Patents by Inventor Hans Wielinger
Hans Wielinger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20040077092Abstract: Control and calibration material for blood coagulation tests The invention concerns control and calibration materials for coagulation tests which contain plasma and a substance or a mixture of substances which prolongs the clotting time of the plasma.Type: ApplicationFiled: May 14, 2003Publication date: April 22, 2004Inventors: Hans Wielinger, Rainer Fuellemann, Erika Abel
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Patent number: 5895704Abstract: The subject of the invention is an article for collecting and transporting a sample to be analyzed; containing an absorbent matrix to absorb a liquid sample, characterized in that the absorbent matrix represents the sample collecting area of a sample collecting element, which is an integral part of an envelope. In addition, the subject of the invention is a process for determining an analyte, in which liquid sample material is placed on an absorbent matrix, dried, sent to a laboratory and tested there, characterized in that the liquid sample material is placed on an absorbent matrix that represents the sample collecting area of a sample collecting element, which is an integral part of an envelope.Type: GrantFiled: November 27, 1996Date of Patent: April 20, 1999Assignee: Boeringer Mannheim GmbHInventors: Rolf Lerch, Gregor Bainczyk, Hans Wielinger, Jack Bush
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Patent number: 5783759Abstract: Disclosed is an element for collecting, transporting and storing sample material to be analyzed containing absorptive matrix material. The element contains a first and a second layer of absorptive matrix material which are arranged side by side, next to, and touching one another on an inert support material in a contact enabling liquid transfer in such a manner that liquid can pass from the first into the second layer when the first layer is filled with liquid. The first layer can be completely separated from the second layer after applying and drying the sample material. Also disclosed is a system containing such an element and a closable envelope in which the element can be transported. In addition, the invention concerns a method for analyzing a liquid sample material in which the liquid sample material is applied to an element according to the invention, the first layer is separated from the second layer of absorptive matrix material for analysis and is subsequently eluted.Type: GrantFiled: June 24, 1996Date of Patent: July 21, 1998Assignee: Boehringer Mannheim GmbHInventors: Hans Wielinger, Rolf Lerch, Wolfgang Werner
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Patent number: 5521060Abstract: A sparingly soluble salt of a heteropoly acid is used for the determination of an analyte which is an aromatic amine rich in electrons or together with another substance leads to such an amine. The analyte is determined by means of the heteropoly blue color formed.Type: GrantFiled: October 12, 1994Date of Patent: May 28, 1996Assignee: Boehringer Mannheim GmbHInventors: Joachim Hoenes, Hans Wielinger, Volker Unkrig
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Patent number: 5382523Abstract: A sparingly soluble salt of a heteropoly acid is used for the determination of an analyte which is an aromatic amine rich in electrons or together with another substance leads to such an amine. The analyte is determined by means of the heteropoly blue color formed.Type: GrantFiled: April 13, 1993Date of Patent: January 17, 1995Assignee: Boehringer Mannheim GmbHInventors: Joachim Hoenes, Hans Wielinger, Volker Unkrig
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Patent number: 5240860Abstract: A sparingly soluble salt of a heteropoly acid is used for the determination of an analyte which is an aromatic amine rich in electrons or together with another substance leads to such an amine. The analyte is determined by means of the heteropoly blue color formed.Type: GrantFiled: December 3, 1990Date of Patent: August 31, 1993Assignee: Boehringer Mannehim GmbHInventors: Joachim Hoenes, Hans Wielinger, Volker Unkrig
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Patent number: 5190862Abstract: The present invention provides compounds of the general formula: ##STR1## wherein R.sup.1 is an amino acid residue or a residue of an oligopeptide in which the amino groups are optionally substituted by protective groups, R.sup.2 and R.sup.3, which are the same or different, are hydrogen atoms, a lower alkyl, lower alkoxy, carboxyl or lower alkoxycarbonyl radicals or carboxamido groups optionally substituted by lower alkyl or, if R.sup.2 and R.sup.3 are adjacent, can represent a --CH.dbd.CH--CH.dbd.CH-- radical, Z is conjugated-through positively charged, bicyclic heterocyclic system and X is an anion of an organic or inorganic acid. The present invention also provides processes for the preparation of these compounds and diagnostic agents containing them for the determination of peptide bond-cleaving enzymes.Type: GrantFiled: October 11, 1991Date of Patent: March 2, 1993Assignee: Boehringer Mannheim GmbHInventors: Hans Wielinger, Gerd Zimmermann
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Patent number: 5108890Abstract: The present invention provides compounds of the general formula: ##STR1## wherein R.sup.1 is an amino acid residue or a residue of an oligopeptide in which the amino groups are optionally substituted by protective groups, R.sup.2 and R.sup.3, which are the same or different, are hydrogen atoms, a lower alkyl, lower alkoxy, carboxyl or lower alkoxycarbonyl radicals or carboxamido groups optionally substituted by lower alkyl or, if R.sup.2 and R.sup.3 are adjacent, can represent a --CH.dbd.CH--CH.dbd.CH-- radical, Z is a conjugated-through positively charged, bicyclic heterocyclic system and X is an anion of an organic or inorganic acid. The present invention also provides processes for the preparation of these compounds and diagnostic agents containing them for the determination of peptide bond-cleaving enzymes.Type: GrantFiled: March 31, 1988Date of Patent: April 28, 1992Assignee: Boehringer Mannheim GmbHInventors: Hans Wielinger, Gerd Zimmermann
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Patent number: 5059525Abstract: The present invention provides a dry reagent for blood coagulation tests in which an at least partial course of the coagulation cascade takes place, comprising a carrier material which contains a chromophoric substrate of a protease of the blood coagulation system, at least one factor and/or co-factor of the blood coagulation system and a buffer.Type: GrantFiled: May 29, 1990Date of Patent: October 22, 1991Assignee: Boehringer Mannheim GmbHInventors: Knut Bartl, Udo Becker, Helmut Lill, Hans Wielinger
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Patent number: 4966855Abstract: The invention provides new redox indicators and uses for these redox compounds (I): ##STR1## Wherein X is oxygen or sulphur, R.sub.1 is julolidine or tetrahydroquinoline, which can carry an alkyl radical on the nitrogen atom which, in turn, can be substituted by a sulphuric, phosphonic or carboxylic acid residues, or is (II); wherein R.sub.4 is hydroxyl or a mono- or dialkylated amino group, R.sub.5 and R.sub.6, which can be the same or different, are hydrogen, alkyl or alkoxy, R.sub.2 is hydrogen or alkyl, julolidine or tetrahydroquinoline, which can carry an alkyl on the nitrogen atom which alkyl can be substituted by sulphuric, phosphonic or carboxylic acids, or is III; wherein R.sub.5 and R.sub.6 are the same as in R.sub.1 and R'.sub.4 is hydroxyl, an amino or a mono-or dialkylated amino group, whereby the alkyl radicals can be substituted one or more times by hydroxyl, alkoxy, halogen, morpholine or a sulphuric, carboxylic or phosphonic acid residue, which acids can also be esterified, and R.sub.Type: GrantFiled: July 2, 1985Date of Patent: October 30, 1990Assignee: Boehringer Mannheim GmbHInventors: Ulfert Deneke, Werner Guthlein, Wolfgang Weckerle, Hans Wielinger
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Patent number: 4910150Abstract: The present invention provides a test carrier for the determination of coagulation parameters, wherein it includes a test layer which contains glass fibres which are coated with polyvinyl alcohol or polyvinyl alcohol/vinyl acetate.The present invention also provides a process for the production of a glass fibre layer, wherein glass fibres are slurried in an excess of water with the addition of polyvinyl alcohol and a layer is formed according to a process conventional for the production of paper and dried at an elevated temperature.Furthermore, the present invention provides a process for the determination of coagulation parameters of blood, wherein it includes a process step in which blood is passed through a glass fibre layer which contains glass fibres which have been coated with polyvinyl alcohol or polyvinyl alcohol/vinyl acetate.Type: GrantFiled: September 19, 1988Date of Patent: March 20, 1990Assignee: Boehringer Mannheim GmbHInventors: Jurgen Doeding, Hans Wielinger, Rolf Lerch
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Patent number: 4861712Abstract: The present invention provides an analysis element for the determination of coagulation parameters with the help of a detectable or a detection reaction-initiating substrate of a protease of the blood coagulation system and at least one factor and/or co-factor of the blood coagulation system and a buffer substance, wherein the factor and/or co-factor, together with a water-soluble, non-ionic polymer which does not falsely influence the course of the coagulation cascade, is impregnated on an open, planar composite structure which consists of a material which does not have a disturbing influence on the course of the coagulation.Type: GrantFiled: May 4, 1987Date of Patent: August 29, 1989Assignee: Boehringer Manneheim GmbHInventors: Knut Bartl, Helmut Lill, Hans Wielinger
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Patent number: 4788152Abstract: The present invention provides a test carrier for the determination of coagulation parameters, wherein it includes a test layer which contains silanized glass fibres which are coated with polyvinyl alcohol or polyvinyl alcohol/vinyl acetate.Type: GrantFiled: March 19, 1987Date of Patent: November 29, 1988Assignee: Boehringer Mannheim GmbHInventors: Jurgen Doeding, Hans Wielinger, Rolf Lerch
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Patent number: 4786603Abstract: Hydrophilic glass fibers which have bonded to their surfaces a layer of silane molecules of the formula ##STR1## are useful for the separation of plasma from blood for haemostasiological testing. In the formula: the molecule is bonded at its end oxygen to a surface of a glass fibre; R.sub.1 is C.sub.2 -C.sub.6 alkylene; X is OH, C.sub.1 -C.sub.6 alkoxy, having n carbon atoms and up to (n-1) OH groups in which n is 1-6, or an amino acid or peptide residue; and each of R'.sub.3 and R".sub.3 is C.sub.1 -C.sub.6 alkyl, an oxygen bridge to the silicon atom of another silane molecule or an oxygen bridge to the glass surface. The fibres have an average diameter of from 0.2 to 5 microns and a density of 0.1 to 0.5 g/cm.sup.3.Type: GrantFiled: March 4, 1987Date of Patent: November 22, 1988Assignee: Boehringer Mannheim GmbHInventors: Hans Wielinger, Helmut Freitag
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Patent number: 4665023Abstract: The present invention provides imidazole derivatives of the general formula: ##STR1## wherein R, R.sub.1 and R.sub.2 are defined hereinbelow. The present invention is also concerned with processes for the preparation of these imidazole derivatives and with the use thereof as redox indicators.Type: GrantFiled: March 29, 1985Date of Patent: May 12, 1987Assignee: Boehringer Mannheim GmbHInventors: Ulfert Deneke, Werner Guthlein, Manfred Kuhr, Hartmut Merdes, Hans-Rudiger Murawski, Hans Wielinger
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Patent number: 4638023Abstract: The present invention provides a process for the production of reagent films in which an aqueous synthetic resin dispersion which contains the usual adjuvants and reagents is coated on to a solid substrate or on to a thin fabric in a thin layer and dried, wherein to the crude film mass used for the coating there are added 0.5 to 5% by weight of a scleroprotein hydrolysate with a molecular weight of from 5000 to 50,000 and 0.5 to 10% by weight of a higher alcohol containing 5 to 10 carbon atoms.Type: GrantFiled: February 13, 1985Date of Patent: January 20, 1987Assignee: Boehringer Mannheim GmbHInventors: Heinz-Freidrich Trasch, Anselm Rothe, Bernward Sojka, Wolfgang Werner, Hans Wielinger
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Patent number: 4300905Abstract: Compositions and methods for rapidly determining ascorbic acid in aqueous solutions, consisting of an absorbent carrier containing 2,18-phosphomolybdic acid, an aliphatic hydroxycarboxylic acid buffer to adjust the test to pH 2.5 to 5.0, and an alkali chlorate; process for the preparation of such tests.Type: GrantFiled: May 15, 1980Date of Patent: November 17, 1981Assignee: Boehringer Mannheim GmbHInventors: Manfred Bleisteiner, Walter Rittersdorf, Hans Wielinger
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Patent number: 4297271Abstract: The invention provides a diagnostic agent for the detection of occult blood in feces comprising hydrogen peroxide and, as a chromogen, guaiaconic acid A, optionally with a stabilizer. The invention provides, as a novel substance, guaiaconic acid A having a specific extinction E.sub.1 cm.sup.1% at 600 nm of at least 200, determined by the reaction with peroxidase and hydrogen peroxide, having infra-red bands at1600 cm.sup.-1 (m);1505 cm.sup.-1 (v.s.);1206 cm.sup.-1 (s;b);1115 cm.sup.-1 (m);1025 cm.sup.-1 (m); and1200 cm.sup.-1 (s;b)and having an R.sub.F value of 0.45 (toluene/dioxan/glacial acetic acid; 90:25:10 v/v/v).Type: GrantFiled: January 25, 1980Date of Patent: October 27, 1981Assignee: Boehringer Mannheim GmbHInventors: Werner Guthlein, Hans Wielinger, Walter Rittersdorf, Wolfgang Werner
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Patent number: 4250256Abstract: Microbiological test device having a nutrient card or cards and a covering layer thereover which is permeable to nutrients but impermeable to bacteria. The covering layer is made from an aqueous dispersion of a water insoluble resin and a pore former.Type: GrantFiled: June 1, 1979Date of Patent: February 10, 1981Assignee: Boehringer Mannheim GmbHInventors: Hans Wielinger, Walter Rittersdorf, Manfred Bleisteiner, Gerd Zimmermann, Wolfgang Werner, Wolfgang Vomel
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Patent number: 4220713Abstract: The invention provides a diagnostic agent for the detection of (a) hydroperoxides or of substances which react with the liberation of hydroperoxides or of (b) peroxidase or of peroxidatively-active substances, comprising a stabilized oxidation indicator and, in case (a), peroxidase or a peroxidatively active substance or, in case (b), hydroperoxide or a substance which reacts with the liberation of hydroperoxides; wherein the stabilizer is a 1-arylsemicarbazide of the formulaAr--NH--NH--CO--NH.sub.2in which Ar is aryl or aryl substituted with alkyl, alkoxy or halogen.Type: GrantFiled: March 31, 1978Date of Patent: September 2, 1980Assignee: Boehringer Mannheim GmbHInventors: Walter Rittersdorf, Hugo Tiedmann, Wolfgang Werner, Hans Wielinger