Patents by Inventor Hans Wolfram

Hans Wolfram has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20180346494
    Abstract: A novel compound chlorosilylarylgermane, a method for preparing the compound, and the use of the compound are described. A method for preparing trichlorosilyltrichlorogermane and the use of trichlorosilyltrichlorogermane are also described.
    Type: Application
    Filed: May 31, 2018
    Publication date: December 6, 2018
    Applicant: Evonik Degussa GmbH
    Inventors: Julian Teichmann, Matthias Wagner, Hans-Wolfram Lerner
  • Publication number: 20180346495
    Abstract: A trichlorogermanide of formula (I): [R4N]/[R4P]Cl[GeCl3] (I), where R is Me, Et, iPr, nBu, or Ph, tris(trichlorosilyl)germanide of formula (II): [R4N]/[R4P][Ge(SiCl3)3] (II), where R is Me, Et, iPr, nBu, or Ph, a tris(trichlorosilyl)germanide adduct of GaCl3 of formula (III): [Ph4P][Ge(SiCl3)3*GaCl3], and a tris(trichlorosilyl)germanide adduct of BBr3 of formula (IV): [Ph4P][Ge(SiCl3)3*BBr3]. Also, methods for preparing the trichlorogermanides of formula (I), the tris(trichlorosilyl)germanide of formula (II), the tris(trichlorosilyl)germanide adduct of BBr3 of formula (IV).
    Type: Application
    Filed: May 31, 2018
    Publication date: December 6, 2018
    Applicant: Evonik Degussa GmbH
    Inventors: Julian Teichmann, Matthias Wagner, Hans-Wolfram Lerner
  • Publication number: 20170349444
    Abstract: The present invention relates to a process for the production of perhalogenated hexasilane anion by reacting halogenated monosilane in the presence of organosubstituted ammonium and/or phosphonium halide at temperatures in a range from 100 to 120° C., wherein no solvent is used, and a process for the production of a cyclic silane compound of the formula Si6R12, by reacting [X]2[Si6Cl14] with AlR3 in at least one organic solvent, wherein R is chlorine or methyl and X, the same or different, is a counter-cation and is preferably selected from organosubstituted ammonium, organosubstituted phosphonium, alkali metal ions and [(PEDETA)(H2SiCl)]+.
    Type: Application
    Filed: December 8, 2015
    Publication date: December 7, 2017
    Inventors: Matthias WAGNER, Hans-Wolfram LERNER, Jan TILLMANN, Maximilian MOXTER
  • Publication number: 20160311691
    Abstract: The present invention relates to a process for the preparation of linear, cyclic and/or cage-type perhalogenated oligosilyl and polysilyl anions by reacting perhalogenated monosilanes, oligosilanes or polysilanes with organosubstituted ammonium and/or phosphonium halides at temperatures ranging from ?80° C. to 85° C., preferably ?80° C. to 60° C., and to oligosilyl and polysilyl anions prepared according to that process.
    Type: Application
    Filed: December 12, 2014
    Publication date: October 27, 2016
    Inventors: Matthias WAGNER, Jan TILLMANN, Norbert AUNER, Lioba MEYER, Max HOLTHAUSEN, Hans-Wolfram LERNER
  • Patent number: 8119375
    Abstract: An improved method for preparing ramipril is disclosed, and also an intermediate for use in the method.
    Type: Grant
    Filed: June 19, 2008
    Date of Patent: February 21, 2012
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Holger Berk, Frank Zocher, Hans-Wolfram Flemming, Rainer Gauler, Rudolf Lehnert, Wolfgang Laux
  • Publication number: 20090017509
    Abstract: An improved method for preparing ramipril is disclosed, and also an intermediate for use in the method.
    Type: Application
    Filed: June 19, 2008
    Publication date: January 15, 2009
    Applicant: sanofi-aventis Deutschland GmbH
    Inventors: Holger BERK, Frank ZOCHER, Hans-Wolfram FLEMMING, Rainer GAULER, Rudolf LEHNERT, Wolfgang LAUX
  • Publication number: 20070265450
    Abstract: The present invention provides various processes for the preparation of (R)-?-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol.
    Type: Application
    Filed: July 25, 2007
    Publication date: November 15, 2007
    Applicants: AVENTIS PHARMACEUTICALS INC., SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Thomas Hilpert, Hans-Wolfram Flemming, Sandra Stolz-Dunn, Jonathan Evans, Ian Tomlinson
  • Patent number: 6916934
    Abstract: The present invention relates to an efficient process for preparing derivatives of 1-(pyridinyl)-1,1-dialkoxy-2-aminoethane of the formula (I), with which compounds of the formula (I) can be prepared in high purity and yield and in the form of the free base without isolating the acetylpyridine oxime of the formula (XI) which is a critical product from a safety point of view as a solid.
    Type: Grant
    Filed: January 26, 2004
    Date of Patent: July 12, 2005
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Hans-Wolfram Flemming, Gerhard Korb, Juergen Mueller-Lehar, Walter Weber
  • Publication number: 20040210061
    Abstract: The present invention provides various processes for the preparation of (R)-&agr;-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol.
    Type: Application
    Filed: May 4, 2004
    Publication date: October 21, 2004
    Applicants: Aventis Pharmaceuticals Inc., Aventis Pharma Deutschland GmbH
    Inventors: Thomas Heinz Eduard Hilpert, Hans-Wolfram Flemming, Sandra K. Stolz-Dunn, Jonathan C. Evans, Ian A. Tomlinson
  • Publication number: 20040158073
    Abstract: The present invention relates to an efficient process for preparing derivatives of 1-(pyridinyl)-1,1-dialkoxy-2-aminoethane of the formula (I), with which compounds of the formula (I) can be prepared in high purity and yield and in the form of the free base without isolating the acetylpyridine oxime of the formula (XI) which is a critical product from a safety point of view as a solid.
    Type: Application
    Filed: January 26, 2004
    Publication date: August 12, 2004
    Applicant: Aventis Pharma Deutschland GmbH
    Inventors: Hans-Wolfram Flemming, Gerhard Korb, Juergen Mueller-Lehar, Walter Weber
  • Patent number: 6713627
    Abstract: The present invention provides various processes for the preparation of (R)-&agr;-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol.
    Type: Grant
    Filed: January 11, 2002
    Date of Patent: March 30, 2004
    Assignee: Aventis Pharmaceuticals Inc.
    Inventors: Edward D. Daugs, Jonathan C. Evans, Hans-Wolfram Flemming, Thomas Heinz Eduard Hilpert, Johannes Nicolaas Koek, Frederick M. Laskovics, Sandra K. Stolz-Dunn, Ian A. Tomlinson
  • Publication number: 20020151717
    Abstract: The present invention provides various processes for the preparation of (R)-&agr;-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol.
    Type: Application
    Filed: January 11, 2002
    Publication date: October 17, 2002
    Inventors: Edward D. Daugs, Jonathan C. Evans, Hans-Wolfram Flemming, Thomas Heinz Eduard Hilpert, Johannes Nicolaas Koek, Frederick M. Laskovics, Sandra K. Stolz-Dunn, Ian A. Tomlinson
  • Patent number: 6281383
    Abstract: A process for obtaining &agr;,&agr;-dimethylphenylacetic acid wherein &agr;,&agr;dimethylbenzyl cyanide is reacted in the presence of sodium hydroxide, water and a C4- and/or C5-alcohol at temperatures above about 100° C. and the &agr;,&agr;-dimethylphenylacetic acid is obtained by acidification.
    Type: Grant
    Filed: September 24, 1999
    Date of Patent: August 28, 2001
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Gerhard Korb, Hans-Wolfram Flemming, Rudolf Lehnert, Wolfgang Rybczynski
  • Patent number: 6143896
    Abstract: A process for the alkylation of compounds of the formula II ##STR1## where the reaction with the alkylating agent is carried out in the presence of a base and a trialkylamine and/or trialkylphosphine.
    Type: Grant
    Filed: December 16, 1998
    Date of Patent: November 7, 2000
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Gerhard Korb, Hans-Wolfram Flemming, Rudolf Lehnert
  • Patent number: 5763397
    Abstract: Desmethylbalhimycin, a compound of the formula C.sub.65 H.sub.71 Cl.sub.2 N.sub.9 O.sub.24, desmethylleucylbalhimycin, a compound of the formula C.sub.59 H.sub.60 Cl.sub.2 N.sub.8 O.sub.23, desglucobalhimycin, a compound of the formula C.sub.60 H.sub.63 Cl.sub.2 N.sub.9 O.sub.19, ureidobalhimycin, a compound of the formula C.sub.67 H.sub.74 Cl.sub.2 N.sub.10 O.sub.25, desmethyl-desglucobalhimycin, a compound of the formula C.sub.59 H.sub.61 Cl.sub.2 N.sub.9 O.sub.19 and balhimycin V, a compound of the formula C.sub.73 H.sub.84 Cl.sub.2 N.sub.10 I.sub.26, methylbalhimycin, a compound of the formula C.sub.67 H.sub.75 Cl.sub.2 N.sub.9 O.sub.24 and balhimycin R, a compound of the formula C.sub.72 H.sub.83 Cl.sub.2 N.sub.9 O.sub.28, have an antibiotic action.
    Type: Grant
    Filed: June 29, 1992
    Date of Patent: June 9, 1998
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Laszlo Vertesy, Joachim Betz, Hans-Wolfram Fehlhaber, Michael Limbert
  • Patent number: 5721208
    Abstract: Novel glycopeptides, a process for their preparation and their useDesmethylbalhimycin, a compound of the formula C.sub.65 H.sub.71 Cl.sub.2 N.sub.9 O.sub.24, desmethylleucylbalhimycin, a compound of the formula C.sub.59 H.sub.60 Cl.sub.2 N.sub.8 O.sub.23, desglucobalhimycin, a compound of the formula C.sub.60 H.sub.63 Cl.sub.2 N.sub.9 O.sub.19, ureidobalhimycin, a compound of the formula C.sub.67 H.sub.74 Cl.sub.2 N.sub.10 O.sub.25, desmethyl-desglucobalhimycin, a compound of the formula C.sub.59 H.sub.61 Cl.sub.2 N.sub.9 O.sub.19 and balhimycin V, a compound of the formula C.sub.73 H.sub.84 Cl.sub.2 N.sub.10 I.sub.26, methylbalhimycin, a compound of the formula C.sub.67 H.sub.75 Cl.sub.2 N.sub.9 O.sub.24 and balhimycin R, a compound of the formula C.sub.72 H.sub.83 Cl.sub.2 N.sub.9 O.sub.28, have an antibiotic action.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: February 24, 1998
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Laszlo Vertesy, Joachim Betz, Hans-Wolfram Fehlhaber, Michael Limbert
  • Patent number: 5648333
    Abstract: Peptides of the formula IA-B-C-E-F-K-P-G-M-F'-I (I),wherein the terms A, B, C, E, F, K, P, G, M, F', and I are defined in the specification, have bradykinin antagonist action. Their therapeutic utility includes all pathological states which are mediated, caused or supported by bradykinin and bradykinin-related peptides.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: July 15, 1997
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Stephan Henke, Hiristo Anagnostopulos, Gerhard Breipohl, Jochen Knolle, Jens Stechl, Bernward Scholkens, Hans-Wolfram Fehlhaber, Hermann Gerhards, Franz Hock
  • Patent number: 5571701
    Abstract: Balhimycin, a compound of the molecular formula C.sub.66 H.sub.73 C1.sub.2 N.sub.9 0.sub.
    Type: Grant
    Filed: May 24, 1995
    Date of Patent: November 5, 1996
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Suresh R. Nadkarni, Sugata Chatterjee, Mahesh V. Patel, Kalvanapuram R. Desikan, Erra K. S. Vijayakumar, Bimal N. Ganguli, Jurgen Blumbach, Hans-Wolfram Fehlhaber, Herbert Kogler
  • Patent number: 5519123
    Abstract: The novel substances nordanoxamine and desferrinordanoxamine, and desferrisalmycin A, B, C and D, as well as the known substances danoxamine and desferridanoxamine, are prepared from the antibiotics salmycin A, B, C and D, which are obtained by fermentation. These substances are used as chelating agents and pharmaceuticals.
    Type: Grant
    Filed: August 5, 1994
    Date of Patent: May 21, 1996
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Laszlo Vertesy, Werner Aretz, Hans-Wolfram Fehlhaber
  • Patent number: 5475107
    Abstract: Process for obtaining 3,7-dialkylxanthines from 3-alkyl-xanthines3,7-Dialkylxanthines are obtained from the corresponding 3-alkylxanthines using an alkylating agent in the presence of quaternary ammonium and/or phosphonium compounds and, where appropriate, of additional polyethers in a two-phase mixture.
    Type: Grant
    Filed: November 9, 1993
    Date of Patent: December 12, 1995
    Assignee: Hoechst-Roussel Pharmaceuticals Incorporated
    Inventors: Gerhard Korb, Hans-Wolfram Flemming