrode arrangement with at least one cochlear implant electrode for electrical stimulation of the inner ear.

Abstract: In a process for optimization of mechanical inner ear stimulation in an at least partially implantable hearing system for rehabilitation of a hearing impairment with an electromechanical converter which transmits its output-side mechanical vibrational energy via mechanical stimulation of a middle ear ossicle to the damaged inner ear, the ossicular chain is mechanically interrupted such that co-vibration of the eardrum and thus loss of part of the energy supplied by the electromechanical converter by acoustic sound emission is prevented. The process optimizes the flow of mechanical energy supplied by the electromechanical hearing aid converter in the direction of the inner ear.

Abstract: Use of adamantane derivatives of the formula ##STR1## in which R1 and R2 are identical or different and can be hydrogen or straight-chained or branched alkyl groups having 1 to 6 carbon atoms, ortogether with the nitrogen atom can represent a heterocyclic group having 5 or 6 ring atoms,in which R3 and R4 are identical or different and can be hydrogen, straight-chained or branched alkyl groups having between 1 and 6 carbon atoms, cycloalkyl groups having 5 or 6 carbon atoms or a phenyl group, and in which R5 is hydrogen or a straight-chained or branched alkyl group having between 1 and 6 carbon atoms for treating diseases of the inner ear.

Abstract: The invention concerns a device for determining data on auditory capacity, the device having preferably non-contact means for measuring vibrations of the middle-ear ossicles (22, 23, 24) and/or the tympanic membrane (21) by means of electromagnetic waves. The electromagnetic waves used for the measurement are input by means of a microscope (3), in particular an optical microscope (3). This microscope can be modular in design, and a module (5) can be provided for the input of a laser beam (9). The invention also concerns a method of determining data on auditory capacity, the method calling for the vibration of the middle ear and/or the eardrum to be measured by means of electromagnetic waves and, from the measurement signals thus obtained, the contributions to the total signal by the middle ear and/or the eardrum determined in at least one processing step.

Abstract: An implantable dosaging system for medications, active substances, etc. administered in the form of dissolved or suspended fluids having a medication reservoir, a pump for administering the medication, an actuator for the transcutaneous operation of the pump, a self-sealing port, particularly for refilling the medication reservoir and optionally a dosaging line leading from the pump to the administration point of the medication. Preferably there is a housing (2) and a separate medication reservoir (9), in which the pump is located within the housing (2) and the administration of the medication takes place with the aid of a discharge opening provided in the housing (2), the actuator (5) and the self-sealing port (6) are provided on the housing (2), a connecting line (8) is provided between the housing (2) and the medication reservoir (9) and optionally the dosaging line (7) leads from the discharge opening to the administration point of the medication.