Abstract: The present disclosure provides methods and systems for the capture and enrichment of target nucleic acids and analysis of the enriched target nucleic acids for detecting balanced chromosomal aberrations including translocations and inversions. The present disclosure provides for the enrichment of targeted sequences in a format whereby one fusion partner gene on a capturing platform is represented to allow subsequent sequencing of chimeric nucleic acids (i.e., nucleic acid strands that carry information on different DNA regions of a genome). Such a design enables identification of novel fusion partner genes occurring as a result of a chromosomal translocation or inversion.

Abstract: The present disclosure provides methods and systems for the capture and enrichment of target nucleic acids and analysis of the enriched target nucleic acids for detecting balanced chromosomal aberrations including translocations and inversions. The present disclosure provides for the enrichment of targeted sequences in a format whereby one fusion partner gene on a capturing platform is represented to allow subsequent sequencing of chimeric nucleic acids (i.e., nucleic acid strands that carry information on different DNA regions of a genome). Such a design enables identification of novel fusion partner genes occurring as a result of a chromosomal translocation or inversion.

Abstract: A biological purification process, a secondary treatment of partially cleaned waste water for example, is carried out in a porous bed of loose granules which float in the liquid. The granules are continuously washed to remove coagulated impurities by means of a small quantity thereof being entrained from the top of the bed in a small volumn flow of the effluent of the process, mixed with the inflowing impure liquid and then returned to the bottom of the bed. Excess reaction gas may also be delivered to the bed via the inflowing liquid and unreacted gas collected for reuse.

Abstract: In a process and apparatus for the biological purification of water by means of a closed percolating filter operated with pure oxygen and/or air, and an upward-flow filter disposed downstream of the percolating filter, with flotation filter material therein, saturation of the gas cushion predominantly containing oxygen in the percolating filter is controlled by selection of the operating pressure in such a fashion that the oxygen supply corresponds to the biochemical oxygen demand of the water on the one hand, while on the other hand a residual oxygen content dissolved in the water permits continuation with a biological fine purification operation in the upward-flow filter. The apparatus comprises a first chamber with the percolating filter, the water flowing downwardly therethrough, and a second chamber with filter material through which the water flows upwardly.