Patents by Inventor Hans Tobler

Hans Tobler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20090030233
    Abstract: The present invention relates to a novel process for the preparation of a compound of formula (I): which comprises reacting a compound of formula (II): with a compound of general formula (III): wherein R1 and R2 are H or C1-4 alkyl or R1 and R2 join together to form a C2-3 alkylene group, which is optionally substituted by from 1 to 4 methyl or ethyl groups, or an anhydride of the compound (III), in the presence of a base and of a palladium catalyst which is (a) a palladium (0)- or palladium (II)-triarylphosphine complex optionally in the presence of additional amounts of a triarylphoshine ligand, or (b) a palladium (II) salt in the presence of a triarylphosphine ligand, or (c) metallic palladium, optionally deposited on a support, in the presence of triarylphosphine; there being used from 0.9 to 2 moles of compound (III) for each mole of compound (II).
    Type: Application
    Filed: November 13, 2006
    Publication date: January 29, 2009
    Applicant: SYNGENTA CROP PROTECTION, INC.
    Inventors: Josef Ehrenfreund, Harald Walter, Hans Tobler, Camilla Corsi
  • Publication number: 20080262242
    Abstract: The present invention relates to a novel process for the preparation of a compound of general formula (I): wherein R1 is H or C1-4 alkyl and R2 is difluoromethyl or trifluoromethyl, which comprises reacting a compound of general formula (II): wherein R1 has the meaning given above and X is chloro or bromo, with a compound of general formula (III): wherein R2 has the meaning given above, in the presence of a base, a palladium catalyst and a ferrocenyl biphoshine ligand of the Josiphos type, the reaction being carried out in an ether solvent at a reflux temperature of at least 100° C.
    Type: Application
    Filed: November 13, 2006
    Publication date: October 23, 2008
    Applicant: SYNGENTA CROP PROTECTION, INC.
    Inventors: Harald Walter, Camilla Corsi, Josef Ehrenfreund, Hans Tobler
  • Publication number: 20080227835
    Abstract: The invention relates to a fungicidally active compound of formula (I): where Het is a 5- or 6-membered heterocyclic ring containing one to three heteroatoms, each independently selected from oxygen, nitrogen and sulphur, the ring being substituted by the groups R6, R7 and R8; R1 is hydrogen, C1-4alkyl, C1-4haloalkyl, C1-4alkoxy, C1-4haloalkoxy, CH2C?CR9, CH2CR10?CHR11, CH?C?CH2 or COR12; R2 and R3 are each, independently, hydrogen, halo, C1-4alkyl, C1-4 alkoxy, C1-4 haloalkyl or C1-4haloalkoxy; R4 and R5 are each independently selected from halo, cyano and nitro; or one of R4 and R5 is hydrogen and the other is selected from halo, cyano and nitro; R6, R7 and R8 are each, independently, hydrogen, halo, cyano, nitro, C1-4alkyl, C1-4haloalkyl, C1-4 alkoxy(C1-4)alkyl, C1-4 haloalkoxy(C1-4)alkyl or C1-4 haloalkoxy, provided that at least one of R6, R7 and R8 is not hydrogen; R9, R10 and R11 are each, independently, hydrogen, halo, C1-4 alkyl, C1-4 haloalkyl or C1-4 alkoxy(C1-4)alkyl; and R12 is hydrogen, C1-6 alk
    Type: Application
    Filed: October 23, 2006
    Publication date: September 18, 2008
    Applicant: SYNGENTA CROP PROTECTION, INC.
    Inventors: Hans Tobler, Harald Walter, Josef Ehrenfreund, Camilla Corsi
  • Publication number: 20080214532
    Abstract: Compounds of the formula (I) in which the substituents are as defined in claim 1 are suitable for use as microbiocides.
    Type: Application
    Filed: March 21, 2006
    Publication date: September 4, 2008
    Inventors: Harald Walter, Camilla Corsi, Josef Ehrenfreund, Clemens Lamberth, Hans Tobler
  • Publication number: 20080188442
    Abstract: Compounds of the formula I in which the substituents are as defined in claim 1 are suitable for use as microbiocides.
    Type: Application
    Filed: July 17, 2006
    Publication date: August 7, 2008
    Applicant: SYNGENTA CROP PROTECTION, INC.
    Inventors: Clemens Lamberth, Camilla Corsi, Josef Ehrenfreund, Hans Tobler, Harald Walter
  • Publication number: 20080161610
    Abstract: The present invention relates to a process for the preparation of compounds of formula (I) wherein the substituents are as defined in claim 1, by a) reaction of a compound of formula (II) to form a compound of formula (III) b) reaction of that compound in the presence of a base to form a compound of formula (IV) c) conversion of that compound in the presence of a reducing agent into a compound of formula (I).
    Type: Application
    Filed: February 20, 2006
    Publication date: July 3, 2008
    Applicant: SYNGENTA CROP PROTECTION, INC.
    Inventors: Harald Walter, Camilla Corsi, Josef Ehrenfreund, Clemens Lamberth, Hermann Schneider, Hans Tobler
  • Publication number: 20080132557
    Abstract: Compounds of the formula (I), in which the substituents are as defined in claim 1 are suitable for use as microbiocides.
    Type: Application
    Filed: June 21, 2005
    Publication date: June 5, 2008
    Applicant: SYNGENTA CROP PROTECTION, INC.
    Inventors: Clemens Lamberth, Camilla Corsi, Josef Ehrenfreund, Hans Tobler, Harald Walter
  • Patent number: 7378399
    Abstract: What is described are a compound of the formula (I) Wherein A-B is —CH?CH— or —CH2—CH2—; n is 0 or 1; R1, is C1-C12alkyl, C3-C8cycloalkyl or C2-C12alkenyl; R2 and R3 for instance are either, (i) independently from each other for instance -Q, —C(?Y)-Q, or —C(?Y)—O-Q; or (ii) together form with the nitrogen atom to which they are bound a three- to seven-membered ring, (iii) together are ?C(R4)R5; R4 and R5 are, independently from each other, for instance -Q, —C(?Y)-Q, or —C(?Y)—O-Q; Y is O or S; Q is for instance H or unsubstituted or mono- to pentasubstituted C1-C12alkyl; or, if appropriate, an E/Z isomer, E/Z isomer mixture and/or tautomer thereof; a process for preparing these compounds, their isomers and tautomers and the use of these compounds, their isomers and tautomers; pesticidal compositions whose active compound is selected from these compounds and their tautomers; intermediates for the preparation of the said compounds of the formula (I), methods for the preparation of the compounds of the formula (
    Type: Grant
    Filed: February 3, 2004
    Date of Patent: May 27, 2008
    Assignee: Merial Limited
    Inventors: Jerome Cassayre, Hans Tobler, Thomas Pitterna, Peter Maienfisch, Fiona Murphy Kessabi, Laura Quaranta, Ottmar Franz Hueter
  • Patent number: 7355065
    Abstract: The present invention relates to a process for the preparation of a compound of the formula (I), wherein R is C1?12 alkyl, by the contact of a compound of the general formula (II), wherein R1 and R2 are each, independently, C1?12 alkyl; or R1 and R2 join together with the nitrogen atom to which they are attached to form an alicyclic amine ring containing 4 to 7 carbon atoms or a morpholine ring, with an acetic acid ester of the general formula (III) CH3COOR, wherein R is as defined under formula (I), in the presence of a base.
    Type: Grant
    Filed: July 13, 2005
    Date of Patent: April 8, 2008
    Assignee: Syngenta Crop Protection, Inc.
    Inventors: Harald Walter, Camilla Corsi, Josef Ehrenfreund, Clemens Lamberth, Hans Tobler
  • Publication number: 20080076664
    Abstract: A method of controlling phytopathogenic diseases on useful plants or on propagation material thereof, which comprises applying to the useful plants, the locus thereof or propagation material thereof a combination of components A) and B) in a synergistically effective amount, wherein component A) is a compound of formula (I), wherein R1 is difluoromethyl or trifluoromethyl and R2 is C1-C6alkyl, C1-C4alkoxy-C1-C6 alkyl or C1-C6 haloalkyl; or a tautomer of such a compound; and component B) is a compound selected from compounds known for their fungicidal and/or insecticidal activity, is particularly effective in controlling or preventing fungal diseases of useful plants.
    Type: Application
    Filed: October 6, 2005
    Publication date: March 27, 2008
    Inventors: Harald Walter, Camilla Corsi, Josef Ehrenfreund, Clemens Lamberth, Hans Tobler
  • Publication number: 20080070785
    Abstract: The invention relates to fungicidal compositions comprising as active ingredient a combination of components A) and B) as defined in the patent claims, to a method of controlling phytopathogenic diseases on crop plants using such a compositions and to a method of protecting natural substances of vegetable and/or animal origin and/or their processed forms using such a composition.
    Type: Application
    Filed: August 11, 2005
    Publication date: March 20, 2008
    Applicant: SYNGENTA CROP PROTECTION, INC.
    Inventors: Harald Walter, Urs Neuenschwander, Ronald Zeun, Josef Ehrenfreund, Hans Tobler, Camilla Corsi, Clemens Lamberth
  • Publication number: 20080051446
    Abstract: The invention relates to a fungicidally active compound of formula (I): where Het is a 5- or 6-membered heterocyclic ring containing one to three heteroatoms, each independently selected from oxygen, nitrogen and sulphur, provided that the ring is not 1,2,3-triazole, the ring being substituted by groups R8, R9 and R10; X is a single or double bond; Y is O, S, N(R11) or (CR12R13)(CR14R15)m(CR16R17)n; m is 0 or 1; n is 0 or 1; and R1 to R17 each, independently, have a range of values; to the preparation of these compounds, to novel intermediates used in the preparation of these compounds, to agrochemical compositions which comprise at least one of the novel compounds as active ingredient, to the preparation of the compositions mentioned and to the use of the active ingredients or compositions in agriculture or horticulture for controlling or preventing infestation of plants by phytopathogenic microorganisms, preferably fungi.
    Type: Application
    Filed: October 14, 2003
    Publication date: February 28, 2008
    Inventors: Josef Ehrenfreund, Hans Tobler, Harald Walter
  • Publication number: 20080004465
    Abstract: The present invention relates to a process for the preparation of a compound of the formula (I), wherein R is C1-12 alkyl, by the contact of a compound of the general formula (II), wherein R1 and R2 are each, independently, C1-12 alkyl; or R1 and R2 join together with the nitrogen atom to which they are attached to form an alicyclic amine ring containing 4 to 7 carbon atoms or a morpholine ring, with an acetic acid ester of the general formula (III) CH3COOR, wherein R is as defined under formula (I), in the presence of a base.
    Type: Application
    Filed: July 13, 2005
    Publication date: January 3, 2008
    Inventors: Harald Walter, Camilla Corsi, Josef Ehrenfreund, Clemens Lamberth, Hans Tobler
  • Patent number: 7312179
    Abstract: A fungicidally active compound of formula (I): where X is (X1), (X2) or (X3); Het is a 5- or 6-membered heterocyclic ring containing one to three heteroatoms, each independently selected from oxygen, nitrogen and sulphur, provided that the ring is not 1,2,3-triazole, the ring being substituted by groups R4, R5 and R6; R1 and R2 are each, independently, hydrogen, halo or methyl; R3 is optionally substituted C2-12 alkyl, optionally substituted C2-12 alkenyl, optionally substituted C2-12 alkynyl, optionally substituted C3?12 cycloalkyl, optionally substituted phenyl or optionally substituted heterocyclyl; R4, R5 and R6 are each, independently, selected from hydrogen, halo, cyano, nitro, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy(C1-4)alkylene and C 1-4 haloalkoxy(C1-4)alkylene, provided that at least one of R4, R5 and R6 is not hydrogen; and R7 and R8 are each, independently, hydrogen, halogen, C1-4 alkyl or Clue haloalkyl; the invention also relates to the preparation of these compounds, to novel intermediates use
    Type: Grant
    Filed: October 24, 2003
    Date of Patent: December 25, 2007
    Assignee: Syngenta Crop Protection, Inc.
    Inventors: Josef Ehrenfreund, Hans Tobler, Harald Walter
  • Publication number: 20070265267
    Abstract: A method of controlling phytopathogenic diseases on useful plants or on propagation material thereof, which comprises applying to the useful plants, the locus thereof or propagation material thereof a combination of components A) and B) in a synergistically effective amount, wherein component A) is a compound of formula I wherein R1 is difluoromethyl or trifluoromethyl; Y is —CHR2— or and R2 is hydrogen or C1-C6alkyl; or a tautomer of such a compound; and component B) is a compound selected from compounds known for their fungicidal and/or insecticidal activity, is particularly effective in controlling or preventing fungal diseases of useful plants.
    Type: Application
    Filed: April 5, 2007
    Publication date: November 15, 2007
    Applicant: Syngenta Crop Protection, Inc.
    Inventors: Harald WALTER, Camilla Corsi, Josef Ehrenfreund, Clemens Lamberth, Hans Tobler
  • Publication number: 20070244121
    Abstract: A method of controlling phytopathogenic diseases on useful plants or on propagation material thereof, which comprises applying to the useful plants, the locus thereof or propagation material thereof a combination of components A) and B) in a synergistically effective amount, wherein component A) is a compound of formula (I), wherein R1 is difluoromethyl or trifluoromethyl; Y is —CHR2— or formula (DD) and R2 is hydrogen or C1-C6alkyl; or a tautomer of such a compound; and component B) is a compound selected from compounds known for their fungicidal and/or insecticidal activity, is particularly effective in controlling or preventing fungal diseases of useful plants.
    Type: Application
    Filed: October 6, 2005
    Publication date: October 18, 2007
    Applicant: Syngenta Crop Protection, Inc.
    Inventors: Harald Walter, Camilla Corsi, Josef Ehrenfreund, Clemens Lamberth, Hans Tobler
  • Patent number: 7241721
    Abstract: A fungicidally active compound of formula (I): where Het is a substituted 5- or 6-membered heterocyclic ring; R1 is hydrogen, formyl, CO—C1-4 alkyl, COO—C1-4 alkyl, C1-4 alkoxy(C1-4)alkylene, CO—C1-4 alkylenoxy(C1-4)alkyl, propargyl or allenyl; R2, R3, R4 and R5 are each, independently, hydrogen, halogen, methyl or CF3; each R6 is, independently, halogen, methyl or CF3; R7 is (Z)mC?C(Y1), (Z)mC(Y1)?C(Y2)(Y3) or tri(C1-4)alkylsilyl; X is O or S; Y1, Y2 and Y3 are each, independently, hydrogen, halogen, C1-6 alkyl [optionally substituted by one or more substituents each independently selected from halogen, hydroxy, C1-4 alkoxy, C1-4 haloalkoxy, C1-4 alkylthio, C1-4 haloalkylthio, C1-4 alkylamino, di(C1-4)alkylamino, C1-4 alkoxycarbonyl, C1-4 alkylcarbonyloxy and tri(C1-4)alkylsilyl], C2-4 alkenyl [optionally substituted by one or more substituents each independently selected from halogen], C2-4 alkynyl [optionally substituted by one or more substituents each independently selected from halogen], C3-7 cycloalkyl
    Type: Grant
    Filed: December 15, 2003
    Date of Patent: July 10, 2007
    Assignee: Syngenta Crop Protection, Inc.
    Inventors: Josef Ehrenfreund, Clemens Lamberth, Hans Tobler, Harald Walter
  • Publication number: 20060287328
    Abstract: Fungicidal compounds of formula (1): where X is O or S; RING is phenyl or thienyl; Het is a 5- or 6-membered heterocyclic ring containing one to three heteroatoms, each independently selected from oxygen, nitrogen and sulphur, the ring being substituted by one to four groups R4; R1 is hydrogen, optionally substituted (C1-4)alkyl, formyl, optionally substituted (C1-4)alkylC(?O), optionally substituted (C1-4)alkylC(?O)O, optionally substituted (C1-4)alkoxy(C1-4)alkyl, optionally substituted allyl, optionally substituted propargyl or optionally substituted allenyl; each R2 is, independently, halogen, optionally substituted (C1-4)alkyl, optionally substituted (C1-4)alkoxy or optionally substituted (C1-4)alkoxy(C1-4)alkyl; R3 is (CRaRb)m-Cy-(CRcRd)n—Y; each R4 is, independently, selected from halogen, C1-3 alkyl, C1-3 haloalkyl, C1-3alkoxy(C1-3)alkyl and cyano; Ra, Rb, Rc and Rd are each, independently, hydrogen or optionally substituted (C1-4)alkyl; Cy is an optionally substituted carbocyclic or heterocyclic 3-7
    Type: Application
    Filed: September 8, 2004
    Publication date: December 21, 2006
    Inventors: Josef Ehrenfreund, Clemens Lamberth, Hans Tobler, Harald Walter
  • Publication number: 20060276434
    Abstract: The invention also relates to novel compounds of formula (I) where Het is a 5- or 6-membered heterocyclic ring containing one to three heteroatoms, each independently selected from oxygen, nitrogen and sulphur, the ring being substituted by one to three groups R4; R1 is hydrogen, optionally substituted (C1-4)alkyl, formyl, optionally substituted (C1-4)alkylC(?O), optionally substituted (C1-4)alkylC(?O)O, optionally substituted (C1-4)alkoxy(C1-4)alkyl, optionally substituted allyl, optionally substituted propargyl or optionally substituted allenyl; each R2 is, independently, halogen, optionally substitute (C1-4)alkyl, optionally substituted (C1-4)alkoxy or optionally substituted (C1-4)alkoxy(C1-4)alkyl; R3 is either position 2 or at position 4 of the thiophene ring and is an organic group containing three to thirteen carbon atoms and al least one silicon atom and, optionally, one to three heteroatoms, each independently selected from oxygen, nitrogen and sulphur, and is optionally substituted by one to four in
    Type: Application
    Filed: April 21, 2004
    Publication date: December 7, 2006
    Inventors: Josef Ehrenfreund, Harald Walter, Hans Tobler, Clemens Lamberth
  • Publication number: 20060205595
    Abstract: A compound of the general formula (I) pesticidal compositions whose active compound is selected from these compounds and their tautomers; intermediates for the preparation of the said compounds of the formula (I)m methods for the preparation of the compounds of the formula (I), and a method for controlling pests using these compositions.
    Type: Application
    Filed: January 30, 2004
    Publication date: September 14, 2006
    Inventors: Thomas Pitterna, Peter Maienfisch, Fiona Murphy Kessabi, Hans Tobler, Jerome Cassayre, Laura Quaranta