Abstract: The invention relates to agents for the treatment, therapy and inhibition of Flaviviridae virus infections, which agents comprise proteasome inhibitors as the active component. The agents which are used for inhibiting the release, maturation and replication of Flaviviridae comprise, as the active component in pharmaceutical preparations, substance classes which share the common property of inhibiting the 26S proteasome in cells. These substance classes include, in particular, proteasome inhibitors which affect the activities of the ubiquitin/proteasome pathway, in particular the enzymic activities of the 26S and the 20S proteasome complex. The application of the invention lies in the antiviral therapy of Flaviviridae infections, especially in preventing the establishment and maintenance of a chronic hepatitis C virus infection and a hepatopathogenesis which is associated therewith.

Abstract: The invention relates to ?-L-N4-hydroxycytosine nucleo-sides, pharmaceutical agents comprising same, and to the use of said ?-L-N4-hydroxycytosine nucleosides and pharmaceutical agents in the prophylaxis or therapy of an infection caused by hepatitis B virus (HBV) or human immunodeficiency virus (HIV). The invention also relates to a method for the preparation of said ?-L-nucleoside analogs.

Abstract: The invention relates to methods of treating a hepatitus virus infection by administering a therapeutically effective amount of a proteasome inhibitor and a pharmaceutically acceptable carrier to a subject in need thereof. Preferably, the protesome in hibitor inhibits or regulates a ubiquitin proteasome pathway.

Abstract: The present invention is directed to the human and murine K203 protein and gene and to K203 binding compounds. Furthermore, the present invention relates to a pharmaceutical and diagnostic composition for use in the diagnosis and treatment of cancer as well as to a method for the diagnosis of cancer and a method of treating same.

Abstract: Nucleoside analogs, nucleic acids and pharmaceutical agents comprising same, and to the use of said nucleoside analogs, nucleic acids and pharmaceutical agents in the diagnosis, prophylaxis or therapy of a viral, bacterial, fungicidal and/or parasitic infection, or of cancer, particularly of hepatitis infections. The invention also relates to a method for the preparation of said nucleoside analogs and to a kit and the use thereof in the prophylaxis and therapy of viral diseases, particularly of hepatitis infections. As stated in 37 C.F.R. §1.72(b): A brief abstract of the technical disclosure in the specification must commence on a separate sheet, preferably following the claims, under the heading “Abstract of the Disclosure.” The purpose of the abstract is to enable the Patent and Trademark Office and the public generally to determine quickly from a cursory inspection the nature and gist of the technical disclosure. The abstract shall not be used for interpreting the scope of the claims.

Abstract: The invention relates to agents for the treatment, therapy and inhibition of Flaviviridae virus infections, which agents comprise proteasome inhibitors as the active component. The agents which are used for inhibiting the release, maturation and replication of Flaviviridae comprise, as the active component in pharmaceutical preparations, substance classes which share the common property of inhibiting the 26S proteasome in cells. These substance classes include, in particular, proteasome inhibitors which affect the activities of the ubiquitin/proteasome pathway, in particular the enzymic activities of the 26S and the 20S proteasome complex. The application of the invention lies in the antiviral therapy of Flaviviridae infections, especially in preventing the establishment and maintenance of a chronic hepatitis C virus infection and a hepatopathogenesis which is associated therewith.

Abstract: The invention relates to agents for the treatment of viral infections, in particular, infections with hepatitis and retro-viruses. Said agents inhibit the release, maturation and replication of both retro-viruses and also hepatitis viruses. In the example of human immune deficiency virus (HIV) and hepatitis-B viruses it has been shown that proteasome inhibitors block the release of virus particles and the infectiousness of the released viral particles and thus the reproduction of the viruses. The proteasome inhibitors affect the activities in the ubiquitin/proteasome pathway, in particular the enzymatic activities of the 26S and the 20S proteasome complexes. The application for the above invention lies in anti-retroviral therapy, particularly the treatment of HIV infections and AIDS and in the anti-viral therapy of hepatitis infections, in particular the treatment of acute and chronic HBV and HCV infections and the associated liver carcinomas.