Patents by Inventor Hans Wissmann
Hans Wissmann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6103486Abstract: A method for determining the concentration of the free fraction of an active compound, present in a biological fluid, in the presence of natural binders, the free and bound fractions of the active compound being in mutual equilibrium, bya) contacting a sample of the fluid with an unlabeled antibody,b) separating the sample from the unlabeled antibody,c) incubating the unlabeled antibody with a labeled substance (tracer) for cross-reaction with the antibody andd) measuring the amount of the tracer which is or is not bound to the antibody and calculating from this the concentration of the free fraction of the active compound,wherein the quantity of the unlabeled antibody and/or its affinity for the active compound are so small that they do not substantially effect the equilibrium between the free and bound fractions of the active compound, and the affinity of the tracer for the antibody is substantially higher or substantially lower than that of the active compound itself, and a test kit suitable for this methoType: GrantFiled: June 14, 1993Date of Patent: August 15, 2000Assignee: Dade Behring Marburg GmbHInventors: Guido Simons, Helmut Strecker, deceased, Peter Molz, Gerd Schnorr, Heinz Jurgen Skrzipczyk, Hans Wissmann
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Patent number: 5714336Abstract: A method for determining the concentration of the free fraction of an active compound, present in a biological fluid, in the presence of natural binders, the free and bound fractions of the active compound being in mutual equilibrium, bya) contacting a sample of the fluid with an unlabeled antibody,b) separating the sample from the unlabeled antibody,c) incubating the unlabeled antibody with a labeled substance (tracer) for cross-reaction with the antibody andd) measuring the amount of the tracer which is or is not bound to the antibody and calculating from this the concentration of the free fraction of the active compound,wherein the quantity of the unlabeled antibody and/or its affinity for the active compound are so small that they do not substantially effect the equilibrium between the free and bound fractions of the active compound, and the affinity of the tracer for the antibody is substantially higher or substantially lower than that of the active compound itself, and a test kit suitable for this methoType: GrantFiled: May 18, 1992Date of Patent: February 3, 1998Assignee: Hoechst AktiengesellschaftInventors: Guido Simons, Helmut Strecker, deceased, Peter Molz, Gerd Schnorr, Heinz Jurgen Skrzipczyk, Hans Wissmann
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Patent number: 5068351Abstract: The invention relates to a process for the preparation of compounds of the formula I ##STR1## in which n is 1 or 2, R denotes hydrogen or an organic radical, R.sup.1 denotes an organic radical, R.sup.2 and R.sup.3 are identical or different and denote hydrogen or an organic radical, and R.sup.4 and R.sup.5, together with the atoms bearing them, form a monocyclic, bicyclic or tricyclic heterocyclic ring system having 5 to 15 carbon atoms, which process comprises reacting compounds of the formula II defined in the description with compounds of the formula IV defined in the description, in the presence of phosphinic anhydrides of the formula III, where appropriate eliminating radicals which have been introduced to protect other functional groups and, where appropriate, esterifying free carboxyl groups in a manner known per se.Type: GrantFiled: July 27, 1990Date of Patent: November 26, 1991Assignee: Hoechst AktiengesellschaftInventors: Volker Teetz, Hans Wissmann, Hansjorg Urbach
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Patent number: 5055591Abstract: The invention relates to a process for the preparation of compounds of the formula I ##STR1## in which n is 1 or 2, R denotes hydrogen or an organic radical, R.sup.1 denotes an organic radical, R.sup.2 and R.sup.3 are identical or different and denote hydrogen or an organic radical, and R.sup.4 and R.sup.5, together with the atoms bearing them, form a monocyclic, bicyclic or tricyclic heterocyclic ring system having 3 to 15 carbon atoms, which process comprises reacting compounds of the formula II defined in the description with compounds of the formula III defined in the description, in the presence of alkanephosphonic anhydrides, where appropriate eliminating radicals which have been introduced to protect other functional groups and, where appropriate, esterifying free carboxyl groups in a manner known per se.Type: GrantFiled: March 23, 1988Date of Patent: October 8, 1991Assignee: Hoechst AktiengesellschaftInventors: Hansjorg Urbach, Rainer Henning, Hans Wissmann, Volker Teetz
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Patent number: 4820860Abstract: The invention relates to novel thyronine derivatives of the formula ##STR1## in which n is 10-400, R denotes H, alkyl or N-carbonylthyronine, R.sup.1 and R.sup.2 are identical or different and denote hydrogen or iodine, and R.sup.3 denotes H or alkyl, a process for the preparation of the compounds, and their use when carrying out immunoassays.Type: GrantFiled: August 21, 1987Date of Patent: April 11, 1989Assignee: Hoechst AktiengesellschaftInventors: Hans Wissmann, Guido Simons, Helmut Strecker, deceased
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Patent number: 4814484Abstract: The invention relates to new thyronine derivatives of the formula ##STR1## in which n is 1-6, R denotes hydroxyl, alkyl or aryl, R.sup.1 and R.sup.2 are identical or different and denote iodine or hydrogen, and R.sup.3 denotes hydrogen, alkyl or aralkyl, a process for the preparation thereof, and the use thereof for carrying out radioimmunoassays.Type: GrantFiled: January 7, 1987Date of Patent: March 21, 1989Assignee: Hoechst AktiengesellschaftInventors: Hans Wissmann, Henning Hachmann, Guido Simons, Helmut Strecker
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Patent number: 4595675Abstract: What are disclosed are indole, quinoline and isoquinoline compounds of the formula ##STR1## in which n denotes 0 or 1, m denotes 1 or 2, but (n+m).ltoreq.2, A together with the bridgehead carbon atoms denotes a benzene or a cyclohexane ring, Y.sub.1 denotes hydrogen, lower alkanoyl or lower cycloalkanoyl, benzoyl nicotinoyl or a radical of the formula II, and Y.sub.2 denotes methyl, amino, lower alkanoylamino, lower cycloalkanoylamino, benzoylamino or nicotinoylamino, and salts thereof, useful as hypotensive agents, and methods for making the same.Type: GrantFiled: January 2, 1985Date of Patent: June 17, 1986Assignee: Hoechst AktiengesellschaftInventors: Rolf Geiger, Volker Teetz, Bernward Scholkens, Hans Wissmann
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Patent number: 4562202Abstract: The invention relates to compounds of the formula I ##STR1## in which n denotes 0 or 1,R denotes hydrogen, alkyl or aralkyl, R.sup.1 denotes hydrogen or alkyl, which can optionally be substituted by amino, acylamino or benzoylamino, alkenyl, cycloalkyl, cycloalkenyl, cycloalkylalkyl, aryl or partially hydrogenated aryl, which each can be substituted by alkyl, alkoxy or halogen, arylalkyl or aroylalkyl, both of which can be substituted in the aryl radical as defined in the aforegoing, a monocyclic or bicyclic sulfur or oxygen and/or nitrogen heterocyclic radical, or a side chain of a naturally occurring aminoacid, R.sup.Type: GrantFiled: March 21, 1983Date of Patent: December 31, 1985Assignee: Hoechst AktiengesellschaftInventors: Hansjorg Urbach, Rainer Henning, Volker Teetz, Hans Wissmann, Reinhard Becker
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Patent number: 4426325Abstract: To prepare compounds containing carboxylic acid amide groups, in particular peptides, there are reacted compounds containing a carboxy group, in the presence of dialkylphosphinic acid anhydrides with compounds containing a free amino group.Type: GrantFiled: January 15, 1982Date of Patent: January 17, 1984Assignee: Hoechst AktiengesellschaftInventors: Hans Wissmann, Hans-Jerg Kleiner
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Patent number: 4331592Abstract: What is disclosed is a method of making a carboxylic acid amide, including a peptide, by reacting a compound having a free amino group with a compound having a free carboxy group in the presence of an anhydride of an alkane-phosphonic acid.Type: GrantFiled: January 16, 1980Date of Patent: May 25, 1982Assignee: Hoechst AktiengesellschaftInventors: Hans Wissmann, Hans-Jerg Kleiner
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Patent number: 4053588Abstract: Pharmaceutical preparations containing an L-pyroglutamic acid amide, processes for their preparation and methods of treating psychotic diseases with them.Type: GrantFiled: May 12, 1975Date of Patent: October 11, 1977Assignee: Hoechst AktiengesellschaftInventors: Wolfgang Konig, Rolf Geiger, Hans Wissmann, Hansjorg Kruse, Michel Peterfalvi
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Patent number: 4013791Abstract: Novel peptide derivatives and a method of preparing the same are described. These compounds are useful in the diagnosis and treatment of hypertension.Type: GrantFiled: December 3, 1975Date of Patent: March 22, 1977Assignee: Hoechst AktiengesellschaftInventors: Hans Wissmann, Rolf Geiger, Ernst Lindner, Bernward Scholkens
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Patent number: 3931141Abstract: Heptapeptides of the general formulaHOOC--(CH.sub.2).sub.3 --CO--Ala--Tyr--Gly--Trp--X--Asp--Phe--NH.sub.2in which X represents leucine or methionine, and process for preparing them by reacting tert.butyl-protected heptapeptides with glutaric acid anhydride and subsequently splitting off the protective groups with the aid of trifluoroacetic acid.Type: GrantFiled: November 15, 1973Date of Patent: January 6, 1976Assignee: Hoechst AktiengesellschaftInventors: Hans Wissmann, Rolf Geiger, Rudolf Schleyerbach
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Patent number: 3931139Abstract: The invention relates to tripeptide amides containing pyroglutamine, proline and histidine as amino acids having anti-depressive activity and a process for their manufacture.Type: GrantFiled: August 22, 1974Date of Patent: January 6, 1976Assignee: Hoechst AktiengesellschaftInventors: Hans Wissmann, Rolf Geiger, Wolfgang Konig, Hansjorg Kruse, Karl Seeger