Patents by Inventor HANS TOMAS BJORNSSON

HANS TOMAS BJORNSSON has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for treating mendelian disorders of the epigenetic machinery
    Patent number: 11357748
    Abstract: A method is provided for treating a Mendelian disorder of the epigenetic machinery in a subject in need thereof. In particular, the method comprises administering a therapeutically effective amount of an agent that restores balance between open and closed chromatin states at one or more target genes, wherein the agent that restores balance between open and closed chromatin states at one or more target genes is an agent that ameliorates the effect of a defective gene encoding a component of the epigenetic machinery.
    Type: Grant
    Filed: May 29, 2015
    Date of Patent: June 14, 2022
    Assignee: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Hans Tomas Bjornsson, Harry Dietz
  • Compositions and methods for treating kabuki syndrome and related disorders
    Patent number: 10568854
    Abstract: A method is provided for treating a Mendelian disorder of the epigenetic machinery (e.g., Kabuki syndrome) in a subject in need thereof. In particular, the method comprises administering to the subject a ketogenic composition in an amount sufficient to produce a physiologically acceptable ketosis in the subject. A method for selecting a subject for treatment of a Mendelian disorder of the epigenetic machinery (e.g., Kabuki syndrome) is also provided. Ketogenic compositions and kits useful for practicing the methods are also provided.
    Type: Grant
    Filed: May 29, 2015
    Date of Patent: February 25, 2020
    Assignee: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Hans Tomas Bjornsson, Harry Dietz, Joel Benjamin
  • Genetically encoded histone reporter allele constructs
    Patent number: 10246498
    Abstract: Non-FRET-based fusion protein reporter molecules are provided that can be used to monitor histone modifications in living cells. Transgenic animals, particularly non-human mammals, whose genomes comprise an expression cassette encoding a non-FRET-based fusion protein reporter, are also provided. Methods of using the fusion reporter molecules for diagnosing histone-modification-associated disorders and to identify candidate pharmaceutical agents that effect histone modification in cells and tissues are also provided.
    Type: Grant
    Filed: May 29, 2015
    Date of Patent: April 2, 2019
    Assignee: The Johns Hopkins University
    Inventors: Hans Tomas Bjornsson, Harry Dietz
  • GENETICALLY ENCODED HISTONE REPORTER ALLELE CONSTRUCTS
    Publication number: 20170114108
    Abstract: Non-FRET-based fusion protein reporter molecules are provided that can be used to monitor histone modifications in living cells. Transgenic animals, particularly non-human mammals, whose genomes comprise an expression cassette encoding a non-FRET-based fusion protein reporter, are also provided. Methods of using the fusion reporter molecules for diagnosing histone-modification-associated disorders and to identify candidate pharmaceutical agents that effect histone modification in cells and tissues are also provided.
    Type: Application
    Filed: May 29, 2015
    Publication date: April 27, 2017
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: HANS TOMAS BJORNSSON, HARRY DIETZ
  • COMPOSITIONS AND METHODS FOR TREATING KABUKI SYNDROME AND RELATED DISORDERS
    Publication number: 20170100354
    Abstract: A method is provided for treating a Mendelian disorder of the epigenetic machinery (e.g., Kabuki syndrome) in a subject in need thereof. In particular, the method comprises administering to the subject a ketogenic composition in an amount sufficient to produce a physiologically acceptable ketosis in the subject. A method for selecting a subject for treatment of a Mendelian disorder of the epigenetic machinery (e.g., Kabuki syndrome) is also provided. Ketogenic compositions and kits useful for practicing the methods are also provided.
    Type: Application
    Filed: May 29, 2015
    Publication date: April 13, 2017
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: HANS TOMAS BJORNSSON, HARRY DIETZ, JOEL BENJAMIN
  • METHODS FOR TREATING MENDELIAN DISORDERS OF THE EPIGENETIC MACHINERY
    Publication number: 20170095436
    Abstract: A method is provided for treating a Mendelian disorder of the epigenetic machinery in a subject in need thereof. In particular, the method comprises administering a therapeutically effective amount of an agent that restores balance between open and closed chromatin states at one or more target genes, wherein the agent that restores balance between open and closed chromatin states at one or more target genes is an agent that ameliorates the effect of a defective gene encoding a component of the epigenetic machinery.
    Type: Application
    Filed: May 29, 2015
    Publication date: April 6, 2017
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: HANS TOMAS BJORNSSON, HARRY DIETZ