Patents by Inventor Hans-Wolfram Flemming

Hans-Wolfram Flemming has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for the production of ramipril
    Patent number: 8119375
    Abstract: An improved method for preparing ramipril is disclosed, and also an intermediate for use in the method.
    Type: Grant
    Filed: June 19, 2008
    Date of Patent: February 21, 2012
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Holger Berk, Frank Zocher, Hans-Wolfram Flemming, Rainer Gauler, Rudolf Lehnert, Wolfgang Laux
  • METHOD FOR THE PRODUCTION OF RAMIPRIL
    Publication number: 20090017509
    Abstract: An improved method for preparing ramipril is disclosed, and also an intermediate for use in the method.
    Type: Application
    Filed: June 19, 2008
    Publication date: January 15, 2009
    Applicant: sanofi-aventis Deutschland GmbH
    Inventors: Holger BERK, Frank ZOCHER, Hans-Wolfram FLEMMING, Rainer GAULER, Rudolf LEHNERT, Wolfgang LAUX
  • NOVEL PROCESSES FOR THE PREPARATION OF (R)-ALPHA-(2,3-DIMETHOXYPHENYL)-1-[2-(4-FLUOROPHENYL)ETHYL]-4-PIPERIDINEMETHANOL
    Publication number: 20070265450
    Abstract: The present invention provides various processes for the preparation of (R)-?-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol.
    Type: Application
    Filed: July 25, 2007
    Publication date: November 15, 2007
    Applicants: AVENTIS PHARMACEUTICALS INC., SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Thomas Hilpert, Hans-Wolfram Flemming, Sandra Stolz-Dunn, Jonathan Evans, Ian Tomlinson
  • Process for preparing pyridine-substituted amino ketal derivatives
    Patent number: 6916934
    Abstract: The present invention relates to an efficient process for preparing derivatives of 1-(pyridinyl)-1,1-dialkoxy-2-aminoethane of the formula (I), with which compounds of the formula (I) can be prepared in high purity and yield and in the form of the free base without isolating the acetylpyridine oxime of the formula (XI) which is a critical product from a safety point of view as a solid.
    Type: Grant
    Filed: January 26, 2004
    Date of Patent: July 12, 2005
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Hans-Wolfram Flemming, Gerhard Korb, Juergen Mueller-Lehar, Walter Weber
  • Novel processes for the preparation of (R)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl) ethyl]-4-piperidinemethanol
    Publication number: 20040210061
    Abstract: The present invention provides various processes for the preparation of (R)-&agr;-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol.
    Type: Application
    Filed: May 4, 2004
    Publication date: October 21, 2004
    Applicants: Aventis Pharmaceuticals Inc., Aventis Pharma Deutschland GmbH
    Inventors: Thomas Heinz Eduard Hilpert, Hans-Wolfram Flemming, Sandra K. Stolz-Dunn, Jonathan C. Evans, Ian A. Tomlinson
  • Process for preparing pyridine-substituted amino ketal derivatives
    Publication number: 20040158073
    Abstract: The present invention relates to an efficient process for preparing derivatives of 1-(pyridinyl)-1,1-dialkoxy-2-aminoethane of the formula (I), with which compounds of the formula (I) can be prepared in high purity and yield and in the form of the free base without isolating the acetylpyridine oxime of the formula (XI) which is a critical product from a safety point of view as a solid.
    Type: Application
    Filed: January 26, 2004
    Publication date: August 12, 2004
    Applicant: Aventis Pharma Deutschland GmbH
    Inventors: Hans-Wolfram Flemming, Gerhard Korb, Juergen Mueller-Lehar, Walter Weber
  • Processes for the preparation of (R)-&agr;-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol
    Patent number: 6713627
    Abstract: The present invention provides various processes for the preparation of (R)-&agr;-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol.
    Type: Grant
    Filed: January 11, 2002
    Date of Patent: March 30, 2004
    Assignee: Aventis Pharmaceuticals Inc.
    Inventors: Edward D. Daugs, Jonathan C. Evans, Hans-Wolfram Flemming, Thomas Heinz Eduard Hilpert, Johannes Nicolaas Koek, Frederick M. Laskovics, Sandra K. Stolz-Dunn, Ian A. Tomlinson
  • Novel processes for the preparation or (R)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol
    Publication number: 20020151717
    Abstract: The present invention provides various processes for the preparation of (R)-&agr;-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol.
    Type: Application
    Filed: January 11, 2002
    Publication date: October 17, 2002
    Inventors: Edward D. Daugs, Jonathan C. Evans, Hans-Wolfram Flemming, Thomas Heinz Eduard Hilpert, Johannes Nicolaas Koek, Frederick M. Laskovics, Sandra K. Stolz-Dunn, Ian A. Tomlinson
  • Process for the preparation of &agr;,&agr;- dimethylphenylacetic acid from &agr;,&agr;-dimethylbenzyl cyanide under normal pressure
    Patent number: 6281383
    Abstract: A process for obtaining &agr;,&agr;-dimethylphenylacetic acid wherein &agr;,&agr;dimethylbenzyl cyanide is reacted in the presence of sodium hydroxide, water and a C4- and/or C5-alcohol at temperatures above about 100° C. and the &agr;,&agr;-dimethylphenylacetic acid is obtained by acidification.
    Type: Grant
    Filed: September 24, 1999
    Date of Patent: August 28, 2001
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Gerhard Korb, Hans-Wolfram Flemming, Rudolf Lehnert, Wolfgang Rybczynski
  • Process for the alkylation of alkyl-or benzylcyanogen derivatives in the presence of trialkylamines or trialkylphosphines
    Patent number: 6143896
    Abstract: A process for the alkylation of compounds of the formula II ##STR1## where the reaction with the alkylating agent is carried out in the presence of a base and a trialkylamine and/or trialkylphosphine.
    Type: Grant
    Filed: December 16, 1998
    Date of Patent: November 7, 2000
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Gerhard Korb, Hans-Wolfram Flemming, Rudolf Lehnert
  • Process for obtaining 3,7-dialkylxanthines from 3-alkyl-xanthines
    Patent number: 5475107
    Abstract: Process for obtaining 3,7-dialkylxanthines from 3-alkyl-xanthines3,7-Dialkylxanthines are obtained from the corresponding 3-alkylxanthines using an alkylating agent in the presence of quaternary ammonium and/or phosphonium compounds and, where appropriate, of additional polyethers in a two-phase mixture.
    Type: Grant
    Filed: November 9, 1993
    Date of Patent: December 12, 1995
    Assignee: Hoechst-Roussel Pharmaceuticals Incorporated
    Inventors: Gerhard Korb, Hans-Wolfram Flemming
  • Process for the preparation of tripeptides
    Patent number: 5191065
    Abstract: A process for the preparation of tripeptides of the general formula IU-A-B-C-OH Iin which U denotes hydrogen or a urethane protective group and A, B and C denote amino acids, by reaction of a compound of the general formula IIU'-B-OH IIin which U' is a urethane protective group which can be eliminated by hydrogenolysis, with a compound of the general formula IIIH-C-OR IIIin which R denotes alkyl, by the PPA method, elimination of U', and reacting the resulting compound of the formula IVH-B-C-OR IVwith a compound of the formula VU-A-OH Vin the presence of propylphosphonic anhydride, and finally eliminating R enzymatically.
    Type: Grant
    Filed: July 8, 1991
    Date of Patent: March 2, 1993
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Hans-Wolfram Flemming, Manfred Rukwied, Manfred Schmidt
  • Process for the preparation of thiophene derivatives and also new dihydrothiophene 1-oxides
    Patent number: 5166346
    Abstract: Process for the preparation of thiophene derivatives and also new dihydrothiophene 1-oxides.Thiophene derivatives having an--optionally substituted--amino group on the thiophene ring are prepared by dehydrogenating dihydrothiophenes, substituted in a manner identical to that of the desired thiophene derivatives, by means of H.sub.2 O.sub.2, the dihydrothiophenes being reacted with H.sub.2 O.sub.2 in a first reaction stage in a neutral medium to give the corresponding sulfoxides, which are then rearranged into the thiophene derivatives by means of acid in the second reaction stage.The dihydrothiophene 1-oxides formed as intermediates in this reaction are new compounds. Like the thiophene derivatives formed from them by rearrangement with acid, they are intermediates, mainly in the sector of plant protection agents and pharmaceuticals.
    Type: Grant
    Filed: December 20, 1990
    Date of Patent: November 24, 1992
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Robert Rippel, Hans-Wolfram Flemming, Manfred Rukwied