Patents by Inventor Hans Schreiber
Hans Schreiber has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220047631Abstract: The disclosure provides Tn epitope-specific chimeric antigen receptors and scFvs, including soluble scFvs and multimeric scFvs, as well as methods of identifying cancer subjects and cancer subject sub-populations amenable to anti-Tn immunotherapy and methods of treating cancer.Type: ApplicationFiled: September 11, 2019Publication date: February 17, 2022Applicants: The University of Chicago, The Board of Trustees of the University of IllinoisInventors: Hans SCHREIBER, David KRANZ, Karin SCHREIBER, Yanran HE, Preeti SHARMA
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Patent number: 10189908Abstract: Disclosed are binding proteins, or fragments thereof, that specifically binds to a cancer-specific glycosylation variant of a protein and to a second epitope on the same protein, to a different protein presented on the same cell, or to a different protein presented on a different cell, such as an encoded polypeptide binding to both a cancer cell and an activated T cell. Also disclosed are polynucleotides encoding such binding proteins, including polynucleotides comprising codon-optimized coding regions and polynucleotides comprising coding regions that are not codon-optimized for expression in a particular host cell. Also disclosed are methods of making the encoded polypeptide and methods of using the polypeptide to treat, prevent or ameliorate the symptom of a disease such as cancer.Type: GrantFiled: February 5, 2015Date of Patent: January 29, 2019Assignee: THE UNIVERSITY OF CHICAGOInventors: Hans Schreiber, Christian Idel, Boris Engels
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Publication number: 20170166652Abstract: Disclosed are binding proteins, or fragments thereof, that specifically binds to a cancer-specific glycosylation variant of a protein and to a second epitope on the same protein, to a different protein presented on the same cell, or to a different protein presented on a different cell, such as an encoded polypeptide binding to both a cancer cell and an activated T cell. Also disclosed are polynucleotides encoding such binding proteins, including polynucleotides comprising codon-optimized coding regions and polynucleotides comprising coding regions that are not codon-optimized for expression in a particular host cell. Also disclosed are methods of making the encoded polypeptide and methods of using the polypeptide to treat, prevent or ameliorate the symptom of a disease such as cancer.Type: ApplicationFiled: February 5, 2015Publication date: June 15, 2017Applicant: THE UNIVERSITY OF CHICAGOInventors: Hans Schreiber, Christian Idel, Boris Engels
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Publication number: 20170145108Abstract: Disclosed are binding proteins, or fragments thereof, that specifically binds to a cancer-specific glycosylation variant of a protein and to a second epitope on the same protein, to a different protein presented on the same cell, or to a different protein presented on a different cell, such as an encoded polypeptide binding to both a cancer cell and an activated T cell. Also disclosed are polynucleotides encoding such binding proteins, including polynucleotides comprising codon-optimized coding regions and polynucleotides comprising coding regions that are not codon-optimized for expression in a particular host cell. Also disclosed are methods of making the encoded polypeptide and methods of using the polypeptide to treat, prevent or ameliorate the symptom of a disease such as cancer.Type: ApplicationFiled: February 5, 2015Publication date: May 25, 2017Inventors: Hans Schreiber, Christian Idel, Boris Engels
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Publication number: 20150315247Abstract: The invention provides a methodology to use cancer vaccination to overcome tumor resistance to immunostimulatory antibodies. Our cancer vaccination approach relies on targeting mutant tumor-specific peptides that have high affinity for the major histocompatibility complex. Treatment with bacteria expressing high affinity tumor-specific peptides combined with anti-PD-L1 monoclonal antibody can eradicate long-established tumors resistant to anti-PD-L1 and anti-CTLA-4 alone. In addition, we discovered that adoptive transfer of T cells with this same vaccine-generated T cell receptor specificity can also eradicate long-established tumors. These results demonstrate that cancer vaccination approaches should target peptides with high peptide-MHC affinity to (i) overcome tumor resistance to immunostimulatory antibodies and (ii) identify T cell receptors that can be used successfully for adoptive T cell transfer.Type: ApplicationFiled: May 4, 2014Publication date: November 5, 2015Inventors: David Charles Binder, Hans Schreiber
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Patent number: 7384673Abstract: A convoluted boot for constant velocity joints and a constant velocity joint lubricant for use in such a convoluted boot. An additive which is added to the constant velocity joint lubricant and/or to the convoluted boot material is provided. The additive comprises amide waxes and also may include hydrocarbon oils. Use is made, in particular, of monoamides and/or diamides of carboxylic acids with 8 to 50 carbon atoms to form, by diffusion, a lubricating film on the surface of a convoluted boot. Furthermore, oleic acid amide and/or ethylenediamine distearate result in a particularly early formation of a lubricating film on the outer boot surface and thus to a long-term prevention of noise.Type: GrantFiled: December 23, 2002Date of Patent: June 10, 2008Assignee: GKN Automotive GmbHInventors: Herbert Konegen, Hans Schreiber, Lothar Gasper
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Patent number: 6743482Abstract: The invention relates to an impregnating agent for a convoluted boot consisting of a thermplastic or elastomer material and used for covering the chamber of a joint, especially a rotating joint subjected to large articulation angles, which joint chamber is filled with a lubricant, said convoluted boot comprising a plurality of folds and two end collars, with the surfaces of the convoluted boot wall contacting one another when the joint is subjected to large articulation angles. It is the object of the invention to reduce the wear and eliminate squeaking symptoms of convoluted boots treated with the inventive impregnating agent. In accordance with the invention, the objective is achieved in that the impregnating agent contains a carrier fluid, an oil dissolved in the carrier fluid and having a molecular weight of >200, and a wetting agent which is soluble in oil and which reduces the surface tension of the oil.Type: GrantFiled: March 24, 2003Date of Patent: June 1, 2004Assignee: GKN Automotive AGInventors: Thomas Schmidt, Joachim Wette, Thomas Schafferus, Herbert Konegen, Hans Schreiber
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Publication number: 20030143353Abstract: A convoluted boot for constant velocity joints and a constant velocity joint lubricant for use in such a convoluted boot. An additive which is added to the constant velocity joint lubricant and/or to the convoluted boot material is provided. The additive comprises amide waxes and also may include hydrocarbon oils. Use is made, in particular, of monoamides and/or diamides of carboxylic acids with 8 to 50 carbon atoms to form, by diffusion, a lubricating film on the surface of a convoluted boot. Furthermore, oleic acid amide and/or ethylenediamine distearate result in a particularly early formation of a lubricating film on the outer boot surface and thus to a long-term prevention of noise.Type: ApplicationFiled: December 23, 2002Publication date: July 31, 2003Inventors: Herbert Konegen, Hans Schreiber, Lothar Gasper
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Publication number: 20030143355Abstract: The invention relates to an impregnating agent for a convoluted boot consisting of a thermplastic or elastomer material and used for covering the chamber of a joint, especially a rotating joint subjected to large articulation angles, which joint chamber is filled with a lubricant, said convoluted boot comprising a plurality of folds and two end collars, with the surfaces of the convoluted boot wall contacting one another when the joint is subjected to large articulation angles. It is the object of the invention to reduce the wear and eliminate squeaking symptoms of convoluted boots treated with the inventive impregnating agent. In accordance with the invention, the objective is achieved in that the impregnating agent contains a carrier fluid, an oil dissolved in the carrier fluid and having a molecular weight of>200, and a wetting agent which is soluble in oil and which reduces the surface tension of the oil.Type: ApplicationFiled: March 24, 2003Publication date: July 31, 2003Inventors: Thomas Schmidt, Joachim Wette, Thomas Schafferus, Herbert Konegan, Hans Schreiber
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Patent number: 6569021Abstract: The invention relates to an impregnating agent for a convoluted boot consisting of a thermplastic or elastomer material and used for covering the chamber of a joint, especially a rotating joint subjected to large articulation angles, which joint chamber is filled with a lubricant, said convoluted boot comprising a plurality of folds and two end collars, with the surfaces of the convoluted boot wall contacting one another when the joint is subjected to large articulation angles. It is the object of the invention to reduce the wear and eliminate squeaking symptoms of convoluted boots treated with the inventive impregnating agent. In accordance with the invention, the objective is achieved in that the impregnating agent contains a carrier fluid, an oil dissolved in the carrier fluid and having a molecular weight of >200, and a wetting agent which is soluble in oil and which reduces the surface tension of the oil.Type: GrantFiled: July 17, 2000Date of Patent: May 27, 2003Assignee: GKN Automotive AGInventors: Thomas Schmidt, Joachim Wette, Thomas Schafferus, Herbert Konegen, Hans Schreiber
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Patent number: 5725432Abstract: A constant velocity universal ball joint (1) has an outer part (2), an inner part (6) received therein, and a cage (11) arranged between the outer part (2) and inner part (3) to guide balls (17) which serves to transmit torque between the outer part (2) and inner part (6). The balls (17) are guided between parallel window faces (15, 16) of the cage (11). To improve the service life values and the running-in conditions of the joint, balls (17) are used whose surface is ground and have a defined roughness. Thus, in the case of tolerance errors, the window faces (15, 16) are worked off to such an extent as to achieve identical load bearing conditions at the balls.Type: GrantFiled: September 23, 1996Date of Patent: March 10, 1998Assignee: GKN Automotive AGInventors: Herbert Konegen, Peter Seigert, Hans Schreiber, Frank Tenhumberg
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Patent number: 5670461Abstract: Disclosed is a lubricating grease suitable for high temperature use, consisting essentially of 60 to 90% by weight of a base oil mixture comprising at least one mineral oil and at least one synthetic oil, 5 to 17% by weight of at least one urea compound as a thickener, wherein the at least one urea compound is a reaction product of at least one fatty amine and at least one isocyanate or at least one diisocyanate, 2 to 20% by weight of calcium complex grease, 1 to 4% by weight of molybdenum disulphide, 0.2 to 1% by weight of graphite powder, 0.2 to 1% by weight of polytetrafluoroethylene powder, 0.2 to 1% by weight of solid particles of at least one organo-molybdenum compound selected from a molybdenum dithiocarbamate and a molybdenum dithiophosphate, up to 2% by weight of a metal deactivator and up to 2% by weight of a corrosion inhibitor.Type: GrantFiled: August 15, 1995Date of Patent: September 23, 1997Assignee: GKN Automotive AGInventors: Hans Schreiber, Peter Seigert, Herbert Konegen, Wolfgang Hildebrandt
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Patent number: 5247217Abstract: In a safety system for a stepper-motor drive, a stepper motor for operating a throttle valve has poles with windings. Each pole winding is divided into part-windings, each of which is driven by a dedicated output stage. As a result, in the event of a failure of a part-winding or an output stage, it remains possible to control the stepper motor.Type: GrantFiled: May 27, 1992Date of Patent: September 21, 1993Assignee: Siemens AktiengesellschaftInventors: Ludwig Binnewies, Udo Frinzel, Hans Schreiber, Herbert Zimmer, Andreas Noichl, Manfred Trefalt, Roman Turba
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Patent number: 5190455Abstract: A method and apparatus for performing a head-related model incorporating for transferring a jaw model between articulators of different types. The apparatus for the head-related incorporation of jaw models includes an articulator base plate, a ground plate connected to the articulator base plate and a cylinder having a cylindrical cavity connected vertically to an upper surface of the ground plate. A piston is inserted in the cylindrical cavity. A carrier plate is connected to the end of the piston opposite the articulator base plate. A split cast plate is positioned on the carrier plate and exactly repositionable via magnetic connection between the split cast plate and the carrier plate. A fixation element is connected to the carrier plate. An articulator mounting plate is supported by and connected to the split cast plate via a hardened viscous medium.Type: GrantFiled: February 13, 1989Date of Patent: March 2, 1993Inventor: Hans Schreiber
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Patent number: 5085197Abstract: With the present tank ventilation system formed of a fuel tank, an active carbon filter, a control unit, a lambda probe, a tank ventilation valve and a flow sensor it is possible to recognize defects at the connecting lines and the ventilation valve immediately. For the recognition of the defect, a control unit is provided which examines the signals arriving from the lambda probe and from the flow sensor along with the outgoing tank ventilation control signals for unreasonable events. When a defect is recognized, the error signal is stored. A ceramic PTC resistor is preferably employed as the flow sensor.Type: GrantFiled: July 26, 1990Date of Patent: February 4, 1992Assignee: Siemens AktiengesellschaftInventors: Gerhard Mader, Hans Meixner, Hans Schreiber
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Patent number: 5016198Abstract: A type characteristic of a measurement transducer is stored in a type memory of an evaluator. Deviations of the type characteristic from the individual characteristic of the measurement transducer are defined by individual values which accompany the measurement transducer in a coding memory. A computer of the evaluator identifies the corresponding measured value for every electrical measured signal from the type characteristic and from the individual values.Type: GrantFiled: March 19, 1990Date of Patent: May 14, 1991Assignee: Siemens AktiengesellschaftInventor: Hans Schreiber
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Patent number: 4889486Abstract: A device for mounting for mounting jaw casts in an articulator, has a spatially adjustable cast plate, an articulator base plate, and wedges that can be moved longitudinally and transversely. The wedges can be rotated axially, and fixation elements can be moved like a sled in the inclination of the wedges. The fixation elements can be locked in a predetermined position by screwing in the inclination of the wedges, with the cast plate being pressed against the wedges and fixed.Type: GrantFiled: January 22, 1988Date of Patent: December 26, 1989Inventor: Hans Schreiber
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Patent number: 4846917Abstract: A method for producing and vulcanizing an inflatable hollow body from a double cloth having upper and lower plies with edges and pile yarns spacing the plies apart includes applying a respective gas-tight unvulcanized layer of rubber to each of the upper and lower piles of the double cloth. The edges of the upper and lower plies are joined with angle braces forming a hollow body. The hollow body is evacuated over a predetermined period of time and the hollow body is vulcanized in the evacuated state.Type: GrantFiled: September 16, 1987Date of Patent: July 11, 1989Assignee: Metzeler GmbHInventors: Volker Hartel, Gerhard Hoglinger, Hans Schreiber
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Patent number: 4823749Abstract: Device for controlling the intake air in an internal combustion engine. The control occurs via a throttle valve that is adjusted by a stepping motor and is directly secured on the shaft of the stepping motor thereof. The stepping motor is driven in fine step mode in order to be able to position the throttle value with great precision. In order to achieve a high speed of adjustment, a rough step mode is provided, whereby an extremely large, dynamic load angle can be respectively achieved during accelerating and decelerating independently of the operating parameters.Type: GrantFiled: March 23, 1988Date of Patent: April 25, 1989Assignee: Siemens AktiengesellschaftInventors: Manfred Eisenmann, Hans Schreiber
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Patent number: 4797611Abstract: The generator wheel is composed of a tooth part and of a marker part. The tooth part has a rotational axis and a coaxial tooth or toothed edge in the shape of a circular ring with teeth situated distributed over its circumference, some of said teeth being marker teeth which include a recess. The marker part is secured to the tooth part and contains sheet metal strips corresponding in number to the number of marker teeth, said sheet metal strips projecting into said recesses of the marker teeth. Marker part and tooth part are composed of materials having different eddy current losses.Type: GrantFiled: July 1, 1987Date of Patent: January 10, 1989Assignee: Siemens AktiengesellschaftInventor: Hans Schreiber