Patents by Inventor Hans Soderlund
Hans Soderlund has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9856296Abstract: The present invention provides mutant polypeptides useful as hypoallergens. More specifically the present invention provides mutant Bet v 1 proteins and the use of such polypeptides as hypoallergens for desensitizing against birch pollen allergies. Furthermore, the invention provides vaccine formulations comprising such polypeptides; the use of such formulations; and to methods of vaccination against birch pollen allergy.Type: GrantFiled: April 18, 2012Date of Patent: January 2, 2018Assignee: DESENTUM OYInventors: Kristiina Takkinen, Marja-Leena Laukkanen, Hans Söderlund, Sirpa Jylhä, Heidi Holkeri, Merja Niemi, Janne Jänis, Juha Rouvinen
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Patent number: 9416401Abstract: The invention is related to a method and test kits for quantitative determination of polynucleotide amounts present in a sample. The test kit comprises organized pools with polynucleotide probes having distinct sizes and optionally provided with tracer tags or primer tags. The probes are allowed to hybridize with affinity tagged analyte polynucleotides from the sample. The result is hybrids, which can be recovered on a separation aiding tool provided with the pair of the affinity tag. After the quantitative release of the probes, the probes are either directly recorded, or if primer tagged, they are amplified and optionally provided with a tracer tag before recording. The invention provides a sensitive and quantitative determination of the amount polynucleotides present in a cell or tissue sample and allows a quantitative assessment of variations in the amounts of polynucleotides as a response to inherent changes or due to external stimuli.Type: GrantFiled: January 10, 2002Date of Patent: August 16, 2016Assignee: VALTION TEKNILLINEN TUTKIMUSKESKUSInventors: Hans Söderlund, Kari Kataja, Marja Paloheimo, Marja Ilmen, Kristiina Takkinen
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Patent number: 9261511Abstract: The present invention relates to human IgE antibodies and derivatives thereof, which bind non-continuous planar allergenic epitope, such as in ?-lactoglobulin, with high affinity and specificity. The present invention also relates to processes for making and engineering such allergen binding monoclonal antibodies and to methods for using these antibodies and derivatives thereof in the field of immunodiagnostics and immunotherapy.Type: GrantFiled: January 29, 2008Date of Patent: February 16, 2016Assignee: DESENTUM OYInventors: Sirpa Jylhä, Merja Niemi, Juha Rouvinen, Marja-Leena Laukkanen, Kristiina Takkinen, Hans Söderlund, Soili Mäkinen-Kiljunen, Tari Haahtela
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Patent number: 8895292Abstract: A microfluidic chip device (MCD) and its use for performing miniaturized assays on magnetic microbeads (MMs) are described. The MCD is particularly useful for carrying out miniaturized transcript analysis by aiding affinity capturing (TRAC) assays, including PCR. The MCD comprises at least one reaction chamber with sealable liquid connections and at least one fluidic pillar filter in each chamber. The fluidic pillar filter comprises rods with spacings allowing MMs to pass. The sealable liquid connections feed liquid to the reaction chamber, wherein air bubbles are removed. The liquid stream contacts the MMs, which are manipulated with a magnetic rod. The liquid connections enable trapping of the MMs behind the pillar filters or in the channel, while the liquid is changed.Type: GrantFiled: April 9, 2009Date of Patent: November 25, 2014Assignee: Valtion Teknillinen TutkimuskeskusInventors: Hans Söderlund, Ari Hokkanen, Kari Kataja, Ingmar Stuns, Kai Kolari, Heli Siren, Stella Rovio, Reetta Satokari, Jan Rautio
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Patent number: 8877894Abstract: The present invention is related to field of allergic (hypersensitivity) diseases and provides a method for producing modified allergenic polypeptides for use in immunotherapies. In the method of the invention, said allergenic polypeptides are modified so that they are not capable to form transient dimers. The invention also provides modified ?-lactoglobulins for use in immunotherapy of milk allergy.Type: GrantFiled: June 18, 2009Date of Patent: November 4, 2014Assignee: Teknologian Tutkimuskeskus VTTInventors: Juha Rouvinen, Kristiina Takkinen, Merja Niemi, Sirpa Jylhä, Hans Söderlund, Marja-Leena Laukkanen
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Publication number: 20140044744Abstract: The present invention provides mutant polypeptides useful as hypoallergens. More specifically the present invention provides mutant Bet v 1 proteins and the use of such polypeptides as hypoallergens for desensitizing against birch pollen allergies. Furthermore, the invention provides vaccine formulations comprising such polypeptides; the use of such formulations; and to methods of vaccination against birch pollen allergy.Type: ApplicationFiled: April 18, 2012Publication date: February 13, 2014Applicant: TEKNOLOGIAN TUTKIMUSKESKUS VTTInventors: Kristiina Takkinen, Marja-Leena Laukkanen, Hans Söderlund, Sirpa Jylhä, Heidi Holkeri, Merja Niemi, Juha Rouvinen
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Publication number: 20140037663Abstract: The present invention provides mutant polypeptides useful as hypoallergens. More specifically the present invention provides mutant Bet v 1 proteins and the use of such polypeptides as hypoallergens for desensitizing against birch pollen allergies. Furthermore, the invention provides vaccine formulations comprising such polypeptides; the use of such formulations; and to methods of vaccination against birch pollen allergy.Type: ApplicationFiled: April 18, 2012Publication date: February 6, 2014Applicant: TEKNOLOGIAN TUTKIMUSKESKUS VTTInventors: Kristiina Takkinen, Marja-Leena Laukkanen, Hans Söderlund, Sirpa Jylhä, Heidi Holkeri, Merja Niemi, Janne Jänis, Juha Rouvinen
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Patent number: 8518653Abstract: A binding partner, especially an antibody fragment that specifically recognizes an antigen-antibody immune complex between anti-THC and THC (tetrahydrocannabinol), is disclosed. The binding partner facilitates a non-competitive homogenous immunoassay for detection of cannabis use. A test kit comprising the binding partner is also described. Preferably the immunoassay is applied for roadside testing of saliva from suspected drivers.Type: GrantFiled: June 5, 2009Date of Patent: August 27, 2013Assignee: Teknologian Tutkimuskeskus VTTInventors: Kristiina Takkinen, Hans Söderlund, Timo Pulli
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Patent number: 8476027Abstract: A binding partner, especially an antibody fragment that specifically recognizes an antigen-antibody immune complex between anti-THC and THC (tetrahydrocannabinol), is disclosed. The binding partner facilitates a non-competitive homogenous immunoassay for detection of cannabis use. A test kit comprising the binding partner is also described. Preferably the immunoassay is applied for roadside testing of saliva from suspected drivers.Type: GrantFiled: June 5, 2009Date of Patent: July 2, 2013Assignee: Teknologian Tutkimuskeskus VTTInventors: Kristiina Takkinen, Hans Söderlund, Timo Pulli
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Patent number: 8143388Abstract: The invention relates to a method and test kit for quantitative determination of the amounts or relative proportions of polynucleotides in a mixture. The invention enables assessment of dynamic variations in a mixed population of organisms using affinity aided solution hybridization. The test kit comprises organized pools of polynucleotide probes having approximately the same number of nucleotides, which are distinguishable using resolution enabling tags providing the probes with different sizes. The resolution enabling tags may simultaneously act as tracer, affinity or primer tags. The probes are allowed to hybridize with affinity tagged analyte polynucleotides. The result is hybrids, recoverable on separation aiding tools provided with counterparts of the affinity tag. After the quantitative release of the probes, the individual probes can be amplified and recorded.Type: GrantFiled: April 18, 2008Date of Patent: March 27, 2012Assignee: Valtion Teknillinen TutkimuskeskusInventors: Hans Söderlund, Reetta Satokari, Kari Kataja, Kristiina Takkinen
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Publication number: 20110104190Abstract: The present invention is related to field of allergic (hypersensitivity) diseases and provides a method for producing modified allergenic polypeptides for use in immunotherapies. In the method of the invention, said allergenic polypeptides are modified so that they are not capable to form transient dimers. The invention also provides modified ?-lactoglobulins for use in immunotherapy of milk allergy.Type: ApplicationFiled: June 18, 2009Publication date: May 5, 2011Applicant: TEKNOLOGIAN TUTKIMUSKESKUS VTTInventors: Juha Rouvinen, Kristiina Takkinen, Merja Niemi, Sirpa Jylhä, Hans Söderlund, Marja-Leena Laukkanen
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Publication number: 20110086364Abstract: A binding partner, especially an antibody fragment that specifically recognizes an antigen-antibody immune complex between anti-THC and THC (tetrahydrocannabinol), is disclosed. The binding partner facilitates a non-competitive homogenous immunoassay for detection of cannabis use. A test kit comprising the binding partner is also described. Preferably the immunoassay is applied for roadside testing of saliva from suspected drivers.Type: ApplicationFiled: June 5, 2009Publication date: April 14, 2011Applicant: TEKNOLOGIAN TUTKIMUSKESKUS VTTInventors: Kristiina Takkinen, Hans Söderlund, Timo Pulli
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Publication number: 20100311604Abstract: This invention relates to protein engineering technology. More particularly, the present invention relates to a method for preparing human IgE antibodies and derivatives thereof, which bind epitope structures that are weakly IgG or IgM immunoreactive.Type: ApplicationFiled: January 29, 2008Publication date: December 9, 2010Applicant: Valtion Teknillinen TutkimuskeskusInventors: Kristiina Takkinen, Juha Rouvinen, Merja Niemi, Sirpa Jylhä, Marja-Leena Laukkanen, Hans Söderlund
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Patent number: 7749712Abstract: A non-competitive immunoassay for small analytes, wherein the analyte is reacted with two binding partners. The first binding partner binds to the analyte to form a complex between the first binding partner and the analyte, and the second binding partner binds to the complex formed by the first binding partner and the analyte. The resulting complex formed between the analyte and the binding partners is detected. The binding partners are proteins, such as antibodies including antibody fragments.Type: GrantFiled: November 17, 2003Date of Patent: July 6, 2010Assignee: Valtion teknillinen tutkimuskeskusInventors: Timo Pulli, Matti Hoyhtya, Kristiina Takkinen, Hans Soderlund
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Publication number: 20100086552Abstract: The present invention relates to human IgE antibodies and derivatives thereof, which bind non-continuous planar allergenic epitope, such as in ?-lactoglobulin, with high affinity and specificity. The present invention also relates to processes for making and engineering such allergen binding monoclonal antibodies and to methods for using these antibodies and derivatives thereof in the field of immunodiagnostics and immunotherapy.Type: ApplicationFiled: January 29, 2008Publication date: April 8, 2010Applicant: Valtion Teknillinen TutkimuskeskusInventors: Sirpa Jylhä, Merja Niemi, Juha Rouvinen, Marja-Leena Laukkanen, Kristiina Takkinen, Hans Söderlund, Soili Mäkinen-Kiljunen, Tari Haahtela
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Publication number: 20090269767Abstract: A microfluidic chip device (MCD) and its use for performing miniaturized assays on magnetic microbeads (MMs) are described. The MCD is particularly useful for carrying out miniaturized transcript analysis by aiding affinity capturing (TRAC) assays, including PCR. The MCD comprises at least one reaction chamber with sealable liquid connections and at least one fluidic pillar filter in each chamber. The fluidic pillar filter comprises rods with spacings allowing MMs to pass. The sealable liquid connections feed liquid to the reaction chamber, wherein air bubbles are removed. The liquid stream contacts the MMs, which are manipulated with a magnetic rod. The liquid connections enable trapping of the MMs behind the pillar filters or in the channel, while the liquid is changed.Type: ApplicationFiled: April 9, 2009Publication date: October 29, 2009Applicant: c/o Valtion teknillinen tutkimuskeskusInventors: Hans SODERLUND, Ari Hokkanen, Kari Kataja, Ingmar Stuns, Kai Kolari, Heli Siren, Stella Rovio, Reetta Satokari, Jari Rautio
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Publication number: 20090011944Abstract: The present invention is related to a method for a simultaneous determination of the relative amounts of more than one target polynucleotide sequence and nucleotide variations in said targets. The method is carried out by separating and recording single-stranded probes, which have hybridized to the targets and which are determined and distinguished by their defined properties including size and optional detectable label. The probes are complementary to a region in the target that has a sequence being contiguous to the nucleotide variations to be determined. After being hybridized with affinity-tagged targets, the probes are attached to a solid support and purified. The target probe hybrids are elongated using enzyme-assisted elongations. The elongated probes are recorded after release from the solid supports and the amount of each of the targets and their nucleotide variations and the ratio of modified and modified target polynucleotide sequences are calculated from the recorded results.Type: ApplicationFiled: February 20, 2008Publication date: January 8, 2009Applicant: VALTION TEKNILLINEN TUTKIMUSKEKUSInventors: Hans SODERLUND, Jari Raitio
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Publication number: 20080233591Abstract: The invention relates to a method and test kit for quantitative determination of the amounts or relative proportions of polynucleotides in a mixture. The invention enables assessment of dynamic variations in a mixed population of organisms using affinity aided solution hybridization. The test kit comprises organized pools of polynucleotide probes having approximately the same number of nucleotides, which are distinguishable using resolution enabling tags providing the probes with different sizes. The resolution enabling tags may simultaneously act as tracer, affinity or primer tags. The probes are allowed to hybridize with affinity tagged analyte polynucleotides. The result is hybrids, recoverable on separation aiding tools provided with counterparts of the affinity tag. After the quantitative release of the probes, the individual probes can be amplified and recorded.Type: ApplicationFiled: April 18, 2008Publication date: September 25, 2008Inventors: Hans SODERLUND, Reetta Satokari, Kari Kataja, Kristiina Takkinen
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Patent number: 7361461Abstract: The invention relates to a method and test kit for quantitative determination of the amounts or relative proportions of polynucleotides in a mixture. The invention enables assessment of dynamic variations in a mixed population of organisms using affinity aided solution hybridization. The test kit comprises organized pools of polynucleotide probes having approximately the same number of nucleotides, which are distinguishable using resolution enabling tags providing the probes with different sizes. The resolution enabling tags may simultaneously act as tracer, affinity or primer tags. The probes are allowed to hybridize with affinity tagged analyte polynucleotides. The result is hybrids, recoverable on separation aiding tools provided with counterparts of the affinity tag. After the quantitative release of the probes, the individual probes can be amplified and recorded.Type: GrantFiled: July 4, 2003Date of Patent: April 22, 2008Assignee: Valtion Teknillinen TutkimuskeskusInventors: Hans Söderlund, Reetta Satokari, Kari Kataja, Kristiina Takkinen
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Publication number: 20070134757Abstract: This, invention relates to a method for cleaving proteins or peptides at a specific site. According to the invention an amino acid sequence is constructed at a predetermined cleavage site and the protein or peptide is allowed to react with free metal ions in a buffer. The buffer further comprises a reducing or oxidizing agent for enhancing the cleavage. The amino acids in the amino acid sequence are selected from the group comprising histidine, lysine, tryptophan, arginine, tyrosine, phenylalanine, and cysteine.Type: ApplicationFiled: July 8, 2004Publication date: June 14, 2007Applicant: Valtion Teknillinen TutkimuskeskusInventors: Markus Linder, Jussi Jantti, Hans Soderlund, Juho Helaja, Ari Koskinen