Abstract: Described is a medicament delivery device comprising a housing having a distal end adapted to engage a removable needle assembly, a dosing mechanism coupled to the housing, and a sleeve coupled to the housing and having a distal end with one or more projections. Movement of the dosing mechanism causes axial translation of the sleeve relative to the housing and causes the one or more projections to extend from a retracted position relative to the housing beyond the distal end of the housing to disengage the removable needle assembly from the housing.

Abstract: The present invention concerns a solution and methods to reduce, treat and/or prevent oxidative stress and cell activation. According to the invention the solution gives rise to the following concentrations of constituents within a blood flow of 0.1-18 mM N-acetyl-cysteine, optionally of 0.01-0.21 mM vitamin C, optionally of 2-26 mM gluconic acid and optionally of 0.01-5 mM glutathione. According to the invention the methods comprises adding a solution according to the invention in an extracorporeal setting through the membrane by adding the solution to the dialysis fluid, or by infusion of a solution according to the invention, either by bolus injection, continuous injection or a combination thereof.