Abstract: The present invention provides piperazine derivatives of formula (I) as well as pharmaceutically acceptable salts and esters thereof, wherein R1 to R5 have the significance given in the description. They can be used for the treatment of obesity.

Abstract: The present invention provides piperazine derivatives in accordance with formula (I) as well as salts, hydrates and esters thereof. The substituent designations are as provided in the specification. The compounds of the present invention can be used in the treatment of type II diabetes or obesity.

Abstract: In a piezoelectric drive comprising clamping piezo packets which are adjacently arranged, under compressive pre-stress, between a reference part and an output part, the reference part is connected to the clamping piezo packets by means of a “semi-rigid” bridging plate, which adapts in a flexible manner to differences in stack height of the piezo packets, in a static state but remains essentially rigid in a dynamic state, that is, at the operating frequency of the drive.

Abstract: The disclosure is for a film coating which yields increased life for optical media molds and the method and apparatus for making such a film. The film is a carbon nitride layer of 0.5 to 5.0 microns thickness with 2% to 45% nitrogen coated on an underlayer. One method of making the carbon nitride film is by the use of a pulsed carbon arc to generate a carbon plasma while injecting nitrogen into the vacuum chamber in which the arc is created. Another method is to generate a radio frequency plasma in a vacuum chamber into which acetylene and nitrogen gas are injected. The carbon nitride is formed by the combination of nitrogen with the carbon from the acetylene.

Abstract: The present invention is directed to 1,2,3,4,10,10a,-hexahydro-pyrazino[1,2-a]indole derivatives as well as pharmaceutically acceptable salts, solvates and esters thereof, wherein R1 to R8 have the significance given in claim 1 be used in the form of pharmaceutical preparations for the treatment or prevention of disorders of the central nervous system, damage to the central nervous system, cardiovascular disorders, gastrointestinal disorders, diabetes insipidus, obesity and sleep apnea.

Abstract: The present invention relates to compounds of formula (I) 1

Abstract: The present invention is a chemical compound of formula (I) or a pharmaceutically acceptable salt, solvate and ester thereof, wherein R1 to R4 and n are as defined in the specification. A compound of formula 1 is useful as a pharmaceutical composition for the treatment or prevention of disorders of the central nervous system, cardiovascular disorders, gastrointestinal disorders, diabetes, obesity and sleep apnoea.

Abstract: The invention is a compact disc manufacturing mold which permits the mold to be used to produce a variety of non-standard sizes and shapes. A replaceable flat cavity ring which fits between the conventional mold pieces encloses the outer boundary of the disc and has an inner shape which defines the non-standard disc shape. The cavity ring includes a cylindrical projection extending from its surface which is in contact with the face of the mold piece. The extension is inserted into a groove in the mold face and is locked into the mold by threaded plugs screwed through the cylindrical sides of the mold piece.

Abstract: The disclosure is for a film coating which yields increased life for optical media molds and the method and apparatus for making such a film. The film is a carbon nitride layer of 0.5 to 5.0 microns thickness with 2% to 45% nitrogen coated on an underlayer. One method of making the carbon nitride film is by the use of a pulsed carbon arc to generate a carbon plasma while injecting nitrogen into the vacuum chamber in which the arc is created. Another method is to generate a radio frequency plasma in a vacuum chamber into which acetylene and nitrogen gas are injected. The carbon nitride is formed by the combination of nitrogen with the carbon from the acetylene.

Abstract: The invention is a compact disc manufacturing mold which permits the mold to be used to produce a variety of non-standard sizes and shapes. A replaceable flat cavity ring which fits between the conventional mold pieces encloses the outer boundary of the disc and has an inner shape which defines the non-standard disc shape. The cavity ring includes a cylindrical projection extending from its surface which is in contact with the face of the mold piece. The extension is inserted into a groove in the mold face and is locked into the mold by threaded plugs screwed through the cylindrical sides of the mold piece.

Abstract: The disclosure is for an improved film coating useable on optical media molds and the apparatus for and method of making such a film. The film is a diamond-like carbon layer of 0.3 to 3.0 microns coated on a titanium underlayer of 0.1 to 1.0 microns. The method of making the diamond-like carbon film is to deposit a defect free underlayer coating on to the steel substrate of the mold using an electron beam coating apparatus that has a hollow cathode electron beam generator and a rotating crucible containing the coating material. The diamond-like carbon film is then produced on top of the underlayer coating.

Abstract: Piperazine derivatives, as well as pharmaceutically acceptable salts, solvates and esters thereof, can be used in the form of pharmaceutical preparations for the treatment or prevention of disorders of the central nervous system, damage to the central nervous system, cardiovascular disorders, gastrointestinal disorders, diabetes insipidus, type II diabetes, obesity and sleep apnoea.

Abstract: The present invention is a chemical compound of formula (I) 1

Abstract: The apparatus is a hub bushing, called a gate insert, for an optical disc mold in which a thermally conductive but soft metal base structure is coated with a thin film physical vapor deposition or chemical vapor deposition coating which furnishes an extremely hard coating to protect the surfaces from wear. The base structure material of the gate insert is copper, aluminum, or a copper or aluminum based alloy, and typical materials used for the physical vapor deposition or chemical vapor deposition coating are titanium nitride, titanium carbide, or titanium carbonitride. Since the coating is only a few micrometers thick it has virtually no affect on the excellent thermal conductivity of the base structure, and the high thermal conductivity of the gate insert prevents quality degradation in the optical discs produced by the mold because the mold surfaces are prevented from having too great a difference in temperatures.

Abstract: The present invention is directed to 1,2,3,4,10,10a,-hexahydropyrazino[1,2-a] indole derivatives as well as pharmaceutically acceptable salts, solvates and esters thereof, wherein R1 to R8 have the significance given in claim 1 be used in the form of pharmaceutical preparations for the treatment or prevention of disorders of the central nervous system, damage to the central nervous system, cardiovascular disorders, gastrointestinal disorders, diabetes insipidus, obesity and sleep apnea.

Abstract: A key for a keyboard consisting of a base part (1) with a recess (7), an intermediate part (2), a key head (3) and an elastic return part (4). The cylindrical intermediate part (2) is arranged between the bottom part (14) of the key head (3) and the recess (7), with the intermediate part (2) moving into the recess (7) when the key head (3) is pressed. The intermediate part (2) is in a screw-like engagement with the bottom part (14) of the key head (3) and with the recess (7) in each case, with the one engagement running in the opposite direction to the other engagement.

Abstract: In a method and an apparatus for eliminating noise generated by a piezo actuator drive which includes in a housing a drive member, a drive shoe disposed adjacent the drive member, vibrating actuators forming drive elements and being connected to the drive shoe for engaging the drive shoe with the drive member and moving the drive shoe for driving the drive member, at least one additional actuator is disposed in the housing and operated at a frequency which is phase shifted with respect to at least the clamping actuators so as to cancel the noise waves generated during operation of the apparatus.

Abstract: A process for stabilizing a copolymer of maleic acid or maleic anhydride and vinyl alkyl ethers against a reduction in molecular weight in aqueous solution or in the solution of an organic solvent by adding 0.001 to 10% by weight, based on the copolymer, of a reducing agent, a tert-butyl-containing phenol or a mixture thereof.

Abstract: Compounds of formula (I) ##STR1## wherein R.sup.1 is hydrogen, lower alkyl, aralkyl, cycloalkyl, R.sup.3 CO-- or --C(R.sup.4 R.sup.5)CO.sub.2 R.sup.6 ; where R.sup.4 and R.sup.5 are each independently hydrogen or lower alkyl, or R.sup.4 and R.sup.5 taken together with the carbon atom to which they are attached form a cycloalkyl group; R.sup.3 is hydrogen or lower alkyl and R.sup.6 is hydrogen, lower alkyl, lower alkenyl or a carboxylic acid protecting group;R.sup.2 is isobutyl, 2,2-dimethyl-propyl or cyclohexyl-methyl;n is 0, 1 or 2;X is CH or N;as well as readily hydrolyzable esters thereof, pharmaceutically acceptable salts of said compounds and hydrates of the compounds of formula I and of their esters and salts are disclosed. These compounds have valuable antibacterial activity.

Abstract: The present invention relates to compounds of formula I ##STR1## wherein R.sup.1 is a group selected from 2-, 3-, and 4-hydroxyphenyl, 3-nitrophenyl, and 3-fluoro-4-hydroxyphenyl; as well as readily hydroyzable esters thereof, pharmaceutically acceptable salts of said compounds and hydrates of the compounds of formula I and of their esters and salts.