Patents by Inventor HANS-WERNER MEWES

HANS-WERNER MEWES has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MOLECULES TARGETING RIBOSOMAL PROTEIN RPL35/UL29 FOR USE IN THE TREATMENT OF DISEASES, IN PARTICULAR EPIDERMOLYSIS BULLOSA (EB)
    Publication number: 20230288402
    Abstract: The present invention relates to a method for identifying a pharmaceutically active compound that modulates the rpL35 (rpL35/rpL29)-dependent translation of at least one mRNA in a mammalian cell. The mRNA may comprise a premature termination codon (PTC), undergoes premature translation termination, causes programmed ?1 ribosomal frame shifting (?1PRF), or is a polycistronic mRNA. Furthermore a respective screening system, methods of treating or preventing a disease or condition, and compounds that modulate the rpL35 (rpL35/rpL29)-dependent translation, in particular atazanavir or derivatives thereof and artemisinin or artesunate or derivatives thereof are provided.
    Type: Application
    Filed: July 30, 2021
    Publication date: September 14, 2023
    Inventors: HANNELORE BREITENBACH-KOLLER, JÖRG VON HAGEN, HELMUT HINTNER, FRIEDRICH LOTTSPEICH, HANS-WERNER MEWES, NORBERT MÜLLER, ANDREAS FRIEDRICH, KATHARINA ELSENSOHN, CLAUDIA MOSSHAMMER, MICHAEL WIESSNER, THOMAS KARL, JAN SCHERNTHANER, ADRIANA RATHNER