Abstract: The invention features methods, panels, cartridges, and systems for detecting pathogens and for diagnosing and treating diseases, including bacteremia and sepsis.

Abstract: The invention features methods panels, cartridges, and systems for detecting pathogens and for diagnosing and treating diseases, including bacteremia and sepsis.

Abstract: The disclosure generally relates to CCS sorbents, particularly for CO2/H2O displacement desorption process. The sorbent includes an aluminum oxide support and an alkali metal salt impregnated on the support, and a silicon modification of the sorbent to reduce water uptake by the sorbent and make it more hydrophobic. The silicon modification can be an organosilyl moiety added after the initial sorbent is complete, or a silica source added to the aluminum oxide structure, typically via impregnation. The sorbents demonstrate better H2O/CO2 ratios. Compositions and methods of making are disclosed.

Abstract: The invention features methods, systems, and panels for rapid detection of tick-borne pathogens in a sample (including Borrelia spp. such as B. burgdorferi, B. afzelii, and B. garinii) and for diagnosis and monitoring of tick-transmitted diseases, including Lyme disease, Rocky Mountain spotted fever, Q-fever, babesiosis, ehrlichiosis, tularemia, and anaplasmosis.

Abstract: The invention features methods, systems, and panels for rapid detection of tick-borne pathogens in a sample (including Borrelia spp. such as B. burgdorferi, B. afzelii, and B. garinii) and for diagnosis and monitoring of tick-transmitted diseases, including Lyme disease, Rocky Mountain spotted fever, Q-fever, babesiosis, ehrlichiosis, tularemia, and anaplasmosis.

Abstract: The disclosure generally relates to CCS sorbents, particularly for CO2/H2O displacement desorption process. The sorbents include an aluminum oxide support that includes two alkali metal salts impregnated on the support. The two alkali metals include a potassium metal salts and a second alkali metal salt which is not potassium. The second metal salt disrupts poisoning effects that degrade sorbent lifetime. The sorbents demonstrate improved CO2 loadings and better H2O/CO2 ratios, as well as improved stability. Compositions and methods of making are disclosed.

Abstract: The present disclosure provides fully integrated microfluidic systems to perform nucleic acid analysis. These processes include sample collection, nucleic acid extraction and purification, amplification, sequencing, and separation and detection. The present disclosure also provides optical detection systems and methods for separation and detection of biological molecules. In particular, the various aspects of the invention enable the simultaneous separation and detection of a plurality of biological molecules, typically fluorescent dye-labeled nucleic acids, within one or a plurality of microfluidic chambers or channels. The nucleic acids can be labeled with at least 6 dyes, each having a unique peak emission wavelength. The present systems and methods are particularly useful for DNA fragment sizing applications such as human identification by genetic fingerprinting and DNA sequencing applications such as clinical diagnostics.

Abstract: The disclosure generally relates to CCS sorbents, particularly for CO2/H2O displacement desorption process. The sorbents include an aluminum oxide support that includes alkali metal salts within the support, in the form of pseudo alkali aluminate. The sorbents also include alkali metal salt impregnated on the support. The sorbents demonstrate improved CO2 loadings and better H2O/CO2 ratios, as well as improved stability. Compositions and methods of making are disclosed.

Abstract: The invention features methods, systems, and cartridges for amplification of target nucleic acids in complex samples, for example, whole blood. The invention also features diagnostic and therapeutic methods based on amplification of target nucleic acids characteristic of pathogens present in complex samples containing cells and/or cell debris, for example, whole blood.

Abstract: Gas separation modules and methods for use including an integrated adsorbent and membrane. In certain refining applications, it is paramount to obtain high purity product gases. Adsorbent beds are effective at removing certain contaminants, such as CO2, from gas streams containing product and contaminant constituents to form a product-rich stream. The integrated membrane permits a further separation of products from any unadsorbed contaminant to produce a high purity product, such as hydrogen, stream. The gas separation modules described herein include stacked, radial, and spiral arrangements. Each modules includes a configuration of feed and cross-flow channels for the collection of contaminant gases and/or high purity product gases.

Abstract: Systems and methods are provided for combined cycle power generation while reducing or mitigating emissions during power generation. Recycled exhaust gas from a power generation combustion reaction can be separated using a swing adsorption process so as to generate a high purity CO2 stream while reducing/minimizing the energy required for the separation and without having to reduce the temperature of the exhaust gas. This can allow for improved energy recovery while also generating high purity streams of carbon dioxide and nitrogen.

Abstract: An adsorption module and associated processes for conducting advanced separations processes such as sorption enhanced water-gas shift (SEWGS). The adsorption module contains at least one angled baffle to create at least two tapered adsorbent beds within the adsorption module. The taper is such that the adsorbent beds' cross-sections within the adsorption module decrease in the direction of feed flow, thereby taking advantage of increased product purity and process efficiency provided by tapered adsorption beds.

Abstract: Systems and methods are provided for combined cycle power generation while reducing or mitigating emissions during power generation. Recycled exhaust gas from a molten carbonate fuel cell power generation reaction can be separated by using a swing adsorption process so as to generate a high purity CO2 stream while reducing or minimizing the energy required for the separation and without having to reduce the temperature of the exhaust gas. A high temperature adsorption reactor adsorbs the CO2 and recovers H2 from an exhaust gas of a first molten carbonate fuel cell at a high temperature and at a low pressure. The reactor passes along the adsorbed CO2 to a cathode and the recovered H2 to an anode of a second molten carbonate fuel cell for further power generation. This can allow for improved energy recovery while also generating high purity streams of CO2 and H2.

Abstract: Systems and methods are provided for performing multistage naphtha reforming with intermediate separation of aromatics using a swing adsorption process. Use of a swing adsorption process can allow aromatics to be selectively removed from the intermediate reforming effluent while reducing or minimizing the energy costs for cooling and subsequent reheating of the intermediate reforming effluent. The resulting aromatics-rich stream generated from swing adsorption can have a substantially higher aromatics content than an aromatics-rich stream generated by conventional separation methods during multi-stage naphtha reforming. In some aspects, selective thermal purging (either hot or cold) can be used to further facilitate adsorption or desorption of components by the adsorbent in the swing adsorption vessel.

Abstract: Methods are provided for the production of nitrogen, hydrogen, and carbon dioxide from an exhaust gas. Exhaust gas from combustion in a fuel rich (or reducing) atmosphere is primarily composed of CO2, CO, N2, H2O, and H2. CO may be converted to CO2 and H2 via the water gas shift reaction. Carbon dioxide may then be effectively separated from nitrogen and hydrogen to produce a carbon dioxide stream and a nitrogen/hydrogen stream. The nitrogen/hydrogen stream may then be effectively separated to produce a high purity nitrogen stream and a high purity hydrogen stream. The process may be done in any order, such as separating the nitrogen first or the carbon dioxide first.

Abstract: In various aspects, methods are provided for hydrogen production while reducing and/or mitigating emissions during various refinery processes that produce syngas, such as power generation. Syngas can be effectively separated to generate high purity carbon dioxide and hydrogen streams, while reducing and/or minimizing the energy required for the separation, and without needing to reduce the temperature of the flue gas. In various aspects, the operating conditions, such as high temperature, mixed metal oxide adsorbents, and cycle variations, for a pressure swing adsorption reactor can be selected to minimize energy penalties while still effectively capturing the CO2 present in syngas.

Abstract: Provided are systems, methods, and apparatus for using nuclear magnetic resonance (NMR) to detect a first material in the presence of a second material within a region of the Earth and within a static magnetic field (such as Earth's magnetic field). These inventions are uniquely suited to detect NMR signals from materials remotely located from a measurement device (e.g., below ice with the device above the ice). They are further useful in detecting first material having relatively short spin-lattice (T1) relaxation time in the presence of second material having longer T1 relaxation time (and therefore slower response to applied magnetic fields). Two pre-polarization currents are used to create pre-polarization magnetic fields stronger than the static magnetic field, each applied over a period of time between the first material's T1 relaxation time and the second material's T1 relaxation time, enabling different ways to null the NMR signal from the second material.

Abstract: Methods and systems for detecting a material within a region of the Earth are provided. The region may be under a surface of earthen formation, ice, snow, or water. The method may be practiced in a variety of applications, for example in an arctic region to detect oil spills, leaks, or seepages. The methods and systems may include using at least one coil to transmit a radio frequency (RF) excitation signal into the region of the Earth; and receive any NMR response signals to determine the presence of the material of interest.

Abstract: The invention features methods panels, cartridges, and systems for detecting pathogens and for diagnosing and treating diseases, including bacteremia and sepsis.

Abstract: The invention features methods, panels, cartridges, kits, and systems for rapid and sensitive detection and identification of pathogens and determination of the pathogen's susceptibility to antimicrobial agents for diagnosis and treatment of disease, including bloodstream infection (e.g., bacteremia and fungemia), and sepsis.