Patents by Inventor Hans Rudolf Muller

Hans Rudolf Muller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7816525
    Abstract: Process for the preparation of tetrahydropterin and tetrahydropterin derivatives by hydrogenating pterin and pterin derivatives with hydrogen in the presence of a hydrogenating catalyst, in which the hydrogenation is carried out in a polar reaction medium and metal complexes that are soluble in the reaction medium are employed as the hydrogenation catalysts. The process is suited to the hydrogenation, particularly asymmetric hydrogenation, of folic acid, folic acid salts, folic acid esters, folic acid ester salts or dihydroforms thereof, with the proviso that in the event of using folic acid, carboxylic acid salts thereof or dihydroforms thereof the reaction medium is aqueous, and in the event of using folic acid esters, folic acid ester salts or dihydroforms thereof the reaction medium is an alcohol. The process opens up straightforward access to achiral and chiral pterin derivatives.
    Type: Grant
    Filed: July 12, 2000
    Date of Patent: October 19, 2010
    Assignee: Merck & Cie
    Inventors: Hans Rudolf Muller, Rudolf Moser, Viola Groehn, Benoit Pugin
  • Publication number: 20080306263
    Abstract: Process for the preparation of tetrahydropterin and tetrahydropterin derivatives by hydrogenating pterin and pterin derivatives with hydrogen in the presence of a hydrogenating catalyst, in which the hydrogenation is carried out in a polar reaction medium and metal complexes that are soluble in the reaction medium are employed as the hydrogenation catalysts. The process is suited to the hydrogenation, particularly asymmetric hydrogenation, of folic acid, folio acid salts, folio acid esters, folio acid ester salts or dihydroforms thereof, with the proviso that in the event of using folic acid, carboxylic acid salts thereof or dihydroforms thereof the reaction medium is aqueous, and in the event of using folic acid esters, folic acid ester salts or dihydroforms thereof the reaction medium is an alcohol. The process opens up straightforward access to achiral and chiral pterin derivatives.
    Type: Application
    Filed: August 13, 2008
    Publication date: December 11, 2008
    Inventors: Hans Rudolf MULLER, Rudolf MOSER, Viola GROEHN, Benoit PUGIN
  • Patent number: 6858731
    Abstract: A process for preparing and concentrating (6S,?S) or (6S,?R) tetrahydrofolic acid ester salts and (6S,?S) or (6S,?R) tetrahydrofolic acid, characterized by preparing or dissolving equimolar or concentrated mixtures of diastereomers of addition salts of tetrahydrofolic acid esters with aromatic sulphonic acids in organic solvents, followed by crystallizing them at least once, and then if applicable hydrolyzing the crystallizate to produce (6S,?S) or (6S,?R) tetrahydrofolic acid, crystallizing the latter as a free acid or isolating it in the form of a salt.
    Type: Grant
    Filed: July 12, 2000
    Date of Patent: February 22, 2005
    Assignee: EPROVA AG
    Inventors: Hans Rudolf Muller, Rudolf Moser, Viola Groehn
  • Patent number: 6849735
    Abstract: An improved method of synthesis of a 9-substituted hypoxanthine derivative comprises the steps of: (1) reacting aminocyanacetamide with triethyl orthoformate to form an imidoester derivative of aminocyanacetamide; (2) forming a compound having a reactive amino group on a hydrocarbyl moiety, the hydrocarbyl moiety being linked through an amide group to a physiologically active moiety or an esterified derivative of a physiologically active moiety including therein an esterified benzoyl group; (3) reacting the imidoester with the compound having the reactive amino group on the hydrocarbyl moiety to form a derivative of aminoimidazole-4-carboxamide substituted at the 1-position with a hydrocarbyl moiety linked through an amide group to a physiologically active moiety including therein an optionally esterified benzoyl group; (4) forming the six-membered heterocyclic ring of the purine moiety of the hypoxanthine by reacting the derivative of 5-aminoimidazole-4-carboxamide formed in step (3) with triethyl orthoforma
    Type: Grant
    Filed: June 23, 2000
    Date of Patent: February 1, 2005
    Assignee: Merck Eprova AG
    Inventors: Alvin J. Glasky, Heinrich Bollinger, Hans Rudolf Müller
  • Patent number: 6596721
    Abstract: Pure and extremely stable crystalline (6R)-tetrahydrofolic acids, absolutely inert even when exposed to air and elevated temperature without stabilizers being added, are prepared by a crystallization process at a pH of ≧2.
    Type: Grant
    Filed: January 8, 2001
    Date of Patent: July 22, 2003
    Assignee: Eprova AG
    Inventors: Hans Rudolf Müller, Martin Ulmann, Rudolf Moser, Thomas Ammann
  • Patent number: 6407237
    Abstract: The bifunctional compound N-4-carboxyphenyl-3-(6-oxohydropurin-9-yl) propanamide monopotassium salt occurs in a number of crystal forms which differ in their stability. Of these forms, the most stable is designated Type I, which is a monopotassium salt monohydrate in which the water is held as water of crystallization. Other crystalline forms, designated Type II and Type III, convert to Type I. Methods are disclosed for the synthesis of Type I and for the conversion of Type II or Type III to Type I.
    Type: Grant
    Filed: February 16, 2000
    Date of Patent: June 18, 2002
    Assignee: NeoTherapeutics, Inc.
    Inventors: Alvin J. Glasky, Heinrich Bollinger, Hans Rudolf Müller
  • Patent number: 6292721
    Abstract: In order to provide the pilots with a display or a map of the terrain below the aircraft, a display is generated on a cockpit display, such as a weather radar, of the contours of the terrain below the aircraft. The terrain contour display is generated from aircraft position information, a terrain data base, and a terrain awareness envelope defined by awareness boundaries. Terrain contours are depicted with the highest terrain within the envelope colored red, high intermediate terrain contours in yellow with varying dot densities, low intermediate terrain contours in green with varying dot densities, and the lowest terrain in black. The green contours can be overwritten with a low density yellow based on a pre-caution envelope which extends certain of the awareness boundaries to provide notice to a pilot of upcoming cautions.
    Type: Grant
    Filed: June 23, 1998
    Date of Patent: September 18, 2001
    Assignee: Allied Signal Inc.
    Inventors: Kevin J Conner, Hans Rudolf Muller
  • Patent number: 6271374
    Abstract: Pure and extremely stable crystalline (6S)- and (6R)-tetrahydrofolic acids, absolutely inert even when exposed to air and elevated temperature without stabilizers being added, are prepared by a crystallization process at a pH of ≧3.5 for the preparation of crystalline (6S)-tetrahydrofolic acid and at a pH of ≧2 for the preparation of crystalline (6R)-tetrahydrofolic acid.
    Type: Grant
    Filed: January 26, 1998
    Date of Patent: August 7, 2001
    Assignee: Eprova AG
    Inventors: Hans Rudolf Müller, Martin Ulmann, Rudolf Moser, Thomas Ammann
  • Publication number: 20010002398
    Abstract: Pure and extremely stable crystalline (6S)- and (6R)-tetrahydrofolic acids, absolutely inert even when exposed to air and elevated temperature without stabilizers being added, are prepared by a crystallization process at a pH of ≧3.5 for the preparation of crystalline (6S)-tetrahydrofolic acid and at a pH of ≧2 for the preparation of crystalline (6R)-tetrahydrofolic acid.
    Type: Application
    Filed: January 8, 2001
    Publication date: May 31, 2001
    Applicant: EPROVA AKTIENGESELLSCGAFT
    Inventors: Hans Rudolf Muller, Martin Ulmann, Rudolf Moser, Thomas Ammann
  • Patent number: 6194600
    Abstract: With the present method, a process which can be employed industrially can be used for the first time for the direct production of aminocyanoacetamide. The method is based on the reaction of cyanoacetamide with nitrites to form nitrosocyanoacetamide at a pH of around 2 and on the subsequent catalytic hydrogenation of nitrosocyanoacetamide to form aminocyanoacetamide.
    Type: Grant
    Filed: August 26, 1999
    Date of Patent: February 27, 2001
    Assignee: Eprova A.G.
    Inventors: Hans Rudolf Müller, Heinrich Bollinger, Peter Schwaninger, Martin Kurz
  • Patent number: 6140507
    Abstract: The present invention relates to a novel process for the selective debenzylation of dibenzylbiotin, which is formed as an intermediate in the synthesis of biotin, but is usually not isolated.
    Type: Grant
    Filed: December 13, 1999
    Date of Patent: October 31, 2000
    Assignee: Merck Patent Gesellschaft mit
    Inventors: Ulrich Heywang, Heinrich Bollinger, Hans-Rudolf Muller
  • Patent number: 6011040
    Abstract: This invention relates to the use of tetrahydrofolates in natural stereoisomeric form for the production of a pharmaceutical preparation suitable for influencing the homocysteine level, particularly for assisting the remethylation of homocysteine. Clinical areas of application include all anomalies of the homocysteine level, particularly the prevention and treatment of cardiovascular diseases and the prevention of neural tube deficiencies.
    Type: Grant
    Filed: June 11, 1998
    Date of Patent: January 4, 2000
    Assignee: Eprova AG
    Inventors: Hans Rudolf Muller, Martin Ulmann, Rudolf Moser
  • Patent number: 5030350
    Abstract: A filter medium for cake-forming filtration processes is described, which is characterized in that a filter membrane is embedded on either side in a fabric structure, which assumes a mechanical protective function.
    Type: Grant
    Filed: August 25, 1989
    Date of Patent: July 9, 1991
    Assignee: Zuricher Beuteltuchfabrik Aktiengesellschraft
    Inventor: Hans-Rudolf Muller
  • Patent number: 4811693
    Abstract: An article adapted to be dispensed from aircraft onto large surface areas for the purpose of beneficially influencing the environment which employs a hollow casing having at least one opening whereby when at least one item for producing such influence is stored in the casing, the item will be released through the opening to the adjacent surface areas to initiate the influence on the environment after the casing is in landed position. At least one of the items is disposed in the casing. A structural arrangement is secured to the casing to prevent the casing when in landed position from being in direct contact with the surface area, thus shielding the item from the adverse influence of local weather.
    Type: Grant
    Filed: February 13, 1987
    Date of Patent: March 14, 1989
    Assignee: Zuricher Beuteltuchfabrik AG
    Inventor: Hans-Rudolf Muller
  • Patent number: 4785764
    Abstract: A casing in the form of cylindrical hollow body is terminated at one end by a base and is optionally provided with a hanger. The other end of the cylindrical hollow body is covered by a cover. The cover has a gauze arranged in a frame. The gauze meshes have a clearly defined cross-sectional surface. Useful organisms are placed in a protected manner in the hollow body and only those useful organisms having a desired size can pass through the gauze. The casing is treated by chemical or physical means so that it will remain intact and the organisms contained therein will be protected for a time period predetermined by such treatment. As the casing is made from non-toxic materials, its decomposition at the end of the intactness period does not adversely effect the environment.
    Type: Grant
    Filed: June 5, 1986
    Date of Patent: November 22, 1988
    Assignee: Zucher Beuteltuchfabrik AG
    Inventor: Hans-Rudolf Muller
  • Patent number: 4578192
    Abstract: The invention relates to a filter cloth for disk filters with in particular sector-shaped filter cells from a filter cloth. Into this filter cloth are directly integrated reinforcements in the form of U-shaped clips, where they are fixed in seams or hollow seams or loops.
    Type: Grant
    Filed: August 10, 1984
    Date of Patent: March 25, 1986
    Inventor: Hans-Rudolf Muller
  • Patent number: 4537714
    Abstract: The invention relates to a selective process for the preparation of N-L-.alpha.-aspartyl-L-phenylalanine-1-lower alkyl ester which comprises:A.
    Type: Grant
    Filed: July 7, 1983
    Date of Patent: August 27, 1985
    Assignee: Eprova Ag Forschungsinstitut
    Inventors: Hans-Rudolf Muller, Heinrich Bollinger
  • Patent number: 4242145
    Abstract: A process for the simultaneous production of fructose and of gluconic acid from glucose-fructose mixtures and/or from invert sugar by the selective oxidation of the glucose proportion, wherein oxygen and/or air, activated by noble metal catalysts, are utilized as the oxidizing agents; the oxidation is conducted in a pH range of about 8 to 10; and the oxidation is terminated after the formation of 1 equivalent of carboxylic acid per mole of glucose employed.The thus-obtained gluconic acid can subsequently be separated from the unchanged fructose in a simple way and practically quantitatively, and can be isolated as the salt.
    Type: Grant
    Filed: February 21, 1979
    Date of Patent: December 30, 1980
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Hans-Rudolf Muller, Werner Kundig, Alfred Hedinger
  • Patent number: 4095271
    Abstract: In order to provide a more accurate representation of aircraft pitch attitude for use in aircraft head up display devices, a circuit for generating a computed pitch signal responds to a longitudinal accelerometer and a vertical gyroscope within the aircraft wherein the computed pitch signal is generated by adding to the gyro pitch signal a correction factor computed by subtracting the value of the computed pitch signal from an inertial pitch signal derived from the longitudinal accelerometer. In order to compensate for the effects of aircraft acceleration on the longitudinal accelerometer signal, a computed acceleration signal derived from the difference between the longitudinal accelerometer signal and the gyro pitch signal is subtracted from the longitudinal accelerometer to generate the inertial pitch signal.
    Type: Grant
    Filed: April 20, 1977
    Date of Patent: June 13, 1978
    Assignee: Sundstrand Data Control, Inc.
    Inventor: Hans Rudolf Muller
  • Patent number: 4057782
    Abstract: An aircraft instrument with a reflective screen on which the pilot views a collimated head up display of flight guidance information against a background of the outside world, for low altitude maneuvers. The guidance information includes a pitch stabilized reference indicia and a flight path indicia. The pitch reference and flight path indicia are positioned on the screen in accordance with aircraft operating parameters and pilot inputs to provide for a flare maneuver to touchdown or to direct the pilot in a path parallel with the surface of the ground, as for ejecting cargo.
    Type: Grant
    Filed: April 5, 1976
    Date of Patent: November 8, 1977
    Assignee: Sundstrand Data Control, Inc.
    Inventor: Hans Rudolf Muller