Abstract: The present invention relates to novel protein pores and their uses in analyte detection and characterisation. The invention particularly relates to an isolated pore complex formed by a CsgG-like pore and a modified CsgF peptide, or a homologue or mutant thereof, thereby incorporating an additional channel constriction or reader head in the nanopore. The invention further relates to a transmembrane pore complex and methods for production of the pore complex and for use in molecular sensing and nucleic acid sequencing applications.

Abstract: An integrated circuit (IC) design includes configurable circuits arranged in a mesh structure to facilitate routing of signals between different platforms or logic blocks within the design. Each configurable circuit has a semiconductor element with input and output terminals in a first semiconductor layer, input/output (I/O) ports corresponding to directions of the mesh structure in a second semiconductor layer, configurable input vias to allow a signal traveling in a first direction to be received, and configurable output vias that allow an output signal to be output from the configurable circuit in a second direction.

Abstract: A method and system for performing power leakage reduction for an integrated circuit (IC) in a Virtual Multi-mode Multi-corner set up. Multiple view of the IC design data are analyzed in parallel to determine which low threshold voltage cells (LTVC) may be replaced with high threshold voltage cells (HVTC). A second analysis is performed that combines the analyses of each of the analyzed views and the IC design data is updated, where all of the LTVCs having positive slack time in all of the plurality of views are replaced with HTVCs.