Abstract: Compounds of the formula (I) in which R1, R2 and R3 have the meanings indicated in Claim 1, are inhibitors of PDK1 and cell proliferation/cell vitality and can be employed treatment of tumours.

Abstract: A diagnosis and maintenance device is provided for a switchgear assembly, for example, a low-voltage switchgear assembly. The diagnosis and maintenance device includes a data processing device and at least one first, internal interface device, which is connected to at least one connected and communication-capable apparatus in the switchgear assembly in a communicating manner and polls and/or processes the diagnosis and maintenance information and/or status information of the connected and communication-capable apparatus and provides said information in an accessible manner as usable and/or human-readable information and/or outputs and/or displays said information as usable and/or human-readable information. A switchgear assembly having such a device is also provided.

Abstract: This invention relates to modified double-stranded oligoribonucleic acid (dsRNA) having improved stability in cells and biological fluids, and methods of making and identifying dsRNA having improved stability, and of using the dsRNA to inhibit the expression or function of a target gene.

Abstract: The present invention provides improved methods for the manufacturing of IVIG products. These methods offer various advantages such as reduced loss of IgG during purification and improved quality of final products. In other aspects, the present invention provides aqueous and pharmaceutical compositions suitable for intravenous, subcutaneous, and/or intramuscular administration. In yet other embodiments, the present invention provides methods of treating a disease or condition comprising administration of an IgG composition provided herein.

Abstract: The present invention provides a device for mounting systems, for example an electrical or fluid-conveying line, on a structure, in particular of an aircraft or spacecraft, the device comprising a basic holder which is fastenable to the structure and a system holder for mounting the systems, the system holder being fastenable to a first interface of the basic holder, which system holder is fastenable to a first interface of the basic holder; the basic holder comprising a first part, which comprises the first interface, and a second part, one end of which is attachable to the first part so as to be pivotal about a pivot axis and the other end of which is fastenable to the structure.

Abstract: The invention refers to a method for producing means with thermal resist for applying at a surface of a heat exposed component. The method includes providing at least one mixture of at least two different inorganic powder materials: with different chemical composition and thermal expansion coefficient, where at least one of the powder materials experiences volume changes due to crystallographic phase change at a given temperature, and/or\where at least one of the two powder materials experiences volume changes due to chemical composition change, forming the at least one mixture into a green body shape, sintering the green body to obtain a ceramic body and cooling the ceramic body and causing micro-cracking during heating and or/sintering and/or cooling to obtain the means with thermal resist. The forming is performed such that a first mixture forming a first layer onto which a second mixture is applied forming a second layer differs in porosity from that first layer to obtain a layered green body.

Abstract: Methods and apparatus are provided for an integrated circuit with a transistor and a resistor. The method includes depositing a first dielectric layer over the transistor and the resistor, followed by an amorphous silicon layer. The amorphous silicon layer is implanted over the resistor to produce an etch mask, and the amorphous silicon layer and first dielectric layer are removed over the transistor. A contact location on the transistor is then silicided.

Abstract: The invention refers to a method for applying heat resistant protection components onto the surface of a heat exposed component. The method including providing at least two separate heat protection components, and joining the at least two separate heat protection components onto their top surface and/or bottom surface and/or at least one side surface by flexible means for obtaining an integrally handable entity. The method further includes fixing the integrally handable entity by applying and brazing the surface of each heat protection component on the surface of the heat exposed component. The materials of the flexible means and for joining the flexible means on the separate heat protection components are selected such that the materials withstand brazing being performed under protective atmosphere, i.e. an atmosphere without or with reduced amount of oxygen, at process temperatures between 700° C. and 1200° C., and that the materials are burned out after brazing during a following oxidizing thermal step.

Abstract: The application relates to a method for determining beam parameters of a charge carrier beam, a measuring device, and a charge carrier beam device. The charge carrier beam (4) from a charge carrier beam device (1) is guided, by means of a beam deflection unit (3), over a slit aperture arrangement which is provided in an aperture device (7) and which has one or more slit apertures (8). Measurement plane coordinates of the beam components that penetrate the slit aperture arrangement are determined. On the basis of the measurement plane coordinates, the aperture device automatically moves in such a way that a measuring aperture (9) arranged in the aperture device moves over a predefined measurement reference point. The beam parameter is measured by the measuring aperture. In a measuring device (5) suitable for carrying out said method, the slit aperture arrangement has at least two non-parallel slit aperture sections (12, 13, 15, 16) which can be part of a single continuous slit aperture.

Abstract: The 15?,16?-methylene-17-hydroxy-19-nor-17-pregna-4-en-3-one-21-carboxylic acid ?-lactone derivatives of the present invention possess progestational efficacy. They have the general chemical formula I, in which Z is selected from the group comprising an oxygen atom, two hydrogen atoms, NOR and NNHSO2R, where R is hydrogen, C1-C10-alkyl, aryl or C7-C20-aralkyl, R4 is hydrogen or halogen, and moreover either: R6a, R6b together form methylene or 1,2-ethanediyl or R6a is hydrogen and R6b is selected from the group comprising hydrogen, C1-C10-alkyl, C2-C10-alkenyl or C2-C10-alkynyl, and R7 is selected from the group comprising hydrogen, C1-C10-alkyl, C3-C6-cycloalkyl, C2-C10-alkenyl or C2-C10-alkynyl, or: R6a is hydrogen and R6b and R7, together, denote a bond, an oxygen or form methylene, R18 represents hydrogen or C1-C3-alkyl and in addition include their solvates, hydrates, stereoisomers and salts.

Abstract: The present invention is based on the discovery of polyclonal IgG's ability to promote Schwann cell maturation, differentiation, and myelin production. Methods for treating non-idiopathic, demyelinating peripheral neuropathies in mammals, where the neuropathy is not immune-mediated or infection-mediated, through the administration of polyclonal IgG are provided. Types of demyelinating peripheral neuropathies treatable with the present invention include peripheral nerve trauma and toxin-induced peripheral neuropathies. Alternatively, a composition of polyclonal IgGs can be applied directly to a peripheral nerve cell to induce maturation, differentiation into a myelinating state, and myelin expression or promote cell survival.

Abstract: A method for encoding high dynamic range (HDR) images involves providing a lower dynamic range (LDR) image, generating a prediction function for estimating the values for pixels in the HDR image based on the values of corresponding pixels in the LDR image, and obtaining a residual frame based on differences between the pixel values of the HDR image and estimated pixel values. The LDR image, prediction function and residual frame can all be encoded in data from which either the LDR image of HDR image can be recreated.

Abstract: A validatable method for determining a photochemically effective dose for inactivating pathogens in a fluid sample is described herein. In particular, the instant invention covers methods for determining a photochemically effective dose sufficient to inactivate pathogens in a biological sample while leaving biologically active substances of interest unaffected. A batch irradiation reactor effective for inactivating pathogens in biological samples is also described.

Abstract: Apparatus and method for the defined intermediate storage of produced articles of the same type but different size and for the simultaneous composition of consignments of said articles, having the following features: a) a delivery path (3) for the continuous conveying of the produced products into the region of stacking robots (7), b) a multiplicity of transport vehicles (9) for transporting stacking pallets and order-picking pallets (6), c) a multiplicity of storing positions (10) for stacking pallets, d) one or more stacking robots (5) for filling order-picking pallets (6), e) a plurality of induction lines (8) for power supply and control of the transport vehicles (9).

Abstract: The embodiments relate to methods for measurement of RF excitation pulses by a magnetic resonance device including the following acts: (1) sending of an RF excitation pulse by a radio-frequency system of the magnetic resonance device, (2) triggering of a receive event for capturing the RF excitation pulse by the control device of the magnetic resonance device, and (3) capturing of the sent RF excitation pulse in the form of excitation data by the radio frequency system. In certain embodiments, the excitation data is used for checking process execution sequences.

Abstract: A process for the manufacture of a dental implant restoration system including an abutment for attaching a dental prosthesis within a patient's mouth. The abutment is a single unit structure fabricated of a ceramic material, multicolored throughout to match the color of the dental prosthesis, the surrounding dentition and the surrounding gingival tissue.

Abstract: In a method to determine a B0 field map describing the local deviation of a nominal Larmor frequency of a magnetic resonance apparatus, wherein magnetic resonance data are acquired in measurements implemented at two different echo times whose difference forms a dephasing time after an excitation at at least two different dephasing times, and a phase change to be used to determine the B0 field map is determined from a difference of phases measured at different echo times, the phase changes of different dephasing times are evaluated to at least partially reduce an ambiguity due to a Nyquist phase wrapping, by using dephasing times that result as a quotient or, given the use of only two dephasing times, as a product, of a base time and a respective prime number from a group including at least two different prime numbers that are greater than one, and wherein the group is selected depending on a desired dynamic range of the B0 field map and/or a maximum tolerated measurement error for the measurements.

Abstract: A dispensing head (103) for closing a vessel, mainly a tube or a vial, includes an outlet opening (135) and a hinged cap (104) for closing the opening (135) of the dispensing head. The dispensing head (103) and the hinged cap (104) are made of a single piece. The hinged cap (104) is molded over the dispensing head (103). The cap (104) can be secured onto the head (103) by anchoring even when the materials are not compatible.