Abstract: A microbiological process for the preparation of N,N'-ethylenediaminedisuccinic acid of formula (1), by (a) precultivation of a strain of the genus Amycolatopsis orientalis on a specified nutrient medium (1st preculture), (b) inoculation of a nutrient solution of the same composition as the base of the production fermenter by the 1st preculture (2nd preculture), (c) inoculation of the base nutrient solution in the production fermenter with the 2nd preculture and incubation in accordance with a specified timetable, (d) feeding of the production fermenter in the fed-batch process with a feeding solution under aerobic conditions at a pH of from 2 to 8 and at a temperature of from 15.degree. to 40.degree. C., wherein the base nutrient and feeding solutions are free of zinc-containing compounds, is described. The compound prepared by the process according to the invention is suitable as complexing agent with good biodegradability in detergents.

Abstract: A new polycyclic peptide antibiotic termed gallidermin is disclosed and described, together with a process for producing such antibiotic by fermination of a new microorganism, Staphylococcus gallinarum (DSM 4616).

Abstract: R.sup.2 is H or OH;R.sup.3 is H, OH, OCH.sub.3, CH.sub.3 or NH.sub.2 ;Rhu 4 is H, OH, OCH.sub.3, NH.sub.2 or ##STR2## The compounds of the formula I are prepared by fermentation of the strain Streptomyces parvulus DSM 40722 in the presence of substituted benzoic acids of the general formula II ##STR3## where R.sup.1 is H or OH;R.sup.2 is H or OH;R.sup.3 is H, OH, OCH.sub.3, CH.sub.3 or NH.sub.2 ;R.sup.4 is H, OH, OCH.sub.3 or NH.sub.2,and they inhibit Leukocyte elastase and can be used as pharmaceuticals.

Abstract: The O-acyl derivatives of urdamycin A exhibit an antibiotic or antitumoral activity.

Abstract: A new substance, urdamycin G, has been found which, like its O-acyl derivatives, exhibits an antibiotic or antitumoral activity.

Abstract: A method of combating arthropods, comprising applying to the arthropods, or to a habitat infested therewith an arthropodicidally effective amount of an antibiotic which (a) is colorless, very readily soluble in water and in pyridine but insoluble in other customary organic solvents, gives a positive reaction with ninhydrin, sodium metaperiodate/benzidine and potassium permanganate and gives a yellow coloration with iron (III) chloride, (b) has the UV and IR spectra substantially as shown in FIGS. 1 and 2, (c) on chemical degradation yields uracil, an amino-hexuronic acid and an amino-acid containing a pyridine ring, (d) on paper electrophoresis proves to be an amphoteric substance and has an isoelectric point at about pH 6 and (e) consists of the elements carbon, hydrogen, oxygen and nitrogen, or one or more active components of the antibiotic mixture, the active agent being applied alone or in admixture with a diluent or carrier.

Abstract: Bafilomycins of the formula ##STR1## in which R.sup.1 is hydrogen or CH.sub.3, andR.sup.2 is hydrogen, or the group ##STR2## are produced by culturing certain streptomyces, e.g. Tu 1922, Tu 2437 and Tu 2599. Those wherein at least one of the OH groups is acylated are new. The compounds are pesticidally active.

Abstract: The invention relates especially to 2-(3'-hydroxypyrid-2'-yl)-2-thiazoline-4-carboxylic acid derivatives of the formula (I) and salts and also certain metal complexes of these compounds, processes for their manufacture, pharmaceutical agents containing such compounds and the use of these compounds. ##STR1## In the formula, R.sup.1 represents free, etherified or esterified hydroxy, R.sup.2 represents hydrogen or an aliphatic, carbocyclic or carbocyclic-aliphatic radical having 1-12 carbon atoms, and R.sup.3 represents hydrogen or an unsubstituted aliphatic radical having 1-7 carbon atoms.The compounds of the formula (I) can be used, for example, for the abstraction of heavy metals from the organism of warm-blooded animals and/or they have an antibiotic action.

Abstract: Pesticidally active substantially pure nikkomicin fractions obtained from Streptomyces tendae Ettlinger et al Tu 901, the fractions being selected from the group consisting of ##STR1## a mixture of nikkomicin I and J, and a mixture of nikkomicin M and N.

Abstract: A method of combating arthropods, comprising applying to the arthropods, or to a habitat infested therewith an arthropodicidally effective amount of an antibiotic which (a) is colorless, very readily soluble in water and in pyridine but insoluble in other customary organic solvents, gives a positive reaction with ninhydrin, sodium metaperiodate/benzidine and potassium permanganate and gives a yellow coloration with iron (III) chloride, (b) has the UV and IR spectra substantially as shown in FIGS. 1 and 2, (c) on chemical degradation yields uracil, an amino-hexuronic acid and an amino-acid containing a pyridine ring, (d) on paper electrophoresis proves to be an amphoteric substance and has an isolectric point at about pH 6 and (e) consists of the elements carbon, hydrogen, oxygen and nitrogen, or one or more active components of the antibiotic mixture, the active agent being applied alone or in admixture with a diluent or carrier.

Abstract: The invention relates to the new antibiotic Lysolipin including two components X and I, and derivatives thereof. Lysolipin is formed when the strain Streptomyces violaceoniger (Waksman et Curtis) Waksman et Henrici Tu 96, which strain has been deposited under the reference NRRL 8097 at the Northern Regional Laboratory, U.S. Department of Agriculture, Peoria, Illinois, is cultured in a nutrient medium. The structural formulae of the 2 components are ##STR1## Lysolipin I and X and their derivatives have antibacterial activity and are effective against yeast - like fungi, such as Candida albicans. Their antibiotic action probably depends on an inhibition of the cell wall synthesis.

Abstract: The invention provides compositions containing cladosporin and/or analogs of cladosporin. Said composition in the form of treated feed compositions or treated drinking water promote and accelerate the growth of animals and improve feedstuff utilization.

Abstract: The new antibiotic Nikkomycin is produced by culturing the strain Streptomyces tendae Ettlinger et al Tu 901 in a nutrient medium at a pH of about 5.5 to 8 under aerobic conditions and isolation by cation exchange from the culture filtrate, followed by elution. The antibiotic is believed to have the structural formula ##STR1## and is characterized by fungicidal activity.

Abstract: The new antibiotic Nikkomycin is produced by culturing the strain Streptomyces tendae Ettlinger et al Tu 901 in a nutrient medium at a pH of about 5.5 to 8 under aerobic conditions and isolation by cation exchange from the culture filtrate, followed by elution. The antibiotic is believed to have the structural formula ##STR1## and is characterized by fungicidal activity.